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creatine kinase-M/B 抗体 (1.BB.105): sc-70881

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说明书
  • creatine kinase-M/B抗体(1.BB.105)是小鼠单克隆IgG1 (kappa轻链),规格为100 µg/ml
  • 针对creatine kinase-M/B dimer,human来源的二聚体
  • 推荐用于 human 来源的creatine kinase-M/B WB, IP 和 ELISA检测
  • 关于如何获取creatine kinase-M/B (1.BB.105): sc-70881免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成creatine kinase-M/B 抗体 (1.BB.105)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    肌酸激酶-M/B抗体(1.BB.105)是一种IgG1κ小鼠单克隆肌酸激酶-M/B抗体,可通过WB、IP和ELISA检测人源肌酸激酶-M/B。肌酸激酶-M/B抗体(1.BB.105)可作为非偶联的抗肌酸激酶-M/B抗体形式提供。肌酸激酶(CK)是一个大的同工酶家族,调节亚细胞器中ATP的水平,通过在肌酸和腺嘌呤核苷酸之间转移磷酸盐,在能量需求波动的部位提供ATP。肌酸激酶提供驱动许多细胞系统正常功能所需的磷酸水解能量,这些细胞系统包括肌肉、电细胞、视网膜感光细胞、脑细胞、肾脏、盐腺、子宫肌层、胎盘、胰腺、胸腺、甲状腺、肠上皮细胞、内皮细胞、软骨和骨细胞、巨噬细胞、血小板、肿瘤和癌症细胞。人细胞质肌酸激酶-B,也称为CK-B和BCK,是一种381个氨基酸的肌酸激酶脑组织特异性亚型。人肌浆细胞肌酸激酶-M(CK-M,MCK)是肌酸激酶的一种肌肉组织特异性亚型。人细胞质肌酸激酶-Mi(Mi-CK,MtCK)是肌酸激酶的一种416个氨基酸的线粒体特异性亚型。细胞溶质肌酸激酶在Ca2+泵的能量调节和维持Ca2+稳态中起着重要作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    creatine kinase-M/B 抗体 (1.BB.105) 参考文献:

    1. 微阵列技术的临床应用:肌酸激酶B是上皮性卵巢癌中上调的基因,有望成为血清标志物。  |  Huddleston, HG., et al. 2005. Gynecol Oncol. 96: 77-83. PMID: 15589584
    2. 肾细胞癌患者的血清肌酸激酶B亚基。  |  Takashi, M., et al. 1992. Urol Int. 48: 144-8. PMID: 1585508
    3. Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 靶向降解肌酸激酶 B。  |  Debrincat, MA., et al. 2007. J Biol Chem. 282: 4728-4737. PMID: 17148442
    4. 肌酸激酶B通过与病毒NS4A蛋白相互作用参与丙型肝炎病毒基因组的复制。  |  Hara, H., et al. 2009. J Virol. 83: 5137-47. PMID: 19264780
    5. 人类肌酸激酶 M 基因的 cDNA 克隆和 19q13 图谱绘制。  |  Nigro, JM., et al. 1987. Am J Hum Genet. 40: 115-25. PMID: 3031982
    6. 甲状腺疾病期间血清中的肌红蛋白浓度、肌酸激酶活性及肌酸激酶B亚基浓度。  |  Docherty, I., et al. 1984. Clin Chem. 30: 42-5. PMID: 6690150
    7. 肌酸激酶-MB质量浓度与肌酸激酶-B活性在血清总肌酸激酶活性轻度升高患者急性心肌梗死检测中的应用。  |  Hulting, J., et al. 1994. J Intern Med. 235: 211-6. PMID: 8120516
    8. 急性缺血性心肌细胞中肌酸激酶M定位的变化。免疫电镜研究。  |  Otsu, N., et al. 1993. Circ Res. 73: 935-42. PMID: 8403263
    9. 大鼠子宫和大脑中肌酸激酶-B信使RNA的原位杂交。  |  Bergen, HT., et al. 1993. Mol Cell Endocrinol. 92: 111-9. PMID: 8472861
    10. 慢性容量负荷过重性肥厚中肌酸激酶-B基因的选择性诱导不受ACE抑制剂治疗的影响。  |  Schultz, D., et al. 1997. J Mol Cell Cardiol. 29: 2665-73. PMID: 9344761

    订购信息

    产品名称产品编号规格价格数量收藏夹

    creatine kinase-M/B 抗体 (1.BB.105)

    sc-70881
    100 µg/ml
    RMB2377.00

    I am doing sandwich ELISA and I would like to know which epitopes recognice this antibody as I need to find a pair of antibodies that detect different epitopes and can be used together as capture and detection! Thanks

    Asked by: Marian_Bionos
    Thank you for your question. The exact epitope has not been mapped for this antibody, so I do not have this information to share. It was raised against purified creatine kinase-M/B dimer of human origin.
    Answered by: Tech Service
    Date published: 2017-03-31

    What is the total volume provided of creatine kinase-M/B (1.BB.105): sc-70881 monoclonal antibody?

    Asked by: TinTin
    Thank you for your question. creatine kinase-M/B (1.BB.105): sc-70881 is provided as 100 µg in 1 ml total volume.
    Answered by: Technical Support
    Date published: 2017-03-06
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    Rated 5 out of 5 by from Very good antibodyI used this antibody recently. It works very well and only required band shows there.
    Date published: 2017-09-12
    Rated 4 out of 5 by from Nice bands seen in WB using SHNice bands seen in WB using SH-SY5Y and HeLa whole cell lysates. -SCBT QC
    Date published: 2014-05-11
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    creatine kinase-M/B 抗体 (1.BB.105) is rated 4.5 out of 5 by 2.
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