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hnRNP M3/4 Antibody (2A6) - Western Blotting - Image 373412
hnRNP M3/4 抗体 (2A6): sc-20001. HeLa (A), Jurkat (B), PC-12 (C), C6 (D) 和 RAW 264. 7 (E) 全细胞裂解液中 hnRNP M3/4 表达的 Western 印迹分析.
hnRNP M3/4 抗体 (2A6): sc-20001. HeLa (A), Jurkat (B), PC-12 (C), C6 (D) 和 RAW 264. 7 (E) 全细胞裂解液中 hnRNP M3/4 表达的 Western 印迹分析.

hnRNP M3/4 抗体 (2A6): sc-20001

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说明书
  • hnRNP M3/4抗体(2A6)是小鼠单克隆IgG1 κ, 在19篇文献中引用，规格为200 µg/ml
  • 针对由整个M4蛋白序列组成的融合蛋白的
  • 推荐用于 mouse, rat 和 human 来源的hnRNP M3 and hnRNP M4 WB, IP 和 IF检测; 也和以下物种反应，包括： 和 rabbit, bovine and porcine
  • 看 hnRNP M1-4 (1D8): sc-20002，可查看有标记的 hnRNP M3/4 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是hnRNP M3/4 Antibody (2A6) 适用于 WB 应用。 的首选辅助检测试剂，这些试剂现与hnRNP M3/4 Antibody (2A6) 打包提供（请参阅下面的订购信息）。

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関連項目

额外hnRNP抗体，包括hnRNP A, hnRNP A1, hnRNP A2, hnRNP B, hnRNP B1, hnRNP C1, hnRNP C2, hnRNP E1, hnRNP E2, hnRNP F, hnRNP H, hnRNP H3, hnRNP I, hnRNP J, hnRNP K和hnRNP L

异源核糖核蛋白（hnRNPs）构成了一组蛋白质，它们参与mRNA转录、前mRNA处理以及成熟mRNA转运到细胞质并进行翻译。它们还结合异源核RNA（hnRNA），即RNA聚合酶II产生的转录本。目前已知的hnRNP蛋白大约有20种，它们的复合物是剪接体的主要组成部分。大多数hnRNP蛋白组分定位于核内；然而，一些蛋白如hnRNP E1和E2可以在核与细胞质之间来回穿梭。hnRNP E1可能在细胞质中充当翻译调控蛋白，而hnRNP E2则可以稳定mRNA以增强脊灰病毒mRNA的翻译。hnRNP M参与前mRNA剪接以及应激诱导的短暂剪接停滞。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP M3/4 抗体 (2A6) 参考文献:

  1. 成肌细胞分化过程中受 p54nrb 和 hnRNPM 控制的启动子依赖性翻译  |  Ainaoui, N., et al. 2015. PLoS One. 10: e0136466. PMID: 26332123
  2. HnRNPM 和 CD44s 的表达会影响肿瘤的侵袭性，并预测伴有腋窝淋巴结转移的乳腺癌的不良预后。  |  Sun, H., et al. 2017. Genes Chromosomes Cancer. 56: 598-607. PMID: 28393427
  3. hnRNPM 是 YY1 促进前列腺癌细胞上皮-间充质转化的潜在媒介。  |  Yang, T., et al. 2019. Prostate. 79: 1199-1210. PMID: 31251827
  4. HNRNPM 控制 circRNA 的生物生成和剪接保真度，以维持癌细胞的健康。  |  Ho, JS., et al. 2021. Elife. 10: PMID: 34075878
  5. CircURI1与hnRNPM相互作用，通过调节胃癌的替代剪接抑制转移。  |  Wang, X., et al. 2021. Proc Natl Acad Sci U S A. 118: PMID: 34385309
  6. 靶向 HNRNPM 可抑制 Wnt 激活的肝细胞癌的癌干性并增强抗肿瘤免疫力  |  Zhu, GQ., et al. 2022. Cell Mol Gastroenterol Hepatol. 13: 1413-1447. PMID: 35158098
  7. 敲除 HNRNPM 可通过诱导铁变态反应抑制胶质瘤的进展。  |  Wang, J., et al. 2023. Cell Cycle. 22: 2264-2279. PMID: 38016815
  8. hnRNPM 通过抑制 LINE 相关的隐性剪接来防止 dsRNA 介导的干扰素反应。  |  Zheng, R., et al. 2024. Mol Cell. 84: 2087-2103.e8. PMID: 38815579
  9. PARP4 与 hnRNPM 相互作用，在肺癌进展过程中调控剪接。  |  Lee, YF., et al. 2024. Genome Med. 16: 91. PMID: 39034402
  10. FMRP 通过与 hnRNPM 相互作用促进 SLC7A11 的替代剪接，从而保护乳腺癌细胞免于铁变态反应。  |  Wang, N., et al. 2024. Redox Biol. 77: 103382. PMID: 39388855

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP M3/4 抗体 (2A6)

sc-20001
200 µg/ml
RMB2377.00

hnRNP M3/4 (2A6): m-IgG Fc BP-HRP 套装

sc-536638
200 µg Ab; 10 µg BP
RMB2662.00

hnRNP M3/4 (2A6): m-IgGκ BP-HRP 套装

sc-533795
200 µg Ab; 40 µg BP
RMB2662.00

For our customs, we need to know where the antibody hnRNP M3/4 Antibody (2A6): sc-20001 was produced in USA, in another country?

Asked by: Julie P
Thank you for your question. Yes, this antibody was produced in the USA.
Answered by: Tech Service
Date published: 2020-02-19

What is the recommended fixation method for immunofluorescence staining with hnRNP M3/4 (2A6): sc-20001 monoclonal antibody?

Asked by: Germaine
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Strong signal in WB in HeLa whole cell lysateStrong signal in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-04-24
Rated 5 out of 5 by from Published data for WB in human cancer cell linesPublished data for WB in human cancer cell lines. -SCBT Publication Review
Date published: 2015-04-16
Rated 5 out of 5 by from WB data published for use in human COSWB data published for use in human COS-7, HeLa, HEK293, 293T, and 293 cell lines. -SCBT Publication Review
Date published: 2015-04-10
Rated 4 out of 5 by from Worked for WB in human hnRNP M transfectedWorked for WB in human hnRNP M transfected 293 whole cell lysate. -SCBT QC
Date published: 2015-03-22
Rated 5 out of 5 by from Produced exceptional immunofluorescence nuclearProduced exceptional immunofluorescence nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-02-22
Rated 5 out of 5 by from Published IP and WB data in human HeLa andPublished IP and WB data in human HeLa and 293 T cells and rat hepatoma cells. -SCBT Publication Review
Date published: 2015-02-16
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hnRNP M3/4 抗体 (2A6) is rated 4.8 out of 5 by 6.
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