Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

epsin 1 抗体 (A-9): sc-166354

5.0(3)
寫評論提問

说明书
  • epsin 1抗体(A-9)是小鼠单克隆IgG3 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于rat物种的epsin 1的C-terminus附近的氨基酸523-552之间
  • 推荐用于 mouse, rat 和 human 来源的epsin 1 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG3 BP-HRP是epsin 1 Antibody (A-9) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂,该试剂现与epsin 1 Antibody (A-9) 搭配使用(请参阅下面的订购信息)。

    快捷链接

    関連項目

    Epsin 1(EPN1)是一种内吞辅助蛋白,与Xenopus有丝分裂磷蛋白MP90具有显著相似性。Epsin 1与Eps15(网格蛋白适配器AP2的α亚基)、网格蛋白和其他辅助蛋白相互作用。这些蛋白的有丝分裂磷酸化可能是有丝分裂中网格蛋白包被凹坑内陷被阻断的机制之一。Epsin和Eps15与其他突触囊泡内吞机制的胞质组分一样,在神经末梢经历组成性磷酸化和去极化依赖性去磷酸化。Epsin 1还有助于网格蛋白-囊泡依赖性内吞作用的机制。人类Epsin 1蛋白包含一个epsin N端同源(ENTH)区域和一个单一的网格蛋白结合(LVDLD)基序。Epsin 1定位于囊泡包被凹坑的前缘,即膜正在积极弯曲的地方。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    epsin 1 抗体 (A-9) 参考文献:

    1. 内细胞蛋白质的核胞质穿梭。  |  Vecchi, M., et al. 2001. J Cell Biol. 153: 1511-7. PMID: 11425879
    2. 淀粉样前体蛋白的Flotillin依赖性聚类调节其在神经元中的内吞和淀粉样形成过程。  |  Schneider, A., et al. 2008. J Neurosci. 28: 2874-82. PMID: 18337418
    3. 依赖分泌酶的γ裂解从质膜上启动缺口信号传递。  |  Sorensen, EB. and Conner, SD. 2010. Traffic. 11: 1234-45. PMID: 20573067
    4. 神经元活动与凝集素组装蛋白 AP180 的表达  |  Wu, F., et al. 2010. Biochem Biophys Res Commun. 402: 297-300. PMID: 20937255
    5. 利用分子传感器对细胞脂质进行原位定量成像。  |  Yoon, Y., et al. 2011. Nat Chem. 3: 868-74. PMID: 22024883
    6. 预泛素化的嵌合 ErbB2 会被组成型内吞,随后在溶酶体中降解。  |  Vuong, TT., et al. 2013. Exp Cell Res. 319: 32-45. PMID: 23127513
    7. Epsin 1 通过提高运动神经元细胞核中的 BMP 信号水平促进突触生长  |  Vanlandingham, PA., et al. 2013. PLoS One. 8: e65997. PMID: 23840387
    8. 膜蛋白和蛋白-蛋白相互作用的协同作用控制着epsin 1的膜重塑,并影响着凝集素介导的内吞作用。  |  Kroppen, B., et al. 2021. Cell Mol Life Sci. 78: 2355-2370. PMID: 32997199
    9. Epsin-1 N 终止子螺旋肽的结构剖析:疏水基在调节膜曲率中的作用。  |  Nishimura, M., et al. 2023. Chemistry. 29: e202300129. PMID: 36878866
    10. 检测膜重塑和曲率感应的单粒子分析方法。  |  Colussi, A., et al. 2024. J Cell Sci. 137: PMID: 39324332

    订购信息

    产品名称产品编号规格价格数量收藏夹

    epsin 1 抗体 (A-9)

    sc-166354
    200 µg/ml
    RMB2377.00

    epsin 1 (A-9): m-IgG3 BP-HRP 套装

    sc-551980
    200 µg Ab; 40 µg BP
    RMB2662.00

    epsin 1 (A-9) 中和勝肽

    sc-166354 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-166354 P appropriate for?

    Asked by: AbPolly
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-27
    • y_2025, m_9, d_7, h_4CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_166354, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 118ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Strong band in WB in AStrong band in WB in A-431, NIH/3T3 and KNRK whole cell lysates. -SCBT QC
    Date published: 2015-07-14
    Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
    Date published: 2015-02-22
    Rated 5 out of 5 by from Robust signal in WB in Jurkat whole cell lysateRobust signal in WB in Jurkat whole cell lysate. -SCBT QC
    Date published: 2015-01-10
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_166354, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 8ms
    • REVIEWS, PRODUCT
    epsin 1 抗体 (A-9) is rated 5.0 out of 5 by 3.
    • y_2025, m_9, d_7, h_4
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_166354, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 105ms
    • REVIEWS, PRODUCT