Date published: 2026-10-24

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IGF-1 Receptor α/IGF1R Antibody (G-5) - Western Blotting - Image 353360
IGF-IRα 抗体 (G-5): sc-271606. A-431 (A), MCF7 (B) 和 Hep G2 (C) 全细胞裂解液中 IGF-IRα 表达的 Western 印迹分析.
IGF-IRα 抗体 (G-5): sc-271606. A-431 (A), MCF7 (B) 和 Hep G2 (C) 全细胞裂解液中 IGF-IRα 表达的 Western 印迹分析.

IGF-1 Receptor α/IGF1R 抗体 (G-5): sc-271606

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说明书
  • IGF-1 Receptor α/IGF1R 抗体 G-5 是小鼠单克隆 IgG1 κ，IGF-1 Receptor α/IGF1R抗体, 在12篇文献中引用，规格为200 µg/ml
  • 免疫human物种的IGF-IRα的氨基酸123-200
  • IGF-1 Receptor α/IGF1R 抗体 (G-5) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 IGF-IRα
  • 抗IGF-1 Receptor α/IGF1R抗体（G-5）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是IGF-1 Receptor α/IGF1R Antibody (G-5) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与IGF-1 Receptor α/IGF1R Antibody (G-5) 打包提供（请参阅下面的订购信息）。
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附加IGF Receptor抗体，包括IGF-IR, IGF-IR α, IGF-IR β和IGF-IIR

IGF-IRα抗体（G-5）是一种IgG1 κ小鼠单克隆IGF-IRα抗体（也被称为IGF1R抗体、胰岛素样生长因子1受体抗体或CD221抗体），它可以通过WB、IP、IF、IHC（P）和ELISA检测来自小鼠、大鼠和人的IGF-IRα蛋白。IGF-IRα抗体（G-5）既有非偶联的抗IGF-IRα抗体形式，也有多种偶联形式的抗IGF-IRα抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。受体酪氨酸激酶（RTKs）是跨膜分子支架，可影响包括细胞周期、细胞迁移、细胞代谢、细胞存活、增殖和分化在内的细胞过程。胰岛素样生长因子-I受体（IGF-IR）是一种RTK，可刺激多种不同细胞类型的生长，阻止细胞凋亡，作为许多生长激素反应的中间体，并可能刺激某些类型的癌症的生长。IGF-IR的同源配体胰岛素样生长因子-I（IGF-I）促进IGF-IR与Shc、GRB2和Sos 1的结合，从而启动Ras和ERK激酶级联反应，进而改变转录因子活性，如激活Elk转录因子。胰岛素受体底物（IRS）-1和-2的模块化磷酸酪氨酸结合（PTB）结构域可与活化的IGF-IR结合，并启动磷脂酰肌醇3激酶依赖的下游信号。人类IGF-IR基因定位于染色体15q26.3，编码一个由1376个氨基酸组成的前体蛋白，该前体蛋白可裂解为α和β亚基。人类IGF-IIR基因定位于染色体6q26，编码一个由2491个氨基酸组成的跨膜蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IGF-1 Receptor α/IGF1R 抗体 (G-5) 参考文献:

  1. 胰岛素样生长因子 I 和 II 可诱导 Wilms 肿瘤细胞死亡。  |  Granérus, M., et al. 2001. Mol Pathol. 54: 30-5. PMID: 11212886
  2. 对不同抗雌激素的抵抗是由不同的多因素变化引起的，并与 IGF 受体 Ialpha 的表达减少有关。  |  Brockdorff, BL., et al. 2003. Endocr Relat Cancer. 10: 579-90. PMID: 14713268
  3. 一种新型选择性孕酮受体调节剂 Asoprisnil (J867) 能下调培养的子宫肌瘤细胞中 EGF, IGF-I, TGFbeta3 及其受体的表达。  |  Wang, J., et al. 2006. Hum Reprod. 21: 1869-77. PMID: 16613890
  4. 瘦素对人类乳腺癌细胞系的影响与雌激素受体和 HER2 状态的关系。  |  Ray, A., et al. 2007. Int J Oncol. 30: 1499-509. PMID: 17487372
  5. 胰岛素样生长因子 I 受体单克隆抗体对人类结直肠癌细胞生长的抑制作用。  |  Zhang, Y. and Zhang, Y. 2008. Cancer Invest. 26: 230-6. PMID: 18317963
  6. 自由采食、长期热量限制和间歇性热量限制MMTV-TGF-α小鼠血清胰岛素样生长因子-I与乳腺肿瘤发生的关系  |  Rogozina, OP., et al. 2009. Cancer Prev Res (Phila). 2: 712-9. PMID: 19654106
  7. 抗胰岛素样生长因子-I 受体单克隆抗体抑制肝癌细胞生长。  |  Yue, L., et al. 2012. Oncol Rep. 28: 1453-60. PMID: 22895605
  8. 催乳素通过调节与心脏肥大和增殖相关的信号通路，保护心肌细胞免受间歇性缺氧诱导的细胞损伤。  |  Hsieh, DJ., et al. 2015. Int J Cardiol. 181: 255-66. PMID: 25531577
  9. NOD/SCID小鼠人胶质母细胞瘤异种移植模型细胞表面受体的表达  |  Oh, KS., et al. 2002. Cancer Res Treat. 34: 52-7. PMID: 26680843
  10. 小鼠骨细胞分化过程中 IGFBP3 和 IGFBP5 对 IGF-I 的调控。  |  Aizawa, C., et al. 2019. J Oral Biosci. 61: 157-162. PMID: 31400542

订购信息

产品名称产品编号规格价格数量收藏夹

IGF-1 Receptor α/IGF1R 抗体 (G-5)

sc-271606
200 µg/ml
CNY2422.00

IGF-1 Receptor α/IGF1R (G-5): m-IgG Fc BP-HRP 套装

sc-527264
200 µg Ab; 10 µg BP
CNY2715.00

IGF-1 Receptor α/IGF1R (G-5): m-IgG1 BP-HRP 套装

sc-532637
200 µg Ab; 20 µg BP
CNY2715.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) AC

sc-271606 AC
500 µg/ml, 25% agarose
CNY3189.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) HRP

sc-271606 HRP
200 µg/ml
CNY2422.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) FITC

sc-271606 FITC
200 µg/ml
CNY2527.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) PE

sc-271606 PE
200 µg/ml
CNY2625.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 488

sc-271606 AF488
200 µg/ml
CNY2738.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 546

sc-271606 AF546
200 µg/ml
CNY2738.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 594

sc-271606 AF594
200 µg/ml
CNY2738.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 647

sc-271606 AF647
200 µg/ml
CNY2738.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 680

sc-271606 AF680
200 µg/ml
CNY2738.00

IGF-1 Receptor α/IGF1R 抗体 (G-5) Alexa Fluor® 790

sc-271606 AF790
200 µg/ml
CNY2738.00

Could I get a 10ul sample for the IGF1R alpha antibody sample?  GF-IRα Antibody (G-5) sc-271606 200 µg/ml $279.00 ADD TO CART

Asked by: Myungjun Ko
Thank you you for your request. Please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com, we would be happy to send you any samples you would like to try, including sc-271606.
Answered by: Tech Service
Date published: 2017-08-14

Can IGF-IRα (G-5): sc-271606 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, IGF-IRα (G-5): sc-271606 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by anemone from 検出できましたヒト横紋筋肉腫細胞株RD細胞抽出タンパク質を用いたWBでpro fromとmature formを検出できました
Date published: 2021-12-15
Rated 5 out of 5 by LauraPA from Good antibody against IGF-IRαThe antibody IGF-IRα (G-5) sc-271606 was tested in a L-MYC murine B cell lymphoma line at 1:50 dilution. Fc-receptor block was performed before surface staining.
Date published: 2019-04-04
Rated 5 out of 5 by Franck from très bon anticorpdétecte de façon très spécifique la forme pro et la chaine alpha d'IGF1R endogène et surexprimé dans les HEK293
Date published: 2018-04-16
Rated 5 out of 5 by maneeshi from Works great!Works for Immunofluorescence in hES cells at 1:50 dilution
Date published: 2018-03-01
Rated 4 out of 5 by 242526 from GoodThis antibody works well in western blotting experiments ofSW480 cell line
Date published: 2017-07-17
Rated 5 out of 5 by Germaine from Produced publishable WB data on humanThis IGF-IR monoclonal was referenced in a publication used in WB on SGC7901 cells
Date published: 2017-02-01
Rated 5 out of 5 by JM from Produced exceptional immunoperoxidase cytoplasmicProduced exceptional immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human heart muscle tissue. -SCBT QC
Date published: 2015-05-21
Rated 5 out of 5 by LF from LargeLarge, round band in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2014-05-16
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IGF-1 Receptor α/IGF1R 抗体 (G-5) is rated 4.9 out of 5 by 8.
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