Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

CYP7A1 抗体 (E-10): sc-518007

4.0(2)
寫評論提問

说明书
  • CYP7A1抗体(E-10)是小鼠单克隆IgG1 κ, 在22篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的的内部区域内的氨基酸86-108之间
  • 抗-CYP7A1 抗体 (E-10) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 CYP7A1
  • 抗CYP7A1抗体(E-10)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CYP7A1 (E-10): sc-518007免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是CYP7A1 Antibody (E-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CYP7A1 Antibody (E-10) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

CYP7A1抗体(E-10)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类样本中的CYP7A1。Anti-CYP7A1抗体(E-10)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。CYP7A1,也称为胆固醇7α-羟化酶,在肝脏胆汁酸合成中起着关键作用,是限制反应速度的酶,这一过程对于消化和吸收膳食脂肪和脂溶性维生素至关重要。CYP7A1的表达主要由胆汁酸受体FXR调节,后者对体内的胆汁酸水平作出反应,确保代谢反应平衡。CYP7A1失调会导致多种代谢紊乱,包括胆固醇胆结石和肝功能障碍,这凸显了CYP7A1在维持脂质稳态方面的重要性。CYP7A1与参与胆固醇代谢的其他蛋白相互作用,进一步凸显了CYP7A1在更广泛的代谢途径中的重要性,这使得CYP7A1单克隆抗体(E-10)成为研究脂质代谢和相关疾病的研究人员的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CYP7A1 参考文献:

  1. 胆固醇7α-羟化酶(CYP7A1)在营养遗传学和降低胆固醇的药理学中的作用。  |  Hubacek, JA. and Bobkova, D. 2006. Mol Diagn Ther. 10: 93-100. PMID: 16669607
  2. CYP7A1:肝脏昼夜节律输出调节睡眠中断的代谢效应。  |  Oster, H. 2015. Cell Mol Gastroenterol Hepatol. 1: 574-575. PMID: 28210701
  3. 乳酸杆菌介导NPC1L1、CYP7A1和ABCG5基因的表达,以调节胆固醇。  |  Cao, K., et al. 2021. Food Sci Nutr. 9: 6882-6891. PMID: 34925816
  4. 缺乏 Cyp7a1 和 Cyp27a1 的雌性小鼠的胆汁酸稳态。  |  Rizzolo, D., et al. 2021. Acta Pharm Sin B. 11: 3847-3856. PMID: 35024311
  5. 通过槲皮素靶向mTOR/YY1信号通路,通过CYP7A1介导的胆固醇-胆汁酸转化减轻2型糖尿病引起的肝脂质积累。  |  Yang, T., et al. 2023. Phytomedicine. 113: 154703. PMID: 36889164
  6. 荟萃分析CYP7A1单核苷酸多态性对血清脂质对他汀类药物反应的综合影响。  |  Lim, MYC., et al. 2023. Front Genet. 14: 1199549. PMID: 37377593
  7. 胆固醇7α-羟化酶(CYP7A1)的药理调节作为高胆固醇血症的治疗策略。  |  Yu Cai Lim, M. and Kiat Ho, H. 2024. Biochem Pharmacol. 220: 115985. PMID: 38154545
  8. 通过PPARα介导的CYP7A1激活抑制PCSK9,预防和缓解胆固醇胆结石。  |  Chen, Z., et al. 2024. Metabolism. 152: 155774. PMID: 38191052
  9. 薯蓣皂苷元作为胆固醇的替代物,通过影响CYP7A1和NPC1L1相关途径减轻NAFLD。  |  Yan, M., et al. 2024. Phytomedicine. 125: 155299. PMID: 38301301
  10. 通过SHP依赖或独立机制诱导的CYP7A1基因可增加药物性肝损伤的风险,且可单独或与BSEP抑制协同作用。  |  Niu, C., et al. 2024. Drug Metab Dispos. 52: 432-441. PMID: 38485279

订购信息

产品名称产品编号规格价格数量收藏夹

CYP7A1 抗体 (E-10)

sc-518007
200 µg/ml
RMB2377.00

CYP7A1 (E-10): m-IgG Fc BP-HRP 套装

sc-531590
200 µg Ab; 10 µg BP
RMB2662.00

CYP7A1 (E-10): m-IgGκ BP-HRP 套装

sc-525321
200 µg Ab, 40 µg BP
RMB2662.00

CYP7A1 (E-10): m-IgG1 BP-HRP 套装

sc-544644
200 µg Ab; 20 µg BP
RMB2662.00

CYP7A1 抗体 (E-10) AC

sc-518007 AC
500 µg/ml, 25% agarose
RMB3129.00

CYP7A1 抗体 (E-10) HRP

sc-518007 HRP
200 µg/ml
RMB2377.00

CYP7A1 抗体 (E-10) FITC

sc-518007 FITC
200 µg/ml
RMB2482.00

CYP7A1 抗体 (E-10) PE

sc-518007 PE
200 µg/ml
RMB2580.00

CYP7A1 抗体 (E-10) Alexa Fluor® 488

sc-518007 AF488
200 µg/ml
RMB2685.00

CYP7A1 抗体 (E-10) Alexa Fluor® 546

sc-518007 AF546
200 µg/ml
RMB2685.00

CYP7A1 抗体 (E-10) Alexa Fluor® 594

sc-518007 AF594
200 µg/ml
RMB2685.00

CYP7A1 抗体 (E-10) Alexa Fluor® 647

sc-518007 AF647
200 µg/ml
RMB2685.00

CYP7A1 抗体 (E-10) Alexa Fluor® 680

sc-518007 AF680
200 µg/ml
RMB2685.00

CYP7A1 抗体 (E-10) Alexa Fluor® 790

sc-518007 AF790
200 µg/ml
RMB2685.00

一抗CYP7A1(sc-518007)用于WB推荐的稀释比;动物:小鼠肝脏组织。

Asked by: maqiaolian
CYP7A1 (E-10)推荐用WB(Western blot)检测小鼠、大鼠和人来源的CYP7A1(起始稀释度为1∶100,稀释范围为1∶100 ~ 1∶1000)。 CYP7A1 (E-10) is recommended for detection of CYP7A1 of mouse, rat and human origin by Western Blotting (starting dilution 1:100, dilution range 1:100-1:1000).
Answered by: Zhanglong
Date published: 2025-08-07
  • y_2025, m_9, d_7, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_518007, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 104ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Great Antibody to detect human CYP7A1Antibody shows a strong 58 KDa Western Blot band with a transfected lysate that over-expresses human CYP7A1 (Right lane). Transfected Lysate's NCBI Reference Sequence: NM_000780.4 -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by from Moderate results with Huh7 cell lysatesTested on Western blot on whole cell lysate (from Huh7 cell line).The antibody is specific for Cyp7A1, but the background is high. Application: Western blot Sample: whole lysate of human hepatocytes from Huh7 cell line Gel running conditions: reduced, denaturing, 4-12% SDS-PAGE Loading amount: 30 µg protein/lane Transfer: semi-dry, on nitrocellulose membrane (0.45 µm) Blocking agent: 5% milk in TBST buffer, for 1h, RT Primary antibody dilution- 1: 400 in 5% milk, for 16 h at 4°C Secondary antibody: non- Santa Cruz antibody anti-mouse-HRP, 1:10000 dilution in 5% milk, for 1h, RT Detection: ECL substrate (femto sensitivity) Exposure time: 9 sec Bands: specific, at 58 kDa; non-specific bands are absent.
Date published: 2023-08-04
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_518007, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 19ms
  • REVIEWS, PRODUCT
CYP7A1 抗体 (E-10) is rated 4.0 out of 5 by 2.
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_518007, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 113ms
  • REVIEWS, PRODUCT