Date published: 2026-10-24

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Histone Deacetylase 3 (HDAC3) Antibody (B-12) - Western Blotting - Image 1405
HDAC3 抗体 (B-12): sc-17795. Jurkat (A), K-562 (B), A-431 (C) 和 NIH/3T3 (D) 核提取物中 HDAC3 表达的 Western 印迹分析.
Histone Deacetylase 3 (HDAC3) Antibody (B-12) - Western Blotting - Image 1405
HDAC3 抗体 (B-12): sc-17795. Jurkat (A), K-562 (B), A-431 (C) 和 NIH/3T3 (D) 核提取物中 HDAC3 表达的 Western 印迹分析.
HDAC3 抗体 (B-12): sc-17795. Jurkat (A), K-562 (B), A-431 (C) 和 NIH/3T3 (D) 核提取物中 HDAC3 表达的 Western 印迹分析.

Histone Deacetylase 3 (HDAC3) 抗体 (B-12): sc-17795

4.3(6)
寫評論提問
说明书
  • Histone Deacetylase 3 (HDAC3)抗体(B-12)是小鼠单克隆IgG2a κ, 在28篇文献中引用，规格为200 µg/ml
  • 免疫human来源HDAC3位于C-terminus 的330-428氨基酸
  • 抗-Histone Deacetylase 3 (HDAC3) 抗体 (B-12) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 HDAC3; 也和以下物种反应，包括： 和 equine, canine, bovine and porcine
  • 抗Histone Deacetylase 3 (HDAC3)抗体（B-12）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是Histone Deacetylase 3 (HDAC3) Antibody (B-12) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Histone Deacetylase 3 (HDAC3) Antibody (B-12) 打包提供（请参阅下面的订购信息）。
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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外HDAC抗体，包括HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8和HDAC9

HDAC3抗体（B-12）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过应用诸如蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠和人类样本中的组蛋白去乙酰化酶3（HDAC3）。抗HDAC3抗体（B-12）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。HDAC3通过去除组蛋白上的乙酰基来调节基因表达，从而起到关键作用，这会导致染色质凝结和转录抑制。这种脱乙酰化过程对于维持细胞内环境平衡和调节各种生物过程至关重要，包括细胞周期进展、细胞分化以及细胞凋亡。HDAC3的失调与多种疾病有关，包括癌症，其中异常的组蛋白脱乙酰化会导致肿瘤抑制基因沉默。了解HDAC3的功能及其与组蛋白乙酰转移酶GCN5和p300等其他蛋白的相互作用，对于阐明基因表达的复杂调控网络以及开发与表观遗传修饰相关的疾病靶向疗法至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) 参考文献:

  1. 微生物群衍生的代谢物促进肠道HDAC3活性。  |  Wu, SE., et al. 2020. Nature. 586: 108-112. PMID: 32731255
  2. HOXB13通过HDAC3介导的前列腺癌表观遗传重编程抑制新脂肪生成  |  Lu, X., et al. 2022. Nat Genet. 54: 670-683. PMID: 35468964
  3. 心外膜 HDAC3 通过新型 MicroRNA 通路促进心肌生长  |  Jang, J., et al. 2022. Circ Res. 131: 151-164. PMID: 35722872
  4. HDAC3在Kras突变型非小细胞肺癌的肿瘤发展和治疗抵抗中至关重要。  |  Eichner, LJ., et al. 2023. Sci Adv. 9: eadd3243. PMID: 36930718
  5. HDAC3缺乏通过维持线粒体质量控制来保持上皮屏障完整性，从而保护急性肺损伤。  |  Li, N., et al. 2023. Redox Biol. 63: 102746. PMID: 37244125
  6. TGF-β1/SMAD3 通过抑制 HDAC3 调节程序性细胞死亡 5，从而抑制心肌梗死后的心脏纤维化。  |  Weng, L., et al. 2023. Circ Res. 133: 237-251. PMID: 37345556
  7. HDAC3和HDAC8 PROTAC双降解剂揭示了组蛋白乙酰化在基因调控中的作用。  |  Xiao, Y., et al. 2023. Cell Chem Biol. 30: 1421-1435.e12. PMID: 37572669
  8. HDAC3 畸变导致的 GPX4 抑制推动了肾脏铁变态反应和 AKI-CKD 进展。  |  Zhang, L., et al. 2023. Redox Biol. 68: 102939. PMID: 37890360
  9. 阻止坏种子：HDAC3调节缺血性中风后不同小胶质细胞的增殖。  |  Zhang, Y., et al. 2024. Sci Adv. 10: eade6900. PMID: 38446877
  10. TRAP1通过HDAC3介导的组蛋白H4赖氨酸12的乳酰化驱动平滑肌细胞衰老并促进动脉粥样硬化。  |  Li, X., et al. 2024. Eur Heart J. 45: 4219-4235. PMID: 39088352

订购信息

产品名称产品编号规格价格数量收藏夹

Histone Deacetylase 3 抗体 (B-12)

sc-17795
200 µg/ml
CNY2422.00

Histone Deacetylase 3 (HDAC3) (B-12): m-IgG Fc BP-HRP 套装

sc-525487
200 µg Ab; 10 µg BP
CNY2715.00

Histone Deacetylase 3 (HDAC3) (B-12): m-IgG2a BP-HRP 套装

sc-546282
200 µg Ab; 10 µg BP
CNY2715.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) AC

sc-17795 AC
500 µg/ml, 25% agarose
CNY3189.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) HRP

sc-17795 HRP
200 µg/ml
CNY2422.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) FITC

sc-17795 FITC
200 µg/ml
CNY2527.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) PE

sc-17795 PE
200 µg/ml
CNY2625.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 488

sc-17795 AF488
200 µg/ml
CNY2738.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 546

sc-17795 AF546
200 µg/ml
CNY2738.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 594

sc-17795 AF594
200 µg/ml
CNY2738.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 647

sc-17795 AF647
200 µg/ml
CNY2738.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 680

sc-17795 AF680
200 µg/ml
CNY2738.00

Histone Deacetylase 3 (HDAC3) 抗体 (B-12) Alexa Fluor® 790

sc-17795 AF790
200 µg/ml
CNY2738.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 7
Date published: 2017-02-08
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Rated 5 out of 5 by cjMara from Very popular HDAC3 clone!This mouse monoclonal, HDAC3 Antibody (B-12 is a very popular choice and has been featured in 15 publications for a variety of research applications including WB, IP and ChIP.
Date published: 2017-01-26
Rated 3 out of 5 by Basudev Chowdhury from WB correct mw sized band~49 KDa band observed by WB on 10 ug MDA-MB-231 whole cell lysates at 1:1000 dilution. 3 more unidentifiable bands visible.
Date published: 2016-12-12
Rated 4 out of 5 by HH from This has worked very well in WB&IP with RAW264This has worked very well in WB&IP with RAW264.7 cells.
Date published: 2015-11-19
Rated 5 out of 5 by FL from Publishable data in coimmunoprecipitationPublishable data in coimmunoprecipitation and Western blotting with this antibody -SCBT Publication Review
Date published: 2015-02-10
Rated 5 out of 5 by LM from This antibody works in many different humanThis antibody works in many different human cell lines such as MCF10A, MCF7, A431 and Raji. -SCBT Publication Review
Date published: 2015-01-08
Rated 4 out of 5 by NZ from Good specificity and signal strength withGood specificity and signal strength with some background bands -SCBT QC
Date published: 2013-01-20
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Histone Deacetylase 3 (HDAC3) 抗体 (B-12) is rated 4.3 out of 5 by 6.
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