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creatine kinase-M/B Antibody (BDI937) - Western Blotting - Image 17570
肌酸激酶-M/B 抗体 (BDI937): sc-56895. 对 SH-SY5Y (A) 和 HeLa (B) 全细胞裂解液中肌酸激酶-M/B 的表达进行 Western 印迹分析.
creatine kinase-M/B Antibody (BDI937) - Western Blotting - Image 17570
肌酸激酶-M/B 抗体 (BDI937): sc-56895. 对 SH-SY5Y (A) 和 HeLa (B) 全细胞裂解液中肌酸激酶-M/B 的表达进行 Western 印迹分析.
肌酸激酶-M/B 抗体 (BDI937): sc-56895. 对 SH-SY5Y (A) 和 HeLa (B) 全细胞裂解液中肌酸激酶-M/B 的表达进行 Western 印迹分析.

creatine kinase-M/B 抗体 (BDI937): sc-56895

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说明书
  • creatine kinase-M/B 抗体 BDI937 是小鼠单克隆 IgG1，提供 100 µg/ml
  • 针对creatine kinase-M/B dimer，human来源的二聚体
  • 推荐用于 human 来源的creatine kinase-M/B WB, IP 和 ELISA检测
  • 目前，我们还没有完成creatine kinase-M/B 抗体 (BDI937)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    此外 Creatine Kinase 抗体包括 creatine kinase-B 和 creatine kinase-M

    肌酸激酶（CKs）是一个大的同工酶家族，它们在亚细胞区室内调节ATP的水平。通过在肌酸和腺嘌呤核苷酸之间转移磷酸盐，它们在有波动能量需求的位点提供ATP。肌酸激酶为驱动许多细胞系统的正常功能提供了必要的磷酸水解能量，这些细胞系统包括肌肉、发电细胞、视网膜感光细胞、脑细胞、肾脏、盐腺、子宫肌层、胎盘、胰腺、胸腺、甲状腺、肠上皮细胞、内皮细胞、软骨和骨细胞、巨噬细胞、血小板以及肿瘤和癌细胞。人细胞质肌酸激酶-B，也被称为CK-B和BCK，是肌酸激酶的一种由381个氨基酸组成的脑组织特异性亚型。人细胞质肌酸激酶-M（CK-M，MCK）是肌酸激酶的一种肌肉组织特异性亚型。人细胞质肌酸激酶-Mi（Mi-CK，MtCK）是肌酸激酶的一种由416个氨基酸组成的线粒体特异性亚型。细胞溶质肌酸激酶在Ca2+泵的能量调节和维持Ca2+稳态中起着重要作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    creatine kinase-M/B 抗体 (BDI937) 参考文献:

    1. 人类精子中的肌酸激酶M亚型被鉴定为70千道尔顿的热休克蛋白HspA2。  |  Huszar, G., et al. 2000. Biol Reprod. 63: 925-32. PMID: 10952940
    2. 肌酸激酶B是宫颈癌中活性氧的靶分子。  |  Choi, H., et al. 2001. Mol Cells. 12: 412-7. PMID: 11804344
    3. 肌酸激酶B对T细胞发育和活化的调节。  |  Zhang, Y., et al. 2009. PLoS One. 4: e5000. PMID: 19337362
    4. 人类精子中肌酸激酶B型和M型同工酶合成的精子发生相关变化。  |  Huszar, G. and Vigue, L. 1990. Mol Reprod Dev. 25: 258-62. PMID: 2331374
    5. 人类肌酸激酶-B互补DNA。核苷酸序列、肺癌中的基因表达以及染色体分配到两个不同的基因座。  |  Kaye, FJ., et al. 1987. J Clin Invest. 79: 1412-20. PMID: 2883200
    6. 阿尔茨海默氏症大脑的微解剖金字塔细胞蛋白质组学揭示了肌酸激酶B型、14-3-3-γ和热休克同源71的变异。  |  Sandebring-Matton, A., et al. 2021. Front Aging Neurosci. 13: 735334. PMID: 34867272
    7. 脂肪细胞中肌酸激酶B的表观遗传抑制将内质网应激与肥胖相关的炎症联系起来。  |  Renzi, G., et al. 2025. Mol Metab. 92: 102082. PMID: 39675471
    8. 免疫抑制M亚基活性后血清中肌酸激酶B亚基活性。  |  Gerhardt, W. and Waldenström, J. 1979. Clin Chem. 25: 1274-80. PMID: 455648
    9. 肌酸激酶B和M在正常、缺血和坏死心肌中的鉴定和定位。免疫组织化学研究。  |  Siegel, RJ., et al. 1984. J Mol Cell Cardiol. 16: 95-103. PMID: 6366242
    10. 转化背阔肌中肌酸激酶-B和磷酸肌球蛋白基因表达的激活：通过聚合酶链反应评估mRNA。  |  Alam, M., et al. 1996. J Mol Cell Cardiol. 28: 1901-10. PMID: 8899549

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    产品名称产品编号规格价格数量收藏夹

    creatine kinase-M/B 抗体 (BDI937)

    sc-56895
    100 µg/ml
    		RMB2377.00

    I am doing sandwich ELISA and I would like to know which epitopes recognice this antibody as I need to find a pair of antibodies that detect different epitopes and can be used together as capture and detection! Thanks

    Asked by: Marian_Bionos
    Thank you for your question. The exact epitope has not been mapped for this antibody, so I do not have his information to give. It was raised against purified creatine kinase-M/B dimer of human origin.
    Answered by: Tech Service
    Date published: 2017-03-31

    For Western Blot, is it recommended to use denatured or non-denatured conditions with creatine kinase-M/B (BDI937): sc-56895 antibody?

    Asked by: Randy McDonald
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 4 out of 5 by from Good bands seen in WB using SHGood bands seen in WB using SH-SY5Y and HeLa whole cell lysates. -SCBT QC
    Date published: 2013-08-03
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    creatine kinase-M/B 抗体 (BDI937) is rated 4.0 out of 5 by 1.
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