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CD39 Antibody (BU61) - Flow Cytometry - Image 14243
CD39 抗体 (BU61): sc-65262. 用 CD39 抗体 (BU61), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.
CD39 Antibody (BU61) - Flow Cytometry - Image 14243
CD39 抗体 (BU61): sc-65262. 用 CD39 抗体 (BU61), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.
CD39 Antibody (BU61) - Immunohistochemistry Immunofluorescence - Image 398564
CD39 抗体 (BU61): sc-65262. 免疫荧光显微镜图像显示 PFA 固定, 未处理 (A) 和 PHA-P + 氢化可的松处理 (B) 的人 JJhan T 细胞, 用 1:50 稀释的 α-CD39 (sc-65262) 标记, 然后用 Alexa Fluor® 647 结合的山羊抗小鼠二抗标记. 共聚焦显微镜图像放大 100 倍. 所示图像为最大强度投影. 数据由威斯康星州密尔沃基医学院 Hudson 实验室友情提供.
CD39 Antibody (BU61) - Flow Cytometry - Image 398563
CD39 抗体 (BU61): sc-65262. 未经处理 (蓝线) 或经 PHA-P + 氢化可的松处理 (红线) 的人 JJhan T 细胞的间接 FCM 分析, 在 100 µl 细胞中标记浓度为 11 µg/106 的 α-CD39 (sc-65262), 然后标记 Alexa Fluor® 647 结合物山羊抗小鼠二抗. 黑线代表无一抗对照. 数据由威斯康星州密尔沃基医学院 Hudson 实验室友情提供
CD39 抗体 (BU61): sc-65262. 用 CD39 抗体 (BU61), 然后用 PE 结合的山羊抗小鼠 IgG: sc-3738 染色的人外周血白细胞的间接 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-3877.

CD39 抗体 (BU61): sc-65262

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说明书
  • CD39 抗体 BU61 是小鼠单克隆 IgG1 κ，CD39抗体, 在3篇文献中引用，规格为100 µg/ml
  • raised against Waldenström's macroglobulinemia cell line WM-1 of human origin
  • 推荐用于 human 来源的CD39 WB, IP, IF 和 FCM检测
  • 关于如何获取CD39 (BU61): sc-65262的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成CD39 抗体 (BU61)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 CD39 抗体包括 CD39L2 和 CD39L4

CD39抗体（BU61）是一种IgG1 κ小鼠单克隆CD39抗体（也称为CD39抗体），可通过蛋白质印迹、免疫沉淀、免疫荧光和流式细胞术检测人源CD39蛋白。CD39抗体（BU61）为非偶联型抗CD39抗体。CD39，也称为胞外核苷三磷酸二磷酸水解酶1（ENP1），是一种作为细胞外核苷酸水解酶的完整膜糖蛋白。CD39通过水解ADP生成AMP并最终生成腺苷来抑制ADP诱导的血小板聚集。细胞内CD39在6个N-糖基化位点进行糖基化，并转移到膜上，以成为活性酶。选择性剪接产生三种CD39异构体，即血管型、胎盘I型和胎盘II型。胎盘I型异构体的氨基末端不同，而胎盘II型异构体在C末端缺少氨基酸300-510。CD39在血管组织（包括胎盘、肺、骨骼肌和肾脏）以及内皮细胞、平滑肌、心肌细胞、淋巴细胞（如活化的B细胞）、活化的NK细胞、巨噬细胞、树突状细胞和血小板中表达。CD39可作为抗血栓剂，用于预处理有冠状动脉闭塞和血栓性中风风险的患者。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD39 抗体 (BU61) 参考文献:

  1. 哺乳动物质膜外核苷三磷酸二磷酸水解酶1（CD39）在细胞内并不活跃。CD39 的 N-糖基化状态与表面活性和定位有关。  |  Zhong, X., et al. 2001. J Biol Chem. 276: 41518-25. PMID: 11546800
  2. 内皮细胞 CD39/ecto-ADP 酶抑制血小板募集：对闭塞性血管疾病的意义。  |  Marcus, AJ., et al. 2001. Ital Heart J. 2: 824-30. PMID: 11770867
  3. 正常胰腺和转化胰腺中 NTPDase1/CD39 的定位。  |  Kittel, A., et al. 2002. J Histochem Cytochem. 50: 549-56. PMID: 11897808
  4. 人类 CD39 的表达, 分布和生物化学。在活化相关的淋巴细胞同型黏合剂中的作用。  |  Kansas, GS., et al. 1991. J Immunol. 146: 2235-44. PMID: 1672348
  5. CD39和CD73在免疫和炎症中的作用。  |  Antonioli, L., et al. 2013. Trends Mol Med. 19: 355-67. PMID: 23601906
  6. CD39和CD103的共同表达可识别人类实体肿瘤中的肿瘤反应性CD8 T细胞。  |  Duhen, T., et al. 2018. Nat Commun. 9: 2724. PMID: 30006565
  7. CD39在T细胞中的调节和功能。  |  Timperi, E. and Barnaba, V. 2021. Int J Mol Sci. 22: PMID: 34360833
  8. CD73抑制cGAS-STING，并与CD39协同促进胰腺癌。  |  Jacoberger-Foissac, C., et al. 2023. Cancer Immunol Res. 11: 56-71. PMID: 36409930
  9. 外核苷酸酶CD39可识别肿瘤反应性CD8+ T细胞，预测人类肺癌免疫检查点阻断的疗效。  |  Chow, A., et al. 2023. Immunity. 56: 93-106.e6. PMID: 36574773
  10. CD39/CD73/A2AR通路与癌症免疫疗法。  |  Xia, C., et al. 2023. Mol Cancer. 22: 44. PMID: 36859386
  11. CD39抑制和VISTA阻断可通过靶向衰竭的CD8+ T细胞和免疫抑制性髓样细胞克服放射治疗的耐药性。  |  Zhang, Y., et al. 2023. Cell Rep Med. 4: 101151. PMID: 37567173
  12. CD39/血管 ATP 二磷酸水解酶的鉴定和表征。  |  Kaczmarek, E., et al. 1996. J Biol Chem. 271: 33116-22. PMID: 8955160

订购信息

产品名称产品编号规格价格数量收藏夹

CD39 抗体 (BU61)

sc-65262
100 µg/ml
RMB2377.00

Hi, Does the CD39 Antibody (BU61): sc-65262 inhibit the enzyme activity of CD39

Asked by: Mohan
Thank you for your question. We do not have any data, or are aware of any product citations using this antibody for a functional activity such as CD39 enzyme inhibition.
Answered by: Technical Support
Date published: 2019-08-17

Prezados, Sou estudante de PhD da UFRJ de Brasil. Pertenço ao grupo de Robson Coutinho Silva e gostaria de saber o que preciso para receber uma amostra gratuita de CD39 sc-65262. Seria de muita ajuda e avance para minha tese. Muito obrigada!! Abços

Asked by: Maria Luciana Larrouyet
Thank you for your question. For a limited time, we are offering a free 10 µg sample of this antibody. Please contact our Technical Service Department if you would like to test the antibody before placing your order. Please call us toll-free at (800) 457-3801 option 2, e-mail <[email protected]>, or use the live chat on our website. Alternatively, please contact one of our authorized distributors in Brazil to request this free sample. https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2017-12-04

What is the recommended storage condition for CD39 (BU61): sc-65262?

Asked by: cjMara
Thank you for your question. We recommend storing the antibody at 4° C.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good choice for flow cytometryThis antibody has been used for Flow Cytometric analysis of osteoarthritic infrapatellar fat pad stem cells in published research. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Ottimo funzionamentoHo utilizzato questo anticorpo per WB su macrofagi umani e ho ottenuto un buon segnale con una banda specifica
Date published: 2021-12-02
Rated 3 out of 5 by from Worked ok for IFUsed at a 1:100 dilution. Labeled JJhan T-cells. Labeling showed surface expression, as expected; however, weak signal.
Date published: 2020-01-16
Rated 3 out of 5 by from Produced acceptable indirect FCM data forProduced acceptable indirect FCM data for human peripheral blood leukocytes stained with CD39 . -SCBT QC
Date published: 2014-03-25
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CD39抗体 (BU61) is rated 4.0 out of 5 by 4.
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