Date published: 2025-9-7

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galectin-4 抗体 (B-9): sc-271533

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说明书
  • galectin-4抗体(B-9)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于mouse物种的galectin-4的内部区域内的氨基酸129-187之间
  • 推荐用于 mouse 来源的galectin-4 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是galectin-4 Antibody (B-9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与galectin-4 Antibody (B-9) 打包提供(请参阅下面的订购信息)。

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    関連項目

    半乳凝素是一类可溶性β-半乳糖苷结合的动物凝集素,可调节细胞间粘附和细胞与细胞外基质(ECM)的相互作用,并在肿瘤进展、mRNA前体剪接和细胞凋亡中发挥作用。这个家族的一个成员,半乳凝素-4,也被称为Gal-4、L36或LGALS4,位于人类染色体19q13.2。半乳凝素-4蛋白由323个氨基酸组成,含有两个同源的碳水化合物识别结构域(CRD)和半乳凝素家族中通常保守的所有氨基酸。半乳凝素-4的表达与人肝细胞癌(HCC)的恶性潜能相关,并且根据细胞间接触、血清生长因子、细胞生长和细胞分化状态而受到不同调节。半乳凝素-4在结肠、直肠和肠的上皮细胞以及HT29和LS174T细胞系中表达。半乳糖凝集素-4在结直肠癌癌症中表达不足,在易于腹膜扩散的细胞中优先上调。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    galectin-4 抗体 (B-9) 参考文献:

    1. 小鼠半乳糖凝集素4的碳水化合物识别结构域在寡糖结合和表位识别中的作用,以及小鼠细胞和组织中半乳糖凝集素4和半乳糖凝集素6的表达。  |  Marková, V., et al. 2006. Int J Mol Med. 18: 65-76. PMID: 16786157
    2. 胶质蛋白-4参与髓磷脂碱性蛋白启动子的p27介导激活。  |  Wei, Q., et al. 2007. J Neurochem. 101: 1214-23. PMID: 17403142
    3. 凝集素-4是一种新型的神经元髓鞘调节因子。  |  Stancic, M., et al. 2012. Glia. 60: 919-35. PMID: 22431161
    4. 神经胶质蛋白-4是轴突生长以及轴突膜L1递送和聚集的必要条件。  |  Velasco, S., et al. 2013. J Neurochem. 125: 49-62. PMID: 23311731
    5. 减弱 galectin-4 的表达可促进结直肠癌的肿瘤发生。  |  Kim, SW., et al. 2013. Cell Oncol (Dordr). 36: 169-78. PMID: 23378274
    6. 凝集素-4的磷酸化与外化受Src家族激酶控制。  |  Ideo, H., et al. 2013. Glycobiology. 23: 1452-62. PMID: 24013903
    7. 神经元通过调节含半乳糖凝集素-4的轴突膜结构域来定义非髓鞘轴突段。  |  Díez-Revuelta, N., et al. 2017. Sci Rep. 7: 12246. PMID: 28947766
    8. 胶质蛋白-4是少突胶质细胞分化的负调控因子,在多发性硬化病变的轴突和微胶质细胞/巨噬细胞中持续存在。  |  de Jong, CGHM., et al. 2018. J Neuropathol Exp Neurol. 77: 1024-1038. PMID: 30252090
    9. B3GALT5的高表达抑制了低分化胃癌细胞中由半乳糖凝集素4介导的腹膜转移。  |  Tsuchida, A., et al. 2024. Glycobiology. 34: PMID: 39163480
    10. Galectin-4 和 galectin-6 是在小鼠胃肠道中表达的两种密切相关的凝集素。  |  Gitt, MA., et al. 1998. J Biol Chem. 273: 2954-60. PMID: 9446608

    订购信息

    产品名称产品编号规格价格数量收藏夹

    galectin-4 抗体 (B-9)

    sc-271533
    200 µg/ml
    RMB2377.00

    galectin-4 (B-9): m-IgG Fc BP-HRP 套装

    sc-537656
    200 µg Ab; 10 µg BP
    RMB2662.00

    galectin-4 (B-9): m-IgGκ BP-HRP 套装

    sc-534990
    200 µg Ab; 40 µg BP
    RMB2662.00

    galectin-4 (B-9): m-IgG2a BP-HRP 套装

    sc-548079
    200 µg Ab; 10 µg BP
    RMB2662.00

    galectin-4 (B-9) 中和勝肽

    sc-271533 P
    100 µg/0.5 ml
    RMB511.00

    Is there any cross-reactivity on mouse galectin-6? The amino acid sequences of galectin-4 and galectin-6 are very similar, while exhibiting differences in link region of galectin-4 (aa 161-184).

    Asked by: iglee
    Thank you for your question. Please see link for more information : https://www.uniprot.org/uniprotkb/Q8K419/entry
    Answered by: BlakeJ
    Date published: 2024-03-28

    What application is the blocking peptide sc-271533 P appropriate for?

    Asked by: Dr Ninau Qelp
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced positive Western Blot data of galectinProduced positive Western Blot data of galectin-4 expression in non-transfected and mouse galectin-4 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2015-04-05
    Rated 5 out of 5 by from Satisfactory Western Blot data of galectinSatisfactory Western Blot data of galectin-4 expression in mouse cerebellum and rat cerebellum tissue extracts. -SCBT QC
    Date published: 2014-09-20
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    galectin-4 抗体 (B-9) is rated 5.0 out of 5 by 2.
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