Date published: 2025-9-8

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GPVI 抗体 (H-5): sc-390410

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说明书
  • GPVI 抗体 H-5 是小鼠单克隆 IgG2b (kappa轻链),GPVI抗体,规格为200 µg/ml
  • 免疫human物种的GPVI的氨基酸201-339
  • GPVI 抗体 (H-5) 推荐用于WB, IP, IF 和 ELISA,检测mouse, rat, human 来源的 GPVI-1, GPVI-2 and GPVI-3
  • 抗GPVI抗体(H-5)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取GPVI (H-5): sc-390410免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2b BP-HRP">m-IgG2b BP-HRP是GPVI Antibody (H-5) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与GPVI Antibody (H-5) 打包提供(请参阅下面的订购信息)。

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関連項目

GPVI抗体(H-5)是一种IgG2b κ小鼠单克隆GPVI抗体(也称为GPVI抗体),能够通过WB、IP、IF和ELISA检测到来源于小鼠、大鼠和人类的GPVI蛋白。GPVI抗体(H-5)既有无偶联的抗GPVI抗体形式,也有多种偶联形式的抗GPVI抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。CD32(也称为Fc gamma RII)是聚集IgG的Fc片段的低亲和力受体。CD32负责巨噬细胞清除免疫复合物,并在B细胞抗体产生的调节中发挥重要作用。作为免疫球蛋白超家族的成员,糖蛋白VI(GPVI)是一种胶原受体,在胶原诱导的血小板聚集中发挥关键作用。GPVI缺乏的患者会患上出血性疾病,GPVI可能与心血管和脑血管疾病有关。GPVI还结合胶原相关肽(CRP)和Convulxin(Cvx),一种来自蛇毒的GPVI特异性配体。GPVI通过CD32传递信号,响应Cvx,导致Syk和PLCg2的酪氨酸磷酸化和激活。编码人类GPVI的基因位于19q13染色体上,产生三种异构体,全长GPVI-1和另外两种异构体GPVI-2和GPVI-3。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GPVI 抗体 (H-5) 参考文献:

  1. 昆虫细胞中产生的可溶性人 Fc γ 受体 II(CD32)异构体的表征和结晶。  |  Sondermann, P., et al. 1999. Biochemistry. 38: 8469-77. PMID: 10387093
  2. 被糖蛋白 VI 选择性配体 convulxin 激活的血小板中用于激活 T 细胞的连接蛋白与多种适配蛋白的相互作用。  |  Asazuma, N., et al. 2000. J Biol Chem. 275: 33427-34. PMID: 10942756
  3. 人和小鼠糖蛋白 VI 的克隆, 表征和功能研究:免疫球蛋白超家族中血小板特异性胶原蛋白受体。  |  Jandrot-Perrus, M., et al. 2000. Blood. 96: 1798-807. PMID: 10961879
  4. 血小板胶原受体糖蛋白 VI 的分子克隆, 基因组结构, 染色体定位和替代剪接形式。  |  Ezumi, Y., et al. 2000. Biochem Biophys Res Commun. 277: 27-36. PMID: 11027634
  5. 巨核细胞成熟过程中胶原蛋白受体 GPVI 的表达和功能  |  Lagrue-Lak-Hal, AH., et al. 2001. J Biol Chem. 276: 15316-25. PMID: 11278467
  6. 血小板与胶原蛋白的相互作用离不开糖蛋白 VI 而非 alpha2beta1 整合素。  |  Nieswandt, B., et al. 2001. EMBO J. 20: 2120-30. PMID: 11331578

订购信息

产品名称产品编号规格价格数量收藏夹

GPVI 抗体 (H-5)

sc-390410
200 µg/ml
RMB2377.00

GPVI (H-5): m-IgG Fc BP-HRP 套装

sc-526157
200 µg Ab; 10 µg BP
RMB2662.00

GPVI (H-5): m-IgG2b BP-HRP 套装

sc-549687
200 µg Ab; 10 µg BP
RMB2662.00

GPVI 抗体 (H-5) AC

sc-390410 AC
500 µg/ml, 25% agarose
RMB3129.00

GPVI 抗体 (H-5) HRP

sc-390410 HRP
200 µg/ml
RMB2377.00

GPVI 抗体 (H-5) FITC

sc-390410 FITC
200 µg/ml
RMB2482.00

GPVI 抗体 (H-5) PE

sc-390410 PE
200 µg/ml
RMB2580.00

GPVI 抗体 (H-5) Alexa Fluor® 488

sc-390410 AF488
200 µg/ml
RMB2685.00

GPVI 抗体 (H-5) Alexa Fluor® 546

sc-390410 AF546
200 µg/ml
RMB2685.00

GPVI 抗体 (H-5) Alexa Fluor® 594

sc-390410 AF594
200 µg/ml
RMB2685.00

GPVI 抗体 (H-5) Alexa Fluor® 647

sc-390410 AF647
200 µg/ml
RMB2685.00

GPVI 抗体 (H-5) Alexa Fluor® 680

sc-390410 AF680
200 µg/ml
RMB2685.00

GPVI 抗体 (H-5) Alexa Fluor® 790

sc-390410 AF790
200 µg/ml
RMB2685.00

Hello, I am interested in your GPVI (H-5): sc-390410 antibody. Can I get sample of it? Thank you, Kristina

Asked by: KristinaB
Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Support
Date published: 2019-04-25

I need to use an antibody to detect the protein in samples of avian origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 3
Date published: 2017-02-14
  • y_2025, m_9, d_6, h_5CST
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Rated 5 out of 5 by from Strong and CleanGreat results in Western Blot: single clean band seen with no background.
Date published: 2017-01-16
Rated 1 out of 5 by from This antibody did not detect GPVI from humanThis antibody did not detect GPVI from human platelet lysate in western blot.
Date published: 2015-12-16
Rated 5 out of 5 by from Good Western Blot data of GPVI expression in MEGGood Western Blot data of GPVI expression in MEG-01 whole cell lysate. -SCBT QC
Date published: 2015-02-16
Rated 5 out of 5 by from Great Western Blot data of GPVI expression in KGreat Western Blot data of GPVI expression in K-562 whole cell lysate. -SCBT QC
Date published: 2014-07-06
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GPVI 抗体 (H-5) is rated 4.0 out of 5 by 4.
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