Date published: 2025-9-8
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DDX17 Antibody (C-9) - Western Blotting - Image 357997
DDX17 抗体 (C-9): sc-271112. C6 (A), MCF7 (B), K-562 (C), A-431 (D), HEK293T (E) 和 HeLa (F) 全细胞裂解液中 DDX17 表达的 Western 印迹分析.
DDX17 抗体 (C-9): sc-271112. C6 (A), MCF7 (B), K-562 (C), A-431 (D), HEK293T (E) 和 HeLa (F) 全细胞裂解液中 DDX17 表达的 Western 印迹分析.

DDX17 抗体 (C-9): sc-271112

5.0(5)
寫評論提問

说明书
  • DDX17抗体(C-9)是小鼠单克隆IgG1 κ, 在7篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列485-641位于human物种的DDX17的C-terminus附近
  • 推荐用于 mouse, rat 和 human 来源的DDX17 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是DDX17 Antibody (C-9) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与DDX17 Antibody (C-9) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外DDX抗体，包括DDX1, DDX11, DDX15, DDX16, DDX17, DDX21, DDX25, DDX27, DDX29, DDX3, DDX30, DDX32, DDX33, DDX34, DDX36和DDX38

DEAD盒蛋白以保守基序Asp-Glu-Ala-Asp为特征，是公认的RNA解旋酶，与涉及RNA二级结构修饰的几个细胞过程有关。具体而言，DEAD-box蛋白参与翻译起始、细胞核和线粒体剪接以及核糖体和剪接体组装。根据其分布模式，该家族的成员可能参与胚胎发生、精子发生以及细胞生长和分裂。DDX17（DEAD盒蛋白17），也称为p72，与DDX5（p68）高度同源。DDX17和DDX5通过作为多种转录因子的转录共调节剂参与生长调节，包括ERα、p53、MyoD和Runx2。DDX17的损伤可能影响早期大脑发育，并可能导致唐氏综合症。或者，DDX17和DDX5的上调直接导致结肠癌癌症，这表明DDX17可能是对抗癌症的有用治疗靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

DDX17 抗体 (C-9) 参考文献:

  1. miRNA生物发生和DDX17在肿瘤发生和癌症干细胞中的作用。  |  Wu, KJ. 2020. Biomed J. 43: 107-114. PMID: 32513392
  2. RNA 解旋酶 DDX17 通过阻断病毒前基因组 RNA 包膜抑制乙型肝炎病毒复制。  |  Mao, R., et al. 2021. J Virol. 95: e0044421. PMID: 34287051
  3. DDX17调控的替代剪接产生了PXN-AS1的致癌异构体，从而促进了HCC转移。  |  Zhou, HZ., et al. 2022. Hepatology. 75: 847-865. PMID: 34626132
  4. DDX17保护肝细胞免受油酸/棕榈酸诱导的脂质积累。  |  Zhang, X., et al. 2022. Biochem Biophys Res Commun. 612: 169-175. PMID: 35533489
  5. DDX5和DDX17-多面蛋白在肿瘤发生和肿瘤进展中的调节作用。  |  Xu, K., et al. 2022. Front Oncol. 12: 943032. PMID: 35992805
  6. DDX17促进肺腺癌的生长和转移。  |  Liu, X., et al. 2022. Cell Death Discov. 8: 425. PMID: 36273228
  7. DDX17 螺旋酶促进解决人体细胞中 R 环介导的转录复制冲突。  |  Boleslavska, B., et al. 2022. Nucleic Acids Res. 50: 12274-12290. PMID: 36453994
  8. DDX17通过miR-149-3p/CYBRD1通路诱导结直肠癌的上皮-间质转化和转移  |  Zhao, G., et al. 2023. Cell Death Dis. 14: 1. PMID: 36593242
  9. DNA解旋酶DDX5和DDX17促进感染人肝细胞中HBV转录终止的异质性。  |  Chapus, F., et al. 2024. J Hepatol. 81: 609-620. PMID: 38782119
  10. DEAD-box 螺旋酶17（DDX17）通过促进心力衰竭中的线粒体稳态来保护心脏功能。  |  Yan, M., et al. 2024. Signal Transduct Target Ther. 9: 127. PMID: 38782919

订购信息

产品名称产品编号规格价格数量收藏夹

DDX17 抗体 (C-9)

sc-271112
200 µg/ml
RMB2377.00

DDX17 (C-9): m-IgG Fc BP-HRP 套装

sc-540206
200 µg Ab; 10 µg BP
RMB2662.00

DDX17 (C-9): m-IgG1 BP-HRP 套装

sc-541969
200 µg Ab; 20 µg BP
RMB2662.00

I am using DDX17 (C-9): sc-271112 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jenniferc
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Beautiful staining data!This monoclonal DDX17 Antibody (C-9) gives beautiful staining data in formalin fixed, paraffin-embedded human rectum tissue showing nuclear staining of glandular cells.
Date published: 2017-02-08
Rated 5 out of 5 by from Robust signal in WB in LADMAC whole cell lysatesRobust signal in WB in LADMAC whole cell lysates. -SCBT QC
Date published: 2015-05-24
Rated 5 out of 5 by from Good specificity in WB in Jurkat whole cell lysateGood specificity in WB in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-05-21
Rated 5 out of 5 by from Strong band in WB in NIH/3T3 and HeLa wholeStrong band in WB in NIH/3T3 and HeLa whole cell lysates. -SCBT QC
Date published: 2015-04-17
Rated 5 out of 5 by from Great immunoperoxidase nuclear staining inGreat immunoperoxidase nuclear staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
Date published: 2015-04-09
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DDX17 抗体 (C-9) is rated 5.0 out of 5 by 5.
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