Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

HLA-E 抗体 (MEM-E/02): sc-51621

4.0(2)
寫評論提問

说明书
  • HLA-E 抗体 MEM-E/02 是小鼠单克隆 IgG1, 在7篇文献中引用,提供 100 µg/ml
  • 针对重组human HLA-E变性重链
  • 推荐用于 human 来源的denatured heavy chain of HLA-E WB, IP, IF 和 IHC(P)检测
  • 目前,我们还没有完成HLA-E 抗体 (MEM-E/02)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

関連項目

HLA-E抗体(MEM-E/02)是一种小鼠单克隆IgG1抗体,可通过多种应用检测人类样本中的HLA-E,包括蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学。HLA-E是免疫系统的重要组成部分,主要作为非经典主要组织相容性复合物(MHC)I类分子发挥作用,向自然杀伤(NK)细胞和CD8+ T淋巴细胞呈递一组有限的肽。这种选择性肽呈递对于免疫调节至关重要,因为HLA-E通过与NK细胞上的抑制性受体相互作用,从而调节其活性,在维持耐受性和预防自身免疫方面发挥着重要作用。HLA-E的结构由一个与β-2微球蛋白形成异二聚体的重链组成,这使得HLA-E能够与来自其他MHC I类分子的特定引导肽结合,从而促进健康细胞与受损或感染细胞之间的识别。通过了解HLA-E的复杂结构,研究人员可以更好地理解HLA-E在免疫监视中的重要性,以及对癌症和病毒感染等疾病的治疗干预的潜在意义。抗HLA-E抗体(MEM-E/02)是研究这些关键免疫过程的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

HLA-E 抗体 (MEM-E/02) 参考文献:

  1. 表达HLA-E的多能干细胞逃避NK细胞产生的同种异体反应和裂解。  |  Gornalusse, GG., et al. 2017. Nat Biotechnol. 35: 765-772. PMID: 28504668
  2. 衰老细胞通过 HLA-E 介导的 NK 和 CD8+ T 细胞抑制作用逃避免疫清除。  |  Pereira, BI., et al. 2019. Nat Commun. 10: 2387. PMID: 31160572
  3. 下调的细胞毒性CD8+ T细胞与NKG2A-可溶性HLA-E轴一起作为瘢痕疙瘩的预测生物标志物和潜在治疗靶标。  |  Xu, H., et al. 2022. Cell Mol Immunol. 19: 527-539. PMID: 35039632
  4. NKG2A和HLA-E在膀胱癌中定义了另一种免疫检查点轴。  |  Salomé, B., et al. 2022. Cancer Cell. 40: 1027-1043.e9. PMID: 36099881
  5. 免疫检查点HLA-E:CD94-NKG2A介导循环肿瘤细胞逃避NK细胞监视。  |  Liu, X., et al. 2023. Cancer Cell. 41: 272-287.e9. PMID: 36706761
  6. HLA-E的细胞内运输及其调节。  |  He, W., et al. 2023. J Exp Med. 220: PMID: 37140910
  7. HLA I类信号肽的多态性决定了CD94/NKG2-HLA-E介导的效应细胞反应调节水平。  |  Lin, Z., et al. 2023. Nat Immunol. 24: 1087-1097. PMID: 37264229
  8. HLA-E呈递的CD94/NKG2x配体的高通量表征揭示了调节NK细胞活化的肽。  |  Huisman, BD., et al. 2023. Nat Commun. 14: 4809. PMID: 37558657
  9. 针对HIV和流感的抗原特异性记忆NK细胞反应利用NKG2/HLA-E轴。  |  Jost, S., et al. 2023. Sci Immunol. 8: eadi3974. PMID: 38064568
  10. 靶向氨基肽酶ERAP通过破坏NKG2A-HLA-E抑制性检查点增强抗肿瘤免疫。  |  Tsao, HW., et al. 2024. Immunity. 57: 2863-2878.e12. PMID: 39561763

订购信息

产品名称产品编号规格价格数量收藏夹

HLA-E 抗体 (MEM-E/02)

sc-51621
100 µg/ml
RMB2377.00

Hi, do you have trial size volume available for sc-51621? We need to make sure that the antibody works before we buy the regular vial. Thanks

Asked by: msaeed
Thank you for your question. Unfortunately, we do not offer this particular antibody in sample size. However, we do offer our warranty on WB, IP, IF and IHC(P) with samples of human origin.
Answered by: Tech Support Europe
Date published: 2020-08-28

I would like to use HLA-E (MEM-E/02): sc-51621 for immunoprecipitation. Which protein agarose do you recommend using with this antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend using Protein A/G PLUS-Agarose: sc-2003 https://www.scbt.com/scbt/product/protein-a-g-plus-agarose
Answered by: Technical Support
Date published: 2017-04-12
  • y_2025, m_9, d_6, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_51621, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Produced good WB data with AMLProduced good WB data with AML-193, CCRF-CEM and MEG-01 whole cell lysates. -SCBT QC
Date published: 2015-04-14
Rated 4 out of 5 by from WB positive data in KWB positive data in K-562, BJAB, human PBL and HL-60 whole cell lysates. -SCBT QC
Date published: 2014-09-30
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_51621, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 18ms
  • REVIEWS, PRODUCT
HLA-E 抗体 (MEM-E/02) is rated 4.0 out of 5 by 2.
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_51621, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 109ms
  • REVIEWS, PRODUCT