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CD28 Antibody (YTH 913.12) - Western Blotting - Image 381101
CD28 (YTH913. 12): sc-59004. WEHI-231 全细胞裂解液中 CD28 表达的 Western 印迹分析.
CD28 Antibody (YTH 913.12) - Western Blotting - Image 381101
CD28 (YTH913. 12): sc-59004. WEHI-231 全细胞裂解液中 CD28 表达的 Western 印迹分析.
CD28 Antibody (YTH 913.12) - Western Blotting - Image 18043
CD28 (YTH913. 12): sc-59004. 对 Jurkat 全细胞裂解液中 CD28 的表达进行 Western 印迹分析.
CD28 (YTH913. 12): sc-59004. WEHI-231 全细胞裂解液中 CD28 表达的 Western 印迹分析.

CD28 抗体 (YTH 913.12): sc-59004

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说明书
  • CD28 抗体 YTH 913.12 是大鼠单克隆 IgG2b，提供 200 µg/ml
  • 免疫human物种的CD28
  • 推荐用于 mouse, rat 和 human 来源的CD28 WB, IP, IF 和 FCM检测
  • 目前，我们还没有完成CD28 抗体 (YTH 913.12)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    抗原占据T细胞受体后，通过抗原呈递细胞上表达的配体传递共刺激信号，触发T细胞增殖和淋巴因子产生。抗原呈递细胞上表达的B7相关细胞表面蛋白CD80（B7-1）和CD86（B7-2）与同源T细胞受体CD28和CTLA-4（细胞毒性T淋巴细胞相关蛋白-4）结合。主要的共刺激受体CD28在静息T细胞上表达，而CTLA-4在活化T细胞上作为共抑制受体表达，并以比CD28更高的亲和力与CD80和CD86结合。SLAM是T细胞上的新型受体，当被激活时，以不依赖CD28的方式增强T细胞的扩增。B7也被称为BB1，是另一种在抗原呈递细胞上表达的CD28和CTLA-4的配体或反向受体。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    CD28 抗体 (YTH 913.12) 参考文献:

    1. 未成熟免疫突触中的 CD28 信号  |  Andres, PG., et al. 2004. J Immunol. 172: 5880-6. PMID: 15128767
    2. CD28 非依赖性异体移植排斥反应的新见解。  |  Habicht, A., et al. 2007. Am J Transplant. 7: 1917-26. PMID: 17617854
    3. 适应性免疫反应中的 CD28 协同信号传递  |  Riha, P. and Rudd, CE. 2010. Self Nonself. 1: 231-240. PMID: 21487479
    4. B7-h2 是人类 CD28 的激动配体。  |  Yao, S., et al. 2011. Immunity. 34: 729-40. PMID: 21530327
    5. 提高巴塞杜氏病血清中可溶性 CD28 的水平。  |  Sun, Z., et al. 2014. Cent Eur J Immunol. 39: 216-22. PMID: 26155127
    6. 选择性阻断人类 T 细胞上的 CD28 有助于调节同种免疫反应。  |  Zaitsu, M., et al. 2017. JCI Insight. 2: PMID: 28978798
    7. 调节性 T 细胞亚群的增殖对 CD28 的依赖程度不同。  |  Wakamatsu, E., et al. 2018. Mol Immunol. 101: 92-101. PMID: 29909367
    8. SAP 与 CD28 相互作用，抑制 T 淋巴细胞中的 PD-1 信号传导。  |  Sandigursky, S., et al. 2020. Clin Immunol. 217: 108485. PMID: 32504780
    9. CD28 在年轻肺腺癌患者预后中的作用。  |  Sun, D., et al. 2020. BMC Cancer. 20: 910. PMID: 32967633
    10. IL-7 通过 JAK 信号促进 IgG4 相关疾病患者循环 CD28 细胞毒性 T 淋巴细胞的扩增  |  Xia, CS., et al. 2022. Front Immunol. 13: 922307. PMID: 35874706

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    产品名称产品编号规格价格数量收藏夹

    CD28 抗体 (YTH 913.12)

    sc-59004
    200 µg/ml
    		RMB2377.00

    Dear Santa Cruz team, Could you please send me the references of any publications where this ab has been used for ICC/IF? Thank you! Sol

    Asked by: Solangerpm
    Thank you for your question. Unfortunately at this time we are not aware of any publications citing the use of this CD28 antibody sc-59004.
    Answered by: Technical Service
    Date published: 2017-04-20

    What is the recommended starting dilution for Western blot for CD28 (YTH913.12): sc-59004 monoclonal antibody?

    Asked by: Dr Ninau Qelp
    Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-59004.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
    Answered by: Technical Support
    Date published: 2017-03-01
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