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EGF 抗体 (H-3): sc-271090

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说明书
  • EGF抗体(H-3)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的EGF的C-terminus的氨基酸984-1017之间
  • 推荐用于 human 来源的precursor and mature EGF WB, IP, IF 和 ELISA检测
  • 看 EGF (F-9): sc-166779,可查看有标记的 EGF 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是EGF Antibody (H-3) for WB applications. 的首选辅助检测试剂,这些试剂现与EGF Antibody (H-3) 打包提供(请参阅下面的订购信息)。
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表皮生长因子(EGF)是一种耐酸和耐热的53个氨基酸的蛋白质,最初在啮齿动物和人类中发现。体内和体外实验均表明,它对多种细胞类型具有强效的促有丝分裂作用。EGF与细胞表面的EGF受体结合,并介导受体在酪氨酸残基上的内在磷酸化。已在几乎所有的体液中检测到它,如尿液(尿抑胃素)、唾液、牛奶和富血小板血浆。EGF、TGFα和牛痘病毒生长因子具有30-40%的氨基酸同源性。已描述了EGF/TGF家族的几个额外成员,这些包括Cripto、Amphiregulin和肝素结合的EGF样生长因子。Amphiregulin和肝素结合的EGF样生长因子都与EGF受体结合。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

EGF 抗体 (H-3) 参考文献:

  1. 在衰老细胞中,EGF信号通过溶酶体受体减少。  |  Park, WY., et al. 2001. Ann N Y Acad Sci. 928: 79-84. PMID: 11795531
  2. EGF受体作为癌症治疗的目标。  |  Mendelsohn, J. 2004. Trans Am Clin Climatol Assoc. 115: 249-53; discussion 253-4. PMID: 17060971
  3. EGF受体抑制减轻高尿酸血症肾病。  |  Liu, N., et al. 2015. J Am Soc Nephrol. 26: 2716-29. PMID: 25788532
  4. 靶向EGF的肽阻断EGF-EGFR相互作用。  |  Guardiola, S., et al. 2016. Chembiochem. 17: 702-11. PMID: 26677067
  5. EGF促进胶质细胞祖细胞向少突胶质细胞的转化。  |  Yang, J., et al. 2017. Front Mol Neurosci. 10: 106. PMID: 28442994
  6. EGF信号传导促进星形胶质细胞向少突胶质细胞的转化。  |  Liu, X., et al. 2022. Mol Med. 28: 50. PMID: 35508991
  7. 用于检测EGF和EGF刺激Ca2+信号的基于细胞的传感器。  |  Lee, E., et al. 2023. Biosensors (Basel). 13: PMID: 36979595
  8. NRF2通过OTUD4调节EGF在肺腺癌中的稳定性。  |  Hu, S., et al. 2024. Biochem Biophys Res Commun. 708: 149798. PMID: 38518721
  9. 表皮生长因子(EGF)、EGF受体和c-erbB-2在人类胃癌中的临床意义。  |  Tokunaga, A., et al. 1995. Cancer. 75: 1418-25. PMID: 7889468
  10. 肿瘤和转移中的EGF受体。  |  Khazaie, K., et al. 1993. Cancer Metastasis Rev. 12: 255-74. PMID: 8281612

订购信息

产品名称产品编号规格价格数量收藏夹

EGF 抗体 (H-3)

sc-271090
200 µg/ml
CNY2422.00

EGF (H-3): m-IgG Fc BP-HRP 套装

sc-540200
200 µg Ab; 10 µg BP
CNY2715.00

EGF (H-3): m-IgG1 BP-HRP 套装

sc-541967
200 µg Ab; 20 µg BP
CNY2715.00

EGF (H-3) 中和勝肽

sc-271090 P
100 µg/0.5 ml
CNY519.00

What application is the blocking peptide sc-271090 P appropriate for?

Asked by: Trav11
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by JL from Good Western Blot data of EGF expressionGood Western Blot data of EGF expression in human platelet extract. -SCBT QC
Date published: 2013-07-30
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EGF 抗体 (H-3) is rated 5.0 out of 5 by 1.
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