Date published: 2025-9-8
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CIP2A Antibody (HL1925) - Western Blotting - Image 17311
CIP2A 抗体 (HL1925): sc-80662. HeLa (A), SW480 (B) 和 COLO 320DM (C) 全细胞裂解液中 CIP2A 表达的 Western 印迹分析.
CIP2A 抗体 (HL1925): sc-80662. HeLa (A), SW480 (B) 和 COLO 320DM (C) 全细胞裂解液中 CIP2A 表达的 Western 印迹分析.

CIP2A 抗体 (HL1925): sc-80662

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说明书
  • CIP2A 抗体 HL1925 是小鼠单克隆 IgG1 κ，CIP2A抗体, 在26篇文献中引用，规格为200 µg/ml
  • 针对C-terminal CIP2A human来源
  • 推荐用于 human 来源的CIP2A WB, IP, IF 和 IHC(P)检测
  • 还可偶联琼脂糖， 用于 IP；偶联HRP，用于WB, IHC(P) 和 ELISA; 偶联FITC以及荧光素，用于IF, IHC(P) 和 FCM
  • 还可偶联Alexa Fluor® 488 和 Alexa Fluor® 647，用于IF, IHC(P) 和 FCM
  • 关于如何获取CIP2A (HL1925): sc-80662的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgGκ BP-HRP 是 CIP2A 抗体 (HL1925) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CIP2A 抗体 (HL1925) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

CIP2A 抗体（HL1925）是一种鼠单克隆 IgG1 kappa 轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测人源 CIP2A 蛋白。CIP2A (HL1925) 抗体有非结合型和多种结合型可供选择，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。蛋白磷酸酶2A（CIP2A）的癌抑制剂，也称为p90自身抗原或KIAA1524，是一种单通道膜蛋白，通过抑制蛋白磷酸酶2A（PP2A）活性在肿瘤发生中发挥重要作用。PP2A抑制至关重要，因为这种磷酸酶调节细胞生长和分裂等多种细胞过程，而PP2A功能障碍通常与癌症进展有关。CIP2A通过阻止c-Myc去磷酸化来稳定c-Myc水平，促进肿瘤形成和恶性细胞增殖。CIP2A与PP2A的催化亚基相互作用，使c-Myc活性不受控制，从而促进人类细胞转化。CIP2A的过度表达常见于多种癌症，包括结肠癌、胃癌和头颈鳞状细胞癌，这凸显了CIP2A作为癌症诊断和预后治疗靶点和生物标志物的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CIP2A 抗体 (HL1925) 参考文献:

  1. CIP2A 是结肠癌预后不良的预测因子。  |  Teng, HW., et al. 2012. J Gastrointest Surg. 16: 1037-47. PMID: 22328001
  2. CIP2A过度表达并与断裂点簇区域-Abelson白血病病毒相互作用，参与慢性粒细胞白血病的发病过程。  |  Wang, J., et al. 2014. Med Oncol. 31: 112. PMID: 25023053
  3. p90/CIP2A 介导乳腺癌细胞增殖和凋亡。  |  Liu, X., et al. 2014. Mol Biol Rep. 41: 7471-8. PMID: 25086622
  4. 肿瘤蛋白 CIP2A 通过与肿瘤抑制因子 PP2A/B56 相互作用而稳定。  |  Wang, J., et al. 2017. EMBO Rep. 18: 437-450. PMID: 28174209
  5. CIP2A在人类子宫内膜样腺癌中过度表达，并调节细胞增殖、侵袭和凋亡。  |  Yu, N., et al. 2018. Pathol Res Pract. 214: 233-239. PMID: 29274810
  6. CIP2A 导致阿尔茨海默氏症中的 Tau/APP 磷酸化、突触病变和记忆缺陷。  |  Shentu, YP., et al. 2018. Cell Rep. 24: 713-723. PMID: 30021167
  7. CIP2A 促进肾细胞癌的增殖、侵袭和对顺铂的耐药性。  |  Zhang, Y., et al. 2018. J Cancer. 9: 4029-4038. PMID: 30410608
  8. CHK1 的连续表达驱动 pSTAT3-CIP2A 循环，促进胶质母细胞瘤细胞的存活和生长。  |  Khanna, A., et al. 2020. Mol Cancer Res. 18: 709-722. PMID: 32079743
  9. Cip2A通过ERK-Runx2途径调节MG63细胞的成骨分化。  |  Son, HE. and Jang, WG. 2021. Biofactors. 47: 658-664. PMID: 34077593
  10. 对 CIP2A 过度表达和人类恶性肿瘤突变效应的综合评估确定了可能的有害变异。  |  Tarek, MM., et al. 2021. Comput Biol Med. 139: 104986. PMID: 34739970

订购信息

产品名称产品编号规格价格数量收藏夹

CIP2A 抗体 (HL1925)

sc-80662
200 µg/ml
RMB2377.00

CIP2A (HL1925): m-IgG Fc BP-HRP 套装

sc-528699
200 µg Ab; 10 µg BP
RMB2662.00

CIP2A (HL1925): m-IgGκ BP-HRP 套装

sc-521160
200 µg Ab, 40 µg BP
RMB2662.00

CIP2A 抗体 (HL1925) AC

sc-80662 AC
500 µg/ml, 25% agarose
RMB3129.00

CIP2A 抗体 (HL1925) HRP

sc-80662 HRP
200 µg/ml
RMB2377.00

CIP2A 抗体 (HL1925) FITC

sc-80662 FITC
200 µg/ml
RMB2482.00

CIP2A 抗体 (HL1925) PE

sc-80662 PE
200 µg/ml
RMB2580.00

CIP2A 抗体 (HL1925) Alexa Fluor® 488

sc-80662 AF488
200 µg/ml
RMB2685.00

CIP2A 抗体 (HL1925) Alexa Fluor® 647

sc-80662 AF647
200 µg/ml
RMB2685.00

Can you give me the epitope for the C-terminal or AA range? thanks

Asked by: basa
Thank you for your question. This antibody was raised against C-terminal CIP2A of human origin. The exact epitope has not been mapped for this CIP2A antibody, so we are unable to provide any further details.
Answered by: Tech Service
Date published: 2019-10-04

Hello, I would be interested in testing of CIP2A (HL1925): sc-80662 antibody for mouse tissue samples for WB and IHC. All the other commercial antibodies I have tested before, do not recognize mouse Cip2a protein properly.

Asked by: AnniLaine
Thank you for your question. If you have an interest in testing a free 10 µg sample of sc-80662, please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-21

Can this antibody be used with mouse samples to detect CIP2A?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 5
Date published: 2019-10-17
  • y_2025, m_8, d_30, h_9CST
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Rated 5 out of 5 by from Excellent choice for IHC and WBThe HL1925 clone is the best choice for detection of CIP2A in IHC(P)
Date published: 2017-01-05
Rated 5 out of 5 by from Great featuresGreat data from Hela, HCT116,H1299 cells were obtained with this antibody. Nice.
Date published: 2016-11-22
Rated 5 out of 5 by from Single strong band at correct mw in HeLaSingle strong band at correct mw in HeLa, SW480 and COLO 320DM whole cell lysates. -SCBT QC
Date published: 2015-06-26
Rated 5 out of 5 by from Produced exceptional immunoperoxidase cytoplasmicProduced exceptional immunoperoxidase cytoplasmic and membrane staining in formalin fixed, paraffin-embedded human kidney tissue. -SCBT QC
Date published: 2015-01-11
Rated 5 out of 5 by from WB publishable data with human SPCA1 and A549WB publishable data with human SPCA1 and A549 - SCBT Publication Review
Date published: 2013-06-19
  • y_2025, m_8, d_30, h_9
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CIP2A 抗体 (HL1925) is rated 5.0 out of 5 by 5.
  • y_2025, m_8, d_30, h_9
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