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gankyrin 抗体 (A-8): sc-166376

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说明书
  • gankyrin抗体(A-8)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长gankyrin的氨基酸1-231
  • 推荐用于 mouse, rat 和 human 来源的gankyrin WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是gankyrin Antibody (A-8) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与gankyrin Antibody (A-8) 打包提供(请参阅下面的订购信息)。

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関連項目

Gankyrin,一种与肝细胞癌相关的蛋白质,在细胞周期控制和蛋白质降解中调节蛋白质-蛋白质相互作用。此外,在正常肝细胞中,gankyrin的上调也与细胞周期进展相关。它包含六个被称为锚蛋白重复的结构域,并与Rb、Cdk4、26S蛋白酶体和MAGE-A4相互作用。最后一种相互作用抑制了gankyrin过表达细胞中的非锚定依赖性生长,这为肝细胞癌的免疫治疗提供了一种可能的机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

gankyrin 抗体 (A-8) 参考文献:

  1. Gankyrin介导的去分化促进大鼠肝细胞和肝癌细胞的肿瘤形成。  |  Sun, W., et al. 2011. Hepatology. 54: 1259-72. PMID: 21735473
  2. Gankyrin通过PI3K/AKT/HIF-1α/cyclin D1途径促进卵泡刺激素驱动的卵巢癌细胞增殖。  |  Chen, J., et al. 2016. Oncogene. 35: 2506-17. PMID: 26364616
  3. 非小细胞肺癌中Gankyrin蛋白表达的临床病理特征和预后意义。  |  Wang, WP., et al. 2015. Pathol Res Pract. 211: 939-47. PMID: 26554593
  4. Gankyrin 在肝细胞癌中通过对 Nrf2 的反馈调节发挥抗氧化作用。  |  Yang, C., et al. 2016. J Exp Med. 213: 859-75. PMID: 27091842
  5. Gankyrin促进胃癌的增殖,并与化疗敏感性相关。  |  Zeng, YC., et al. 2017. Tumour Biol. 39: 1010428317704820. PMID: 28653901
  6. Gankyrin 可诱导肿瘤微环境中的 STAT3 激活和肝细胞癌的索拉非尼耐药性。  |  Sakurai, T., et al. 2017. Cancer Sci. 108: 1996-2003. PMID: 28777492
  7. Gankyrin 通过加速结直肠癌中 TSC2 的降解来激活 mTORC1 信号。  |  Sakurai, T., et al. 2019. Digestion. 100: 192-200. PMID: 30513515
  8. 探索gankyrin在癌症发展中的作用及其作为治疗靶标的潜力。  |  Kanabar, D. and Muth, A. 2020. Future Med Chem. 12: 1603-1606. PMID: 32892644
  9. Gankyrin作为隐匿性肝转移结直肠癌的潜在生物标志物。  |  Wang, C., et al. 2021. Front Oncol. 11: 656852. PMID: 34395241
  10. PSMD10Gankyrin 上可容纳界面肽和多柔比星的药物口袋。  |  M G, MS., et al. 2022. Eur J Pharmacol. 915: 174718. PMID: 34953804

订购信息

产品名称产品编号规格价格数量收藏夹

gankyrin 抗体 (A-8)

sc-166376
200 µg/ml
RMB2377.00

gankyrin (A-8): m-IgG Fc BP-HRP 套装

sc-537480
200 µg Ab; 10 µg BP
RMB2662.00

gankyrin (A-8): m-IgGκ BP-HRP 套装

sc-534759
200 µg Ab; 40 µg BP
RMB2662.00

What is the recommended fixation method for immunofluorescence staining with gankyrin (A-8): sc-166376 monoclonal antibody?

Asked by: Trav11
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Produced exceptional immunofluorescence nuclearProduced exceptional immunofluorescence nuclear and cytoplasmic staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-01-02
Rated 5 out of 5 by from Great Western Blot data of gankyrin expressionGreat Western Blot data of gankyrin expression in non-transfected 293T, mouse gankyrin transfected 293T and HeLa whole cell lysates. -SCBT QC
Date published: 2013-03-08
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gankyrin 抗体 (A-8) is rated 5.0 out of 5 by 2.
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