Date published: 2025-9-7

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IKKβ 抗体 (24): sc-135948

4.0(2)
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说明书
  • IKK beta 抗体 24 是小鼠单克隆 IgG1, 在1篇文献中引用,提供 50 µg/500 µl
  • 免疫human物种的IKKβ的氨基酸629-735
  • 推荐用于 human 和 canine 来源的IKKβ WB, IP 和 IF检测
  • 看 IKKβ (H-4): sc-8014,可查看有标记的 IKKβ 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成IKKβ 抗体 (24)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

转录因子NFkB被抑制蛋白IkB以非活性形式保留在细胞质中。NFkB的激活需要IkB在特定的丝氨酸残基上被磷酸化,这会导致IkB的靶向降解 。IkB激酶α(IKKα),以前称为CHUK,与IkB-α相互作用并特异性地在丝氨酸32和36上磷酸化IκBα,这两个位点是触发其降解的位点。IKKα似乎是响应促炎细胞因子激活NFkB的关键。IKKα对IkB的磷酸化受NFkB诱导激酶(NIK)的刺激,而NIK本身是响应TNF和IL-1激活NFkB的中心调节因子。功能性的IKK复合物包含三个亚基,IKKα、IKKβ和IKKγ(也称为NEMO),每个亚基似乎都对IkB的磷酸化做出了重要贡献。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IKKβ 抗体 (24) 参考文献:

  1. 酪氨酸磷酸化可使 IKKβ 整合多种信号输入。  |  Meyer, AN., et al. 2013. PLoS One. 8: e84497. PMID: 24386391
  2. 活性 IKKβ 能促进弥漫大 B 细胞淋巴瘤中 GLI1 致癌基因的稳定性。  |  Agarwal, NK., et al. 2016. Blood. 127: 605-15. PMID: 26603838
  3. 在肠道肿瘤形成过程中,IKKβ在癌相关成纤维细胞中起到肿瘤抑制剂的作用。  |  Pallangyo, CK., et al. 2015. J Exp Med. 212: 2253-66. PMID: 26621452
  4. IKKβ通过磷酸化并抑制PFKFB3来促进对谷氨酰胺缺乏的代谢适应。  |  Reid, MA., et al. 2016. Genes Dev. 30: 1837-51. PMID: 27585591
  5. NEMO-IKKβ在cGAS-STING通路中对于IRF3和NF-κB的激活至关重要。  |  Fang, R., et al. 2017. J Immunol. 199: 3222-3233. PMID: 28939760
  6. IKKβ激酶促进KRAS驱动的肺腺癌细胞的干细胞特性、迁移和侵袭。  |  Rodrigues, FS., et al. 2020. Int J Mol Sci. 21: PMID: 32823550
  7. 鼻咽癌中NF-κB p65和IKKβ蛋白和mRNA表达的临床病理学分析和预后意义。  |  Zhou, M., et al. 2022. J Int Med Res. 50: 3000605211069195. PMID: 34994235
  8. 肥胖小鼠不能耐受肝脏和白细胞中IKKβ的体细胞缺失,但肝脏IKKβ缺失可改善脂肪肝和胰岛素敏感性。  |  Silva, VRR., et al. 2022. FASEB J. 36: e22512. PMID: 36001064
  9. 通过IKKβ的持续激活导致小鼠皮肤成纤维细胞的衰老。  |  Harada, M., et al. 2024. Cell Cycle. 23: 308-327. PMID: 38461418
  10. 食管上皮Ikkβ缺失在实验性过敏小鼠模型中促进嗜酸性食管炎。  |  Clevenger, MH., et al. 2024. bioRxiv.. PMID: 39026724

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IKKβ 抗体 (24)

sc-135948
50 µg/500 µl
RMB2377.00

Hi, I want to detect the dog IKKβ. I tried many times (dilution-1:1000, 1:500, 1:200) but I don't find any signal in my western blot. Secondary antibody was peroxidase-conjugated affinipure goat Anti-mouse IgG (H+L) @ 1:10000 dilution. Any suggestion plz

Asked by: Mahfuz
Thank you for your question. Please contact our Technical Service Department or your local distributor for assistance in troubleshooting this antibody.
Answered by: Tech Service
Date published: 2023-05-31

I am using IKKβ (24): sc-135948 for immunofluorescence, what dilution of this antibody should I use?

Asked by: Germaine
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2019-03-18
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Rated 4 out of 5 by from Produced good immunofluorescence cytoplasmicProduced good immunofluorescence cytoplasmic staining in HeLa cells. -SCBT QC
Date published: 2015-04-26
Rated 4 out of 5 by from WB positive in HeLa whole cell lysateWB positive in HeLa whole cell lysate. -SCBT QC
Date published: 2015-03-07
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IKKβ 抗体 (24) is rated 4.0 out of 5 by 2.
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