Date published: 2026-10-24

1-800-457-3801

SCBT Portrait Logo
Seach Input

E2F-4 抗体 (TFE-42): sc-56668

5.0(3)
寫評論提問
说明书
  • E2F-4抗体(TFE-42)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对全长E2F-4,human起源
  • 推荐用于 mouse, rat 和 human 来源的E2F-4 WB, IP, IF 和 ELISA检测
  • 看 E2F-4 (D-7): sc-398543,可查看有标记的 E2F-4 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是E2F-4 Antibody (TFE-42) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与E2F-4 Antibody (TFE-42) 打包提供(请参阅下面的订购信息)。
    Gene Editing Promo Banner

    快捷链接

    関連項目

    人视网膜母细胞瘤基因产物可能在细胞增殖的负调控中发挥重要作用。Rb的功能失活可以通过突变或由与DNA肿瘤病毒编码的蛋白质相互作用引起。在迄今为止描述的所有Rb关联中,Rb与转录因子E2F之间复合物的鉴定最直接地将Rb与细胞增殖的调控联系起来。E2F最初是通过其在腺病毒E2启动子的转录激活中的作用而被鉴定的。在许多编码细胞周期G1和S期假定功能的蛋白质的基因的上游发现了与E2F结合位点同源的序列。E2F-1是包括E2F-2、E2F-3、E2F-4、E2F-5、E2F-6和E2F-7在内的更广泛的转录调节因子家族的成员,每个成员都与第二种蛋白质DP-1形成异二聚体,形成"活性"的E2F转录调节复合物。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    E2F-4 抗体 (TFE-42) 参考文献:

    1. 单纯疱疹病毒诱导 E2F4 在细胞内的重新分布和 E2F 口袋蛋白复合物的积累。  |  Olgiate, J., et al. 1999. Virology. 258: 257-70. PMID: 10366563
    2. 人类转录因子基因E2F-4编码区中各种AGC重复数。  |  Zhong, X., et al. 2000. Hum Mutat. 15: 296-7. PMID: 10679953
    3. 通过异位表达E2F-4的依赖半胱天冬酶的细胞凋亡。  |  Chang, YC., et al. 2000. Oncogene. 19: 4713-20. PMID: 11032021
    4. 腺病毒 E4-6/7 蛋白通过富含精氨酸的基团引导 E2F-4 的核定位。  |  Schaley, JE., et al. 2005. J Virol. 79: 2301-8. PMID: 15681431
    5. 通过全基因组分析揭示E2F4在转录激活和抑制中的广泛功能。  |  Lee, BK., et al. 2011. Nucleic Acids Res. 39: 3558-73. PMID: 21247883
    6. E2F4 可独立于 RB 家族调控小鼠胚胎干细胞的转录激活。  |  Hsu, J., et al. 2019. Nat Commun. 10: 2939. PMID: 31270324
    7. E2F4通过上调CDCA3促进肝细胞癌细胞的增殖。  |  Liu, J., et al. 2021. J Cancer. 12: 5173-5180. PMID: 34335934
    8. E2F4诱导的AGAP2-AS1上调通过miR-182-5p/CFL1轴加速结肠直肠癌的进展。  |  Guo, Z., et al. 2022. Dig Liver Dis. 54: 878-889. PMID: 34838479
    9. E2F4的突变体在5xFAD小鼠中引发多因素治疗效应。  |  López-Sánchez, N., et al. 2022. Mol Neurobiol. 59: 3016-3039. PMID: 35254651
    10. 原发性人类胃肠道肿瘤中E2F-4细胞周期基因的频繁突变。  |  Souza, RF., et al. 1997. Cancer Res. 57: 2350-3. PMID: 9192806

    订购信息

    产品名称产品编号规格价格数量收藏夹

    E2F-4 抗体 (TFE-42)

    sc-56668
    200 µg/ml
    CNY2422.00

    E2F-4 (TFE-42): m-IgG Fc BP-HRP 套装

    sc-537112
    200 µg Ab; 10 µg BP
    CNY2715.00

    E2F-4 (TFE-42): m-IgGκ BP-HRP 套装

    sc-534304
    200 µg Ab; 40 µg BP
    CNY2715.00

    What is the recommended starting dilution for Western blot for E2F-4 (TFE-42): sc-56668 monoclonal antibody?

    Asked by: cjMara
    Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-56668.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
    Answered by: Technical Support
    Date published: 2017-03-01
    • y_2026, m_10, d_23, h_6CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.48
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_56668, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 78ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by JT from Good WB band in mouse transfected 293T wholeGood WB band in mouse transfected 293T whole cell lysates. -SCBT QC
    Date published: 2015-05-13
    Rated 5 out of 5 by SM from Worked well in WB in RajiWorked well in WB in Raji, NIH/3T3 and Jurkat whole cell lysates. -SCBT QC
    Date published: 2015-05-05
    Rated 5 out of 5 by JL from Single strong band in WB in Y79 and ASingle strong band in WB in Y79 and A-431nuclear extracts and Raji whole cell lysate. -SCBT QC
    Date published: 2014-05-05
    • y_2026, m_10, d_23, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_56668, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 8ms
    • REVIEWS, PRODUCT
    E2F-4 抗体 (TFE-42) is rated 5.0 out of 5 by 3.
    • y_2026, m_10, d_23, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_56668, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 78ms
    • REVIEWS, PRODUCT