Date published: 2025-9-6

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IGFBP1 抗体 (H-3): sc-25257

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说明书
  • IGFBP1抗体(H-3)是小鼠单克隆IgG2a κ, 在7篇文献中引用,规格为200 µg/ml
  • 免疫human物种的IGFBP1的氨基酸121-240
  • 推荐用于 human 来源的IGFBP1 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 IGFBP1 抗体 (H-3) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与IGFBP1 抗体 (H-3) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

胰岛素样生长因子结合蛋白(IGFBPs)是一个与IGFs共同进化的同源蛋白家族,不仅作为可溶性IGFs的转运分子,还对IGF信号系统具有一定的调节作用。IGFBP与IGF的物理结合影响生长因子的生物利用度以及它们在细胞外环境中的浓度和分布。此外,IGFBPs似乎还具有与IGFs无关的生物学活性。目前已经描述了7种IGFBP,每种在组织分布、半衰期和调节IGF与其受体相互作用方面存在差异。IGFBP1受到胰岛素生产的负调节。IGFBP1基因在胎儿肝脏发育期间以及响应营养变化和糖尿病时高表达。IGFBP2可能作为伴侣分子,将IGFs引导至靶组织,在包括胎儿眼睛和胎儿大脑在内的人体组织中表达。最丰富的IGFBP是IGFBP3,与大约80%的血清IGFs形成复合物。IGFBP3和IGFBP4均由真皮成纤维细胞在切割损伤时释放。IGFBP5由肌母细胞分泌,可能在肌肉分化中发挥关键作用。与其他IGFBP相比,IGFBP6具有最高的IGF-II亲和力。糖基化的人IGFBP6在中国仓鼠卵巢(CHO)细胞中表达,而非糖基化的人重组IGFBP-6在E.coli中表达。IGFBP7是一种分泌蛋白,与IGF-I和IGF-II的亲和力相对较低,可刺激前列腺素I2的产生,并可能发挥生长抑制因子的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IGFBP1 抗体 (H-3) 参考文献:

  1. 诊断前血浆IGFBP-1、IGF-1和前列腺癌风险。  |  Cao, Y., et al. 2015. Int J Cancer. 136: 2418-26. PMID: 25348852
  2. 代谢性疾病中IGFBP-1的调节。  |  Bae, JH., et al. 2013. J Lifestyle Med. 3: 73-9. PMID: 26064841
  3. IGFBP-1和IGFBP-2的生理学和病理生理学--代谢控制和恶性潜能的共识和分歧。  |  Hoeflich, A. and Russo, VC. 2015. Best Pract Res Clin Endocrinol Metab. 29: 685-700. PMID: 26522454
  4. IGFBP-1在癌症中的表达、分子机制和潜在临床意义。  |  Lin, YW., et al. 2021. Am J Transl Res. 13: 813-832. PMID: 33841624
  5. IGFBP1在空间受限迁移过程中维持细胞存活并促进肿瘤转移。  |  Cai, G., et al. 2023. Adv Sci (Weinh). 10: e2206540. PMID: 37296072
  6. 通过IGFBP-1基因中的SNP解决先兆子痫。  |  Bokuda, K. 2023. Hypertens Res. 46: 2430-2432. PMID: 37582849
  7. 血清IGFBP-1作为结直肠癌诊断和预后生物标志物的前景。  |  Huang, BL., et al. 2024. Sci Rep. 14: 1839. PMID: 38246959
  8. 妊娠早期胎盘IGFBP1水平与胰岛素抵抗和妊娠糖尿病的风险有关。  |  Hivert, MF., et al. 2024. Nat Med. 30: 1689-1695. PMID: 38627562
  9. 胰岛素样生长因子结合蛋白-1(IGFBP-1)作为心血管疾病的生物标志物。  |  Lewitt, MS. and Boyd, GW. 2024. Biomolecules. 14: PMID: 39595651
  10. 人类IGFBP-1的调节。  |  Brismar, K., et al. 1995. Prog Growth Factor Res. 6: 449-56. PMID: 8817689

订购信息

产品名称产品编号规格价格数量收藏夹

IGFBP1 抗体 (H-3)

sc-25257
200 µg/ml
RMB2377.00

IGFBP1 (H-3): m-IgG Fc BP-HRP 套装

sc-536695
200 µg Ab; 10 µg BP
RMB2662.00

IGFBP1 (H-3): m-IgGκ BP-HRP 套装

sc-533855
200 µg Ab; 40 µg BP
RMB2662.00

IGFBP1 (H-3): m-IgG2a BP-HRP 套装

sc-547847
200 µg Ab; 10 µg BP
RMB2662.00

I am using IGFBP1 (H-3): sc-25257 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: TinTin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human renal cancer. -SCBT QC
Date published: 2015-05-11
Rated 5 out of 5 by from Publishable immunostaining in paraffin embeddedPublishable immunostaining in paraffin embedded human ovarian epithelial carcinoma. -SCBT Publication Review
Date published: 2015-05-03
Rated 5 out of 5 by from Large signal achieved in WB with human recombinantLarge signal achieved in WB with human recombinant IGFBP1. -SCBT QC
Date published: 2015-04-01
Rated 5 out of 5 by from Nice WB band obtained against Hep G2 wholeNice WB band obtained against Hep G2 whole cell lysate. -SCBT QC
Date published: 2015-03-17
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IGFBP1 抗体 (H-3) is rated 5.0 out of 5 by 4.
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