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IGF-1 Receptor β/IGF1R Antibody (D-11) - Western Blotting - Image 353164
IGF-IRβ (D-11): sc-398250. HeLa (A), NCI-H226 (B) 和 RPMI2650 (C) 全细胞裂解液中 IGF-IRβ 表达的 Western 印迹分析.
IGF-1 Receptor β/IGF1R Antibody (D-11) - Western Blotting - Image 353164
IGF-IRβ (D-11): sc-398250. HeLa (A), NCI-H226 (B) 和 RPMI2650 (C) 全细胞裂解液中 IGF-IRβ 表达的 Western 印迹分析.
IGF-1 Receptor β/IGF1R Antibody (D-11) - Western Blotting - Image 303466
IGF-IRβ (D-11): sc-398250. HeLa (A) 和 A-431 (B) 全细胞裂解液中 IGF-IRβ 表达的 Western 印迹分析.
IGF-1 Receptor β/IGF1R Antibody (D-11) - Western Blotting - Image 360987
IGF-IRβ (D-11): sc-398250. HeLa (A), MCF7 (B) 和 KNRK (C) 全细胞裂解液及小鼠脑组织提取物 (D) 中 IGF-IRβ 表达的 Western 印迹分析.
IGF-IRβ (D-11): sc-398250. HeLa (A), NCI-H226 (B) 和 RPMI2650 (C) 全细胞裂解液中 IGF-IRβ 表达的 Western 印迹分析.

IGF-1 Receptor β/IGF1R 抗体 (D-11): sc-398250

5.0(2)
寫評論提問

说明书
  • IGF-1 Receptor β/IGF1R抗体(D-11)是小鼠单克隆IgG2a (kappa轻链)，规格为200 µg/ml
  • 特异性抗原位于human物种的IGF-IR∫的C-terminus的氨基酸1333-1366之间
  • 推荐用于 mouse, rat， human 和 来源的IGF-IRβ WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： 和 equine, canine, bovine, porcine and avian
  • 看 IGF-1 Receptor β/IGF1R (F-1): sc-390130，可查看有标记的 IGF-1 Receptor β/IGF1R 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是IGF-1 Receptor β/IGF1R Antibody (D-11) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与IGF-1 Receptor β/IGF1R Antibody (D-11) 打包提供（请参阅下面的订购信息）。

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    描述
    基因信息
    说明书与实验方案
    研究信息

    関連項目

    附加IGF Receptor抗体，包括IGF-IR, IGF-IR α, IGF-IR β和IGF-IIR

    受体酪氨酸激酶（RTK）是跨膜分子支架，可影响细胞过程，包括细胞周期、细胞迁移、细胞代谢、细胞存活、增殖和分化。胰岛素样生长因子-I受体（IGF-IR）是一种RTK，可刺激多种不同细胞类型的生长，阻断细胞凋亡，作为多种生长激素反应的中间体，并可能刺激某些类型的癌症的生长。IGF-IR的同源配体胰岛素样生长因子-I（IGF-I）促进IGF-IR与Shc、GRB2和Sos1的结合，从而启动Ras和ERK激酶级联反应，从而改变转录因子活性，例如激活Elk转录因子。胰岛素受体底物（IRS）-1和-2的模块式磷酸酪氨酸结合（PTB）结构域可与活性IGF-IR结合，并启动磷脂酰肌醇3激酶依赖的下游信号。人类IGF-IR基因定位于染色体15q26.3，编码一个由1376个氨基酸组成的前体蛋白，该前体蛋白裂解为α和β亚基。人类IGF-IIR基因定位于染色体6q26，编码一个由2491个氨基酸组成的跨膜蛋白。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    IGF-1 Receptor β/IGF1R 抗体 (D-11)

    sc-398250
    200 µg/ml
    		RMB2377.00

    IGF-1 Receptor β/IGF1R (D-11): m-IgG Fc BP-HRP 套装

    sc-540924
    200 µg Ab; 10 µg BP
    		RMB2662.00

    IGF-1 Receptor β/IGF1R (D-11): m-IgG2a BP-HRP 套装

    sc-546979
    200 µg Ab; 10 µg BP
    		RMB2662.00

    IGF-1 Receptor β/IGF1R (D-11) 中和勝肽

    sc-398250 P
    100 µg/0.5 ml
    		RMB511.00

    What application is the blocking peptide sc-398250 P appropriate for?

    Asked by: AbPolly
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from A good antibody for a tricky membrane protein!I was trying to check the expression of IGF1R beta in sensory neurons, there are some reports in literature but not very clear and conclusive, so I was looking for a good antibody to verify the expression in sensory neurons by myself. Usually membrane proteins are tricky because they are embedded in membranes and IGF family proteins are highly homologous, so a highly specific clean antibody is very rare. The SCBT IGF-1R beta is a good antibody and it gave clear band that matched with theoretical mol. weight prediction in rat. The membrane bound signaling proteins tend to be modified post translation which shift their mass and charge, so do not get disappointed if the mol. weight does not precisely match with theoretical prediction. I attached my blot picture here to help you make up your mind. Cheers!
    Date published: 2017-05-05
    Rated 5 out of 5 by from Very good Western blot data of IGFVery good Western blot data of IGF-IR expression in HeLa and A-431 whole cell lysates. -SCBT QC
    Date published: 2014-02-05
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    IGF-1 Receptor β/IGF1R 抗体 (D-11) is rated 5.0 out of 5 by 2.
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