Date published: 2026-10-24

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Cdk5 Antibody (DC 17) - Western Blotting - Image 486
Cdk5 抗体 (DC 17): sc-249. HeLa (A), K-562 (B), Jurkat (C) 和 SK-BR-3 (D) 核提取物中 Cdk5 表达的 Western 印迹分析.
Cdk5 抗体 (DC 17): sc-249. HeLa (A), K-562 (B), Jurkat (C) 和 SK-BR-3 (D) 核提取物中 Cdk5 表达的 Western 印迹分析.

Cdk5 抗体 (DC 17): sc-249

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说明书
  • Cdk5抗体(DC 17)是小鼠单克隆IgG1 κ, 在108篇文献中引用，规格为200 µg/ml
  • 针对全长重组蛋白Cdk5的抗体，来源于human
  • Cdk5 抗体 (DC 17) 推荐用于WB, IP, IF 和 ELISA ，检测 mouse, rat, human 和 Drosophila来源的Cdk5
  • 抗Cdk5抗体（DC 17）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP是Cdk5 Antibody (DC 17) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Cdk5 Antibody (DC 17) 搭配使用（请参阅下面的订购信息）。
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関連項目

额外Cdk抗体，包括Cdk1, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8和Cdk9

Cdk5抗体（DC 17）是一种小鼠单克隆IgG1 kappa轻链抗体，专门用于检测细胞周期依赖性激酶5（Cdk5），也称为PSSALRE，是一种参与神经元发育和功能的关键蛋白。Cdk5单克隆抗体（DC 17）是针对全长重组人Cdk5蛋白制备的，可与小鼠、大鼠、人和果蝇的Cdk5发生反应，因此Cdk5（DC 17）抗体非常适合用于蛋白质印迹、免疫沉淀、免疫荧光和酶联免疫吸附等实验。Cdk5主要定位于神经元的细胞质中，与激活蛋白p35和p39相互作用，调节神经元迁移、突触可塑性和神经递质释放等基本过程。Cdk5的正常运作对于维持神经元的结构和连接至关重要，而Cdk5失调与包括阿尔茨海默病在内的多种神经退行性疾病有关。Cdk5通过磷酸化关键底物来调节神经元连接和可塑性所依赖的关键信号通路，因此Cdk5成为研究正常神经元生理和病理状况的重要靶标。Cdk5单克隆抗体（DC 17）有多种结合形式，包括琼脂糖、HRP、PE、FITC和几种Alexa Fluor®结合物，为研究人员提供了满足不同实验需求的多功能选择。Cdk5（DC 17）抗体能够精确检测和全面研究Cdk5，有助于加深对Cdk5在神经生物学中的作用及其在神经系统疾病中的意义的理解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk5 抗体 (DC 17) 参考文献:

  1. Cdk5：神经退行性疾病中的多功能激酶。  |  Cheung, ZH. and Ip, NY. 2012. Trends Cell Biol. 22: 169-75. PMID: 22189166
  2. Cdk5调节神经发育、功能和疾病中的多种细胞事件。  |  Kawauchi, T. 2014. Dev Growth Differ. 56: 335-48. PMID: 24844647
  3. CDK5 在肿瘤学中的应用：最新进展和未来前景。  |  Lenjisa, JL., et al. 2017. Future Med Chem. 9: 1939-1962. PMID: 29076761
  4. 细胞周期蛋白依赖性激酶5在调节肺癌生长中的机理研究。  |  Prince, GMSH., et al. 2019. Chin J Physiol. 62: 231-240. PMID: 31793458
  5. 细胞周期蛋白依赖性激酶5在神经性疼痛中的作用。  |  Gomez, K., et al. 2020. Pain. 161: 2674-2689. PMID: 32773603
  6. CDK5 在肿瘤和肿瘤微环境中的作用。  |  Do, PA. and Lee, CH. 2020. Cancers (Basel). 13: PMID: 33396266
  7. CDK5的翻译后修饰及其在癌症中的生物学作用。  |  Gao, GB., et al. 2021. Mol Biomed. 2: 22. PMID: 35006426
  8. Cdk5介导的JIP1磷酸化通过抑制Notch1调节轴突生长  |  Im, DS., et al. 2022. BMC Biol. 20: 115. PMID: 35581583
  9. Cdk5 可调节 IP3R1 介导的 Ca2+ 动态和 Ca2+ 介导的细胞增殖。  |  NavaneethaKrishnan, S., et al. 2022. Cell Mol Life Sci. 79: 495. PMID: 36001172
  10. 一种Cdk5衍生的肽抑制Cdk5/p25活性并改善神经退行性表型。  |  Pao, PC., et al. 2023. Proc Natl Acad Sci U S A. 120: e2217864120. PMID: 37043533

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk5 抗体 (DC 17)

sc-249
200 µg/ml
CNY2422.00

Cdk5 (DC 17): m-IgG Fc BP-HRP 套装

sc-551820
200 µg Ab; 10 µg BP
CNY2715.00

Cdk5 抗体 (DC 17) AC

sc-249 AC
500 µg/ml, 25% agarose
CNY3189.00

Cdk5 抗体 (DC 17) HRP

sc-249 HRP
200 µg/ml
CNY2422.00

Cdk5 抗体 (DC 17) FITC

sc-249 FITC
200 µg/ml
CNY2527.00

Cdk5 抗体 (DC 17) PE

sc-249 PE
200 µg/ml
CNY2625.00

Cdk5 抗体 (DC 17) Alexa Fluor® 488

sc-249 AF488
200 µg/ml
CNY2738.00

Cdk5 抗体 (DC 17) Alexa Fluor® 546

sc-249 AF546
200 µg/ml
CNY2738.00

Cdk5 抗体 (DC 17) Alexa Fluor® 594

sc-249 AF594
200 µg/ml
CNY2738.00

Cdk5 抗体 (DC 17) Alexa Fluor® 647

sc-249 AF647
200 µg/ml
CNY2738.00

Cdk5 抗体 (DC 17) Alexa Fluor® 680

sc-249 AF680
200 µg/ml
CNY2738.00

Cdk5 抗体 (DC 17) Alexa Fluor® 790

sc-249 AF790
200 µg/ml
CNY2738.00

Is CDK5 antibody available for IHC (P) ?? 

Asked by: suman27
Thank you for your question. Both our Cdk5 antibodies are recommended for IHC, including paraffin embedded tissue sections.
Answered by: Tech Service
Date published: 2019-10-23

Can you recommend a positive control to use with Cdk5 (DC 17): sc-249 monoclonal antibody for Western blot?

Asked by: TinTin
We recommend HeLa + PMA nuclear extract : sc-2121, HeLa nuclear extract : sc-2120, Jurkat nuclear extract : sc-2132 or K-562 + PMA nuclear extract : sc-2131 to use as positive controls as we have great Western blot data showing specific detection of Cdk5 in these cell lines.
Answered by: Technical Support 7
Date published: 2018-01-04
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Rated 5 out of 5 by fire from good antibodygood antibody, correct band size by western blotting.
Date published: 2017-11-22
Rated 5 out of 5 by Bill28 from Superb product !!Very strong antibody for western blot applications; also nice IF staining data
Date published: 2017-02-01
Rated 5 out of 5 by jerojero from Versatile and specific antibodyWorks great in drosophila samples. Very strong and clear signal in WB. Reliable and versatile antibody.
Date published: 2016-12-29
Rated 5 out of 5 by kyleecal from Works great!Our lab uses the antibody and found it works fine.
Date published: 2016-11-14
Rated 5 out of 5 by Jane from Excellent antibodyExcellent antibody, use it routinely in WB
Date published: 2015-05-06
Rated 5 out of 5 by MS from Publishable Western blot and IP data using SHPublishable Western blot and IP data using SH-SY5Y cells, SVG p12 cells , IMR32 cells, Hs 840.T cells , MRC-5 cells and RD cells -SCBT Publication Review
Date published: 2015-04-13
Rated 5 out of 5 by SH from IF: Nice nuclear and cytoplasmic stainingIF: Nice nuclear and cytoplasmic staining with HeLa. -SCBT QC
Date published: 2015-02-06
Rated 5 out of 5 by LM from Good specificity and signal strength forGood specificity and signal strength for WB in HeLa, K-562, Jurkat and SK-BR-3 nuclear extracts. -SCBT QC
Date published: 2013-06-18
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Cdk5 抗体 (DC 17) is rated 5.0 out of 5 by 8.
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