Date published: 2025-9-7
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CYP1B1 Antibody (G-4) - Western Blotting - Image 149484
CYP1B1 抗体 (G-4): sc-374228. 非转染: sc-117752 (A) 和人 CYP1B1 转染: sc-158414 (B) 293T 全细胞裂解液中 CYP1B1 表达的 Western 印迹分析.
CYP1B1 Antibody (G-4) - Western Blotting - Image 149484
CYP1B1 抗体 (G-4): sc-374228. 非转染: sc-117752 (A) 和人 CYP1B1 转染: sc-158414 (B) 293T 全细胞裂解液中 CYP1B1 表达的 Western 印迹分析.
CYP1B1 抗体 (G-4): sc-374228. 非转染: sc-117752 (A) 和人 CYP1B1 转染: sc-158414 (B) 293T 全细胞裂解液中 CYP1B1 表达的 Western 印迹分析.

CYP1B1 抗体 (G-4): sc-374228

3.6(7)
寫評論提問

说明书
  • CYP1B1 抗体 G-4 是小鼠单克隆 IgG1 κ，CYP1B1抗体, 在18篇文献中引用，规格为200 µg/ml
  • 针对human起源的CYP1B1内部区域内的氨基酸221-325进行
  • CYP1B1 抗体 (G-4) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 CYP1B1
  • 抗CYP1B1抗体（G-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CYP1B1 (G-4): sc-374228的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 1 BP-HRP">m-IgG1 BP-HRP是CYP1B1 Antibody (G-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与CYP1B1 Antibody (G-4) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外CYP抗体，包括CYP11B, CYP17A1, CYP19, CYP1A1, CYP1A2, CYP1B1, CYP24, CYP26A1, CYP27A1, CYP27B1, CYP2A6, CYP2B1, CYP2C6, CYP2D6, CYP2F1和CYP2F2

CYP1B1抗体（G-4）是一种IgG1 κ小鼠单克隆CYP1B1抗体（也称为P4501B1抗体、CYPIB1抗体、CP1B抗体、细胞色素P450家族1亚家族B成员1抗体、细胞色素P450、亚家族I、多肽1抗体、氢过氧基二十碳四烯酸脱水酶抗体、黄素蛋白连接的单加氧酶抗体、芳烃羟化酶抗体、微粒体单加氧酶抗体或眼前节发育不良6（ASGD6）抗体），可通过WB、IP、IF和ELISA检测人类来源的CYP1B1蛋白。CYP1B1抗体（G-4）既可以是非偶联的抗CYP1B1抗体形式，也可以是多种偶联形式的抗CYP1B1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。细胞色素P450 1B1（CYP1B1）是参与潜在致癌雌激素代谢物产生和环境致癌物激活的关键酶，并且是正常乳腺组织和乳腺癌中表达的CYP1家族的主要成员。雌激素已被提出通过涉及其代谢物儿茶酚雌激素（CE）的引发机制触发乳腺癌的发展。CYP1B1催化17-β-雌二醇转化为儿茶酚雌激素代谢物2-OH-E2和4-OH-E2，这两种代谢物都被假定参与乳腺致癌作用。CYP1B1的基因多态性在人类前列腺癌的发生中也可能起重要作用。CYP1B1基因第432位密码子（Val-->Leu）的多态性与催化功能的改变有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CYP1B1 抗体 (G-4) 参考文献:

  1. 人类 CYP1B1 Leu432Val 基因多态性：在非裔美国人, 白种人和中国人中的种族分布；雌二醇羟化酶活性；以及在前列腺癌病例和对照组中的分布。  |  Tang, YM., et al. 2000. Pharmacogenetics. 10: 761-6. PMID: 11221602
  2. CYP1B1 多态性与乳腺癌风险的关系  |  De Vivo, I., et al. 2002. Cancer Epidemiol Biomarkers Prev. 11: 489-92. PMID: 12010864
  3. 土耳其人群中细胞色素 P450 CYP1B1 和邻苯二酚 O-甲基转移酶 (COMT) 遗传多态性与乳腺癌易感性。  |  Kocabaş, NA., et al. 2002. Arch Toxicol. 76: 643-9. PMID: 12415427
  4. 细胞色素 P450-1B1 基因多态性与环境污染物在乳腺癌风险中的相互作用  |  Saintot, M., et al. 2004. Eur J Cancer Prev. 13: 83-6. PMID: 15075793
  5. 细胞色素 P450 1B1 (CYP1B1) 多态性与乳腺癌中类固醇受体状态的缔合作用。  |  Bailey, LR., et al. 1998. Cancer Res. 58: 5038-41. PMID: 9823305

订购信息

产品名称产品编号规格价格数量收藏夹

CYP1B1 抗体 (G-4)

sc-374228
200 µg/ml
RMB2377.00

CYP1B1 (G-4): m-IgG1 BP-HRP 套装

sc-531711
200 µg Ab; 20 µg BP
RMB2662.00

CYP1B1 抗体 (G-4) AC

sc-374228 AC
500 µg/ml, 25% agarose
RMB3129.00

CYP1B1 抗体 (G-4) HRP

sc-374228 HRP
200 µg/ml
RMB2377.00

CYP1B1 抗体 (G-4) FITC

sc-374228 FITC
200 µg/ml
RMB2482.00

CYP1B1 抗体 (G-4) PE

sc-374228 PE
200 µg/ml
RMB2580.00

CYP1B1 抗体 (G-4) Alexa Fluor® 488

sc-374228 AF488
200 µg/ml
RMB2685.00

CYP1B1 抗体 (G-4) Alexa Fluor® 546

sc-374228 AF546
200 µg/ml
RMB2685.00

CYP1B1 抗体 (G-4) Alexa Fluor® 594

sc-374228 AF594
200 µg/ml
RMB2685.00

CYP1B1 抗体 (G-4) Alexa Fluor® 647

sc-374228 AF647
200 µg/ml
RMB2685.00

CYP1B1 抗体 (G-4) Alexa Fluor® 680

sc-374228 AF680
200 µg/ml
RMB2685.00

CYP1B1 抗体 (G-4) Alexa Fluor® 790

sc-374228 AF790
200 µg/ml
RMB2685.00

hi, i purchase 4 vials of thus and i could not detect band in mcf-7 and t47d ,mda-231 .mda-468 please could yoy help me in this issue as i did not want to change it to other compny please advise me best regards, hend

Asked by: deem
Thank you for your question. Please contact our Technical Service Department for assistance in troubleshooting this antibody.
Answered by: Technical Support
Date published: 2019-05-20

Can CYP1B1 (G-4): sc-374228 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Professor Griffin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CYP1B1 (G-4): sc-374228 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Works well for WB!Worked well when using for WB at 1:200 dilution. Provided nice clear bands in both human and mouse tissue lysates.
Date published: 2018-03-22
Rated 1 out of 5 by from Doesn't work for immunofluorescence on mouse cellsUsed on mouse ovarian epithelial cells at 1/100 overnight at 4C then 1/500 goat α-mouse secondary for 1H at room temp. No signal detected.
Date published: 2017-03-24
Rated 1 out of 5 by from Ne fonctionne pas chez la sourisNe fonctionne ni en WB sur des extraits de testicules de souris ni en immunohistochimie sur des testicules de souris
Date published: 2017-02-02
Rated 5 out of 5 by from Excellent choice for CYP1B1!Great antibody for CYP1B1 detection: strong and specific, highly reliable.
Date published: 2017-01-20
Rated 4 out of 5 by from Working well so farWorking well so far.
Date published: 2015-06-15
Rated 5 out of 5 by from Worked with human transfected lysate by WBWorked with human transfected lysate by WB -SCBT QC
Date published: 2015-01-12
Rated 5 out of 5 by from Western blot publishable data in human liverWestern blot publishable data in human liver tissue. -SCBT Publication Review
Date published: 2013-04-06
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CYP1B1 抗体 (G-4) is rated 3.6 out of 5 by 7.
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