Date published: 2025-9-8
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IDH1/2 Antibody (G-11) - Western Blotting - Image 149533
IDH1/2 抗体 (G-11): sc-373816. 大鼠心脏 (A) 和人类心脏 (B) 组织提取物中 IDH1/2 表达的 Western 印迹分析.
IDH1/2 抗体 (G-11): sc-373816. 大鼠心脏 (A) 和人类心脏 (B) 组织提取物中 IDH1/2 表达的 Western 印迹分析.

IDH1/2 抗体 (G-11): sc-373816

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说明书
  • IDH1/2 抗体 G-11 是小鼠单克隆 IgG1 κ，IDH1/2抗体, 在4篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的IDH2的内部区域内的氨基酸123-154之间
  • IDH1/2 抗体 (G-11) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ，检测 mouse, rat, human 和 来源的IDH1 and IDH2; 也和以下物种反应，包括： 和 equine, canine, bovine, porcine and avian
  • 抗IDH1/2抗体（G-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IDH1/2 (G-11): sc-373816的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 IDH1/2 抗体 (G-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与IDH1/2 抗体 (G-11) 组合成套装提供。 (请参阅下面的订购信息)。

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研究信息

関連項目

此外 IDH 抗体包括 和

IDH1/2抗体（G-11）是一种IgG1 κ小鼠单克隆IDH1/2抗体（也称为IDH1抗体、IDH2抗体、IDHC抗体、异柠檬酸脱氢酶（NADP+）1抗体、异柠檬酸脱氢酶（NADP+）2抗体、草酰琥珀酸脱羧酶抗体、NADP+特异性ICDH抗体、PICD抗体、IDH抗体、IDP抗体、NADP依赖性异柠檬酸脱氢酶过氧化物酶抗体、胞质NADP-异柠檬酸脱氢酶抗体、异柠檬酸脱氢酶1（NADP+）抗体或IDCD抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的IDH1/2蛋白。IDH1/2抗体（G-11）既可作为非共轭抗IDH1/2抗体形式，也可作为多种共轭形式的抗IDH1/2抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®共轭物。IDH2（异柠檬酸脱氢酶2（NADP+），线粒体），也被称为NADP+特异性ICDH；异柠檬酸脱氢酶，线粒体；以及草酰琥珀酸脱羧酶，是一种由人类IDH2基因编码的452个氨基酸的酶。IDH2属于异柠檬酸和异丙基苹果酸脱氢酶家族，包含两个核苷酸结合区。IDH2参与NADP+还原为NADPH的过程，并维持线粒体中谷胱甘肽（GSH）的供应。它被认为在中间代谢和能量产生中发挥作用。IDH2还与丙酮酸脱氢酶复合物紧密相关。IDH2在线粒体中以同源二聚体的形式存在，每个亚基可以结合一个镁离子或锰离子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IDH1/2 抗体 (G-11) 参考文献:

  1. 白血病IDH1和IDH2突变导致高甲基化表型，破坏TET2功能，并损害造血分化。  |  Figueroa, ME., et al. 2010. Cancer Cell. 18: 553-67. PMID: 21130701
  2. 异柠檬酸脱氢酶2通过基质金属蛋白酶7抑制胃癌细胞的侵袭。  |  Wu, D. 2016. Tumour Biol. 37: 5225-30. PMID: 26553362
  3. 依纳西尼在IDH2突变复发或难治性急性髓细胞白血病中的应用。  |  Stein, EM., et al. 2017. Blood. 130: 722-731. PMID: 28588020
  4. 异柠檬酸脱氢酶 2 型（IDH2）是胎盘类固醇生成过程中多蛋白复合物的一部分。  |  Urban-Sosa, VA., et al. 2019. Placenta. 87: 30-37. PMID: 31542634
  5. 野生型异柠檬酸脱氢酶2（IDH2）在乳腺癌中的预后意义。  |  Aljohani, AI., et al. 2020. Breast Cancer Res Treat. 179: 79-90. PMID: 31599393
  6. 异柠檬酸脱氢酶2缺乏会加剧长期高脂饮食摄入引起的高血压。  |  Noh, MR., et al. 2020. Redox Biol. 34: 101548. PMID: 32388270
  7. 异柠檬酸脱氢酶2（IDH2）R172突变型急性髓系白血病的治疗。  |  Linch, DC., et al. 2022. Br J Haematol. 196: 1348-1352. PMID: 34870324
  8. IDH2能稳定HIF-1α诱导的代谢重编程，并促进尿道癌的化疗耐受性。  |  Shigeta, K., et al. 2023. EMBO J. 42: e110620. PMID: 36637036
  9. 野生型IDH2是三阴性乳腺癌的治疗靶点。  |  Li, JJ., et al. 2024. Nat Commun. 15: 3445. PMID: 38658533
  10. 异柠檬酸脱氢酶2（IDH2）引起的癌症表观遗传失调。  |  Nayarisseri, A., et al. 2024. Adv Protein Chem Struct Biol. 141: 223-253. PMID: 38960475

订购信息

产品名称产品编号规格价格数量收藏夹

IDH1/2 抗体 (G-11)

sc-373816
200 µg/ml
RMB2377.00

IDH1/2 (G-11): m-IgG Fc BP-HRP 套装

sc-529576
200 µg Ab; 10 µg BP
RMB2662.00

IDH1/2 (G-11): m-IgGκ BP-HRP 套装

sc-522514
200 µg Ab, 40 µg BP
RMB2662.00

IDH1/2 (G-11): m-IgG1 BP-HRP 套装

sc-543591
200 µg Ab; 20 µg BP
RMB2662.00

IDH1/2 抗体 (G-11) AC

sc-373816 AC
500 µg/ml, 25% agarose
RMB3129.00

IDH1/2 抗体 (G-11) HRP

sc-373816 HRP
200 µg/ml
RMB2377.00

IDH1/2 抗体 (G-11) FITC

sc-373816 FITC
200 µg/ml
RMB2482.00

IDH1/2 抗体 (G-11) PE

sc-373816 PE
200 µg/ml
RMB2580.00

IDH1/2 抗体 (G-11) Alexa Fluor® 488

sc-373816 AF488
200 µg/ml
RMB2685.00

IDH1/2 抗体 (G-11) Alexa Fluor® 546

sc-373816 AF546
200 µg/ml
RMB2685.00

IDH1/2 抗体 (G-11) Alexa Fluor® 594

sc-373816 AF594
200 µg/ml
RMB2685.00

IDH1/2 抗体 (G-11) Alexa Fluor® 647

sc-373816 AF647
200 µg/ml
RMB2685.00

IDH1/2 抗体 (G-11) Alexa Fluor® 680

sc-373816 AF680
200 µg/ml
RMB2685.00

IDH1/2 抗体 (G-11) Alexa Fluor® 790

sc-373816 AF790
200 µg/ml
RMB2685.00

IDH1/2 (G-11) 中和勝肽

sc-373816 P
100 µg/0.5 ml
RMB511.00

Hello What mutations detects clone G11 of idh1/2

Asked by: Khaled
Thank you for your question. IDH1/2 Antibody (G-11): sc-373816 specific for an epitope mapping between amino acids 123-154 within an internal region of IDH2 of human origin. Mutations within this region may cause the antibody to no longer detect the protein. Mutations outside amino acids 123-154 may not have any impact on detection. Please contact our technical service to arrange for a sample of this antibody if you want to try out whether it is suitable for your application.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06

What application is the blocking peptide sc-373816 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from The IDH1 worked wellThe IDH1 Ab worked well in the WB analysis of human samples
Date published: 2024-09-17
Rated 1 out of 5 by from didn't workWe used this antibody for WB but approximately it didn't work as we planned. dillution 1/250
Date published: 2019-04-01
Rated 4 out of 5 by from Good for WBit works good for WB in our lab, not a bad choice.
Date published: 2017-09-18
Rated 5 out of 5 by from Worked wess in human tissueWe used this antibody for western blot staining and got a nice western blot at the correct molecular weight in human tissue
Date published: 2017-01-27
Rated 3 out of 5 by from IHC-PExtensive membrane signal in human decidua by IHC-P
Date published: 2016-12-25
Rated 5 out of 5 by from Clean bnads in western blot analysis of IDH1/2Clean bnads in western blot analysis of IDH1/2 expression in rat heart and human heart tissue extracts. -SCBT QC
Date published: 2015-06-21
Rated 5 out of 5 by from Beautiful immunoperoxidase cytoplasmic andBeautiful immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human urinary bladder tissue. -SCBT QC
Date published: 2015-01-19
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IDH1/2 抗体 (G-11) is rated 3.9 out of 5 by 7.
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