Date published: 2025-9-6

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CD13 抗体 (WM15): sc-51522

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说明书
  • CD13 抗体 WM15 是小鼠单克隆 IgG1, 在11篇文献中引用,提供 100 µg/ml
  • 针对human AML细胞
  • 推荐用于 mouse, rat 和 human 来源的CD13 IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前,我们还没有完成CD13 抗体 (WM15)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

CD13,又称氨基肽酶N,是一种II型跨膜糖蛋白,在大多数髓系来源的细胞上表达,包括单核细胞、嗜碱性粒细胞、嗜酸性粒细胞、中性粒细胞和髓系白血病。CD13也存在于某些上皮细胞、成纤维细胞和破骨细胞上。CD13作为锌结合金属蛋白酶,在消化中发挥作用,并可能在一些调节肽(如脑啡肽)的失活中发挥作用。CD13可能通过增强癌细胞的侵袭能力和转移行为而在癌细胞的侵袭中发挥作用。CD13的活性可以通过使用特定的抑制剂来灭活,这些抑制剂可以诱导CD13阳性癌细胞的凋亡。碱性成纤维细胞生长因子(bFGF)的表达通过激活髓系和上皮CD13启动子,上调人黑色素瘤细胞中CD13的表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD13 抗体 (WM15) 参考文献:

  1. CD13/氨基肽酶N和鼠巨细胞病毒感染。  |  Kasman, LM. 2005. Virology. 334: 1-9. PMID: 15749117
  2. CD13限制炎症中TLR4内吞信号转导。  |  Ghosh, M., et al. 2015. J Immunol. 194: 4466-76. PMID: 25801433
  3. 促炎性细胞因子14-3-3ε是软骨中CD13的配体。  |  Nefla, M., et al. 2015. J Cell Sci. 128: 3250-62. PMID: 26208633
  4. CD13 上的不同表位对细胞粘附起着相反的作用。  |  Garay-Canales, CA., et al. 2018. Biomed Res Int. 2018: 4093435. PMID: 29789790
  5. CD13抑制增强化疗药物的细胞毒性作用。  |  Zhang, J., et al. 2018. Front Pharmacol. 9: 1042. PMID: 30258365
  6. CD13抑制以p-ERK1/2无关的方式增强了DR4诱导的肿瘤细胞死亡。  |  Ni, J., et al. 2021. Cancer Biol Med. 18: 569-86. PMID: 33710811
  7. CD13定向形成管腔所需的顶端-基底极性轴。  |  Wang, LT., et al. 2021. Nat Commun. 12: 4697. PMID: 34349123
  8. CD13的癌症特异性糖基化会影响其在临床前癌症组织中的检测和活性。  |  Barnieh, FM., et al. 2023. iScience. 26: 108219. PMID: 37942010
  9. 一种新型的氨基肽酶N/CD13抑制剂在与蛋白质结合后,可选择性地靶向内皮细胞形式的CD13。  |  Anderluzzi, G., et al. 2024. Cell Mol Life Sci. 81: 68. PMID: 38289472
  10. 开发并评估针对整合素αvβ3和CD13的白蛋白结合剂偶联异二聚体放射性药物,用于癌症治疗。  |  Yang, B., et al. 2024. Eur J Nucl Med Mol Imaging. 51: 3334-3345. PMID: 38787395

订购信息

产品名称产品编号规格价格数量收藏夹

CD13 抗体 (WM15)

sc-51522
100 µg/ml
RMB2377.00

CD13 抗体 (WM15) FITC

sc-51522 FITC
100 tests in 2 ml
RMB2482.00

Does this work with Rat tissue or do you have another CD13 antibody that does work with rat tissue.

Asked by: jdavis
This primary antibody is recommended and warrantied for IF (immunofluorescent staining of fresh or frozen tissues or cells fixed in methanol or acetone), however we are still gathering data to show on our website. Check back for updates! A recommended alternative antibody for IHC on rat tissue that is formalin-fixed paraffin-embedded is our CD13 Antibody (3D8): sc-13536 .
Answered by: Technical Support
Date published: 2019-04-13

Can CD13 (WM15): sc-51522 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD13 (WM15): sc-51522 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Produced clear indirect FCM data for humanProduced clear indirect FCM data for human peripheral blood leukocytes stained with CD13 . -SCBT QC
Date published: 2013-06-01
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CD13 抗体 (WM15) is rated 4.0 out of 5 by 1.
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