Date published: 2025-9-6
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HXK II Antibody (1A7) - Western Blotting - Image 65669
HXK II 抗体 (1A7): sc-130358. 293T 全细胞裂解液中 HXK II 表达的 Western 印迹分析.
HXK II Antibody (1A7) - Western Blotting - Image 65669
HXK II 抗体 (1A7): sc-130358. 293T 全细胞裂解液中 HXK II 表达的 Western 印迹分析.
HXK II Antibody (1A7) - Western Blotting - Image 54881
HXK II 抗体 (1A7): sc-130358. 非转染 293T: sc-117752 (A), 人 HXK II 转染 293T: sc-170641 (B) 和 HeLa (C) 全细胞裂解液中 HXK II 表达的 Western 印迹分析.
HXK II Antibody (1A7) - Western Blotting - Image 47897
HXK II 抗体 (1A7): sc-130358. Western 印迹分析 Jurkat 全细胞裂解液中 HXK II 的表达.
HXK II 抗体 (1A7): sc-130358. 293T 全细胞裂解液中 HXK II 表达的 Western 印迹分析.

HXK II 抗体 (1A7): sc-130358

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说明书
  • HXK II抗体(1A7)是小鼠单克隆IgG1 κ, 在24篇文献中引用，规格为50 µg/500 µl
  • 针对全长重组HXK II，human起源
  • 推荐用于 mouse, rat 和 human 来源的HXK II WB, IP 和 ELISA检测
  • 看 HXK II (B-8): sc-374091，可查看有标记的 HXK II 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 关于如何获取HXK II (1A7): sc-130358的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成HXK II 抗体 (1A7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 HXK 抗体 包括 HXK I, HXK II和HXK III

HXK II抗体（1A7）是一种IgG1 κ小鼠单克隆HXK II抗体，可通过WB、IP和ELISA检测小鼠、大鼠和人源的HXK II。HXK II抗体（1A7）为非偶联的抗HXK II抗体形式。己糖激酶利用Mg-ATP作为磷酸供体，催化细胞内葡萄糖代谢的第一步，即葡萄糖转化为葡萄糖-6-磷酸。已经鉴定出四种己糖激酶同工酶，包括己糖激酶I（HXK I）、己糖激酶II（HXK II）、己糖激酶III（HXK III）和己糖激酶IV（HXK IV，也称为葡萄糖激酶或GCK）。己糖激酶I-III各自包含一个N端疏水性氨基酸簇。葡萄糖激酶缺乏N端疏水性簇。该疏水性簇被认为对于膜结合是必要的。这得到了以下发现的证实：与其他己糖激酶相比，葡萄糖激酶对葡萄糖的亲和力较低。HXK I已被证明在脑、肾和心脏组织以及肝癌细胞系中表达。HXK II参与脂肪和骨骼组织对葡萄糖的摄取和利用。在己糖激酶中，HXK III对葡萄糖的亲和力最高。葡萄糖激酶在胰腺β细胞中表达，作为葡萄糖传感器发挥作用，决定胰岛素分泌的"设定点"。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HXK II 抗体 (1A7) 参考文献:

  1. HK2/己糖激酶-II整合糖酵解和自噬，从而保护细胞。  |  Tan, VP. and Miyamoto, S. 2015. Autophagy. 11: 963-4. PMID: 26075878
  2. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin.  |  DeWaal, D., et al. 2018. Nat Commun. 9: 446. PMID: 29386513
  3. SUMO化控制己糖激酶2与线粒体的结合，并防止前列腺癌的肿瘤形成。  |  Shangguan, X., et al. 2021. Nat Commun. 12: 1812. PMID: 33753739
  4. 癌症中的己糖激酶2：扮演多个角色的主角。  |  Ciscato, F., et al. 2021. Int J Mol Sci. 22: PMID: 33946854
  5. 周细胞中由 Hexokinase 2 驱动的糖酵解激活了它们的收缩力，导致肿瘤血管异常。  |  Meng, YM., et al. 2021. Nat Commun. 12: 6011. PMID: 34650057
  6. 小胶质细胞六碳糖激酶2缺乏通过脂质代谢增加ATP生成，导致β-淀粉样蛋白清除。  |  Leng, L., et al. 2022. Nat Metab. 4: 1287-1305. PMID: 36203054
  7. 己糖激酶2通过调节糖酵解通量和线粒体活性，在调节小胶质细胞功能方面发挥双重作用。  |  Hu, Y., et al. 2022. Nat Metab. 4: 1756-1774. PMID: 36536134
  8. Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease.  |  Fairley, LH., et al. 2023. Proc Natl Acad Sci U S A. 120: e2209177120. PMID: 36787364
  9. 肝星状细胞活化和肝纤维化需要通过组蛋白乳酰化介导的六碳糖激酶2基因表达。  |  Rho, H., et al. 2023. Cell Metab. 35: 1406-1423.e8. PMID: 37463576
  10. Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth.  |  Yan, H., et al. 2024. Cell Metab. 36: 2449-2467.e6. PMID: 39471815

订购信息

产品名称产品编号规格价格数量收藏夹

HXK II 抗体 (1A7)

sc-130358
50 µg/500 µl
$316.00

Could I have a 10 µg sample of your HXK II (1A7): sc-130358 to try out?

Asked by: Jesper
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-14

For Western Blot, is it recommended to use denatured or non-denatured conditions with HXK II (1A7): sc-130358 antibody?

Asked by: Germaine
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from HXK II (1A7)HXK II (1A7) worked great for western blot. Highly recommended. for Murine DCs
Date published: 2019-12-04
Rated 5 out of 5 by from It’s very good antibodyIt give me one single band corresponding to the right MW
Date published: 2018-05-15
Rated 5 out of 5 by from Great antibody for IP, WBI brought this antibody 3 month ago, it work great for me.
Date published: 2017-11-06
Rated 5 out of 5 by from Great antibody!The HXK II Antibody (1A7): sc-130358 provides great data for Western blot, showing clear band with minimal background.
Date published: 2017-01-17
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-06-08
Rated 4 out of 5 by from Nice band seen in WB using 293T whole cell lysateNice band seen in WB using 293T whole cell lysate. -SCBT QC
Date published: 2015-01-27
Rated 4 out of 5 by from CrispCrisp, strong band seen in WB using Jurkat whole cell lysate. -SCBT QC
Date published: 2013-08-01
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HXK II 抗体 (1A7) is rated 4.6 out of 5 by 7.
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