Date published: 2025-9-8

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Cofilin 2 抗体 (D-5): sc-166958

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说明书
  • Cofilin 2 抗体 D-5 是小鼠单克隆 IgG1 κ,Cofilin 2抗体, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Cofilin 2的C-terminus附近的氨基酸133-151之间
  • Cofilin 2 抗体 (D-5) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ,检测 mouse, rat, human 和 来源的Cofilin 2, muscle isoform; 也和以下物种反应,包括: 和 canine, bovine, porcine and avian
  • 抗Cofilin 2抗体(D-5)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Cofilin 2 (D-5): sc-166958免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Cofilin 2 抗体 (D-5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cofilin 2 抗体 (D-5) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Cofilin 2 抗体(D-5)是一种 IgG1 κ 小鼠单克隆 Cofilin 2 抗体(也被称为 Cofilin 抗体或 CFL2 抗体),它能通过 WB、IP、IF、IHC(P) 和 ELISA 等方法检测小鼠、大鼠和人类来源的 Cofilin 2 蛋白。Cofilin 2 抗体(D-5)既可以以非偶联的 Cofilin 2 抗体形式存在,也可以以多种偶联形式的 Cofilin 2 抗体存在,包括琼脂糖、HRP、PE、FITC 和多种 Alexa Fluor® 偶联物。Cofilin 2,也被称为 CFL2 或 Cofilin 肌肉亚型,是一种含有 166 个氨基酸的蛋白质,定位于细胞质和细胞骨架,以及核基质,含有一个 ADF-H 结构域。Cofilin 2 存在两种可变剪接亚型,其中一种是 CFL2a,表达于心脏和骨骼肌,另一种是 CFL2b,普遍表达。Cofilin 2 可与 F- 和 G-Actin 结合,起着控制 pH 依赖的肌动蛋白聚合和解聚的作用。Cofilin 2 在 Ser 24 位点上经历翻译后磷酸化,这一事件可能阻止 Cofilin 2 的核定位。Cofilin 2 基因的缺陷是导致 7 型棒状体肌病(NEM7)的原因,这是一种随着年龄变化的先天性肌病,其特征在于肌肉纤维中的异常线状或棒状结构。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cofilin 2 抗体 (D-5) 参考文献:

  1. 肌动蛋白的新变化ADF/纤连蛋白调节肌动蛋白动力学  |  Bamburg, JR., et al. 1999. Trends Cell Biol. 9: 364-70. PMID: 10461190
  2. 正常肌肉和再生肌肉中人类肌肉型 cofilin (CFL2) 的特征。  |  Thirion, C., et al. 2001. Eur J Biochem. 268: 3473-82. PMID: 11422377
  3. 三种小鼠肌动蛋白解聚因子/纤连蛋白在进化过程中满足了细胞类型特异性的肌动蛋白动力学要求。  |  Vartiainen, MK., et al. 2002. Mol Biol Cell. 13: 183-94. PMID: 11809832
  4. ADF/cofilin 家族:肌动蛋白重塑蛋白。  |  Maciver, SK. and Hussey, PJ. 2002. Genome Biol. 3: reviews3007. PMID: 12049672
  5. LIM 激酶和 Slingshot 通过 cofilin 的磷酸化和去磷酸化控制生长锥的运动和形态。  |  Endo, M., et al. 2003. J Neurosci. 23: 2527-37. PMID: 12684437
  6. 由编码骨骼肌肌动蛋白结合蛋白 cofilin-2 的 CFL2 基因突变引起的髓样肌病伴小孔。  |  Agrawal, PB., et al. 2007. Am J Hum Genet. 80: 162-7. PMID: 17160903
  7. 人类非肌肉型cofilin(CFL1)在11q13染色体上的图谱和肌肉型cofilin(CFL2)在14号染色体上的图谱。  |  Gillett, GT., et al. 1996. Ann Hum Genet. 60: 201-11. PMID: 8800436
  8. 丝氨酸 3 的去磷酸化调节 cofilin 的核转运。  |  Nebl, G., et al. 1996. J Biol Chem. 271: 26276-80. PMID: 8824278

订购信息

产品名称产品编号规格价格数量收藏夹

Cofilin 2 抗体 (D-5)

sc-166958
200 µg/ml
RMB2377.00

Cofilin 2 (D-5): m-IgG Fc BP-HRP 套装

sc-529094
200 µg Ab; 10 µg BP
RMB2662.00

Cofilin 2 (D-5): m-IgGκ BP-HRP 套装

sc-521810
200 µg Ab, 40 µg BP
RMB2662.00

Cofilin 2 (D-5): m-IgG1 BP-HRP 套装

sc-543314
200 µg Ab; 20 µg BP
RMB2662.00

Cofilin 2 抗体 (D-5) AC

sc-166958 AC
500 µg/ml, 25% agarose
RMB3129.00

Cofilin 2 抗体 (D-5) HRP

sc-166958 HRP
200 µg/ml
RMB2377.00

Cofilin 2 抗体 (D-5) FITC

sc-166958 FITC
200 µg/ml
RMB2482.00

Cofilin 2 抗体 (D-5) PE

sc-166958 PE
200 µg/ml
RMB2580.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 488

sc-166958 AF488
200 µg/ml
RMB2685.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 546

sc-166958 AF546
200 µg/ml
RMB2685.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 594

sc-166958 AF594
200 µg/ml
RMB2685.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 647

sc-166958 AF647
200 µg/ml
RMB2685.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 680

sc-166958 AF680
200 µg/ml
RMB2685.00

Cofilin 2 抗体 (D-5) Alexa Fluor® 790

sc-166958 AF790
200 µg/ml
RMB2685.00

Cofilin 2 (D-5) 中和勝肽

sc-166958 P
100 µg/0.5 ml
RMB511.00

Hi, For the Coffilin antibody (Anti-Cofilin 2 Antibody (D-5): sc-166958), I saw it can react with mouse species, and i was wondering what the host type of this antibody? Thank you so much!

Asked by: Baixue
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-03-28

What application is the blocking peptide sc-166958 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 1 out of 5 by from Did not show up.We tried probing transfected Huh7 cells with this antibody multiple times and unfortunately it did not show up at all. Cofilin (E-8) worked great in the same samples.
Date published: 2017-12-15
Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of Cofilin 2 expression in Sol8 whole cell lysate and rat skeletal muscle tissue extract.
Date published: 2017-01-20
Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
Date published: 2015-05-19
Rated 5 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of Cofilin 2 expression in Sol8 whole cell lysate and rat skeletal muscle tissue extract. -SCBT QC
Date published: 2015-05-15
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Cofilin 2 抗体 (D-5) is rated 4.0 out of 5 by 4.
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