Date published: 2025-9-6

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CD13 抗体 (H-8): sc-166105

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说明书
  • CD13抗体(H-8)是小鼠单克隆IgG2a κ, 在6篇文献中引用,规格为200 µg/ml
  • 免疫human物种的CD13的氨基酸668-967
  • CD13 抗体 (H-8) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 CD13
  • 抗CD13抗体(H-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CD13 (H-8): sc-166105免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRPm-IgGκ BP-HRP 是 CD13 抗体 (H-8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CD13 抗体 (H-8) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

CD13抗体(H-8)是一种IgG2aκ小鼠单克隆CD13抗体,通过WB、IP、IF、IHC(P)和ELISA检测人类来源的CD13。CD13抗体(H-8)可作为非偶联的抗-CD13抗体形式,以及多种偶联形式的抗-CCD13抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。CD13,或氨基肽酶N,是一种II型跨膜糖蛋白,在大多数髓细胞来源的细胞上表达,包括单核细胞、嗜碱性粒细胞、嗜酸性粒细胞、中性粒细胞和髓细胞白血病。CD13也存在于某些上皮细胞、成纤维细胞和破骨细胞上。CD13作为一种锌结合金属蛋白酶,在消化中发挥作用,并可能在一些调节肽如脑啡肽的失活中发挥作用。CD13可能通过增强癌症细胞的侵袭能力和转移行为,在其侵袭中发挥作用。可以使用引起CD13阳性癌症细胞凋亡的特异性抑制剂来灭活CD13的活性。碱性成纤维细胞生长因子(bFGF)表达通过激活髓细胞和上皮CD13启动子上调人黑色素瘤细胞中CD13的表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD13 抗体 (H-8) 参考文献:

  1. APN/CD13的抑制导致卵巢癌细胞的渐进潜力被抑制。  |  Terauchi, M., et al. 2007. BMC Cancer. 7: 140. PMID: 17655775
  2. CD13 是单核细胞/内皮细胞粘附的新介质。  |  Mina-Osorio, P., et al. 2008. J Leukoc Biol. 84: 448-59. PMID: 18495788
  3. 系统性红斑狼疮中 CD13/氨基肽酶 N mRNA 的表达和酶活性  |  Behzadi, M., et al. 2017. Acta Reumatol Port. 42: 162-167. PMID: 28375196
  4. CD13在非小细胞肺癌中的表达可能产生治疗作用。  |  Schmidt, LH., et al. 2017. PLoS One. 12: e0177146. PMID: 28604784
  5. CD13作为抗体药物偶联物的新肿瘤靶点:与偶联物MI130110的验证。  |  Domínguez, JM., et al. 2020. J Hematol Oncol. 13: 32. PMID: 32264921
  6. CD13 通过 P38/Hsp27/CREB/ATG7 通路诱导自噬以促进肝细胞癌细胞的抗药性  |  Zhao, Y., et al. 2020. J Pharmacol Exp Ther. 374: 512-520. PMID: 32571958
  7. CD13通过激活HDAC5-LSD1-NF-κB致癌信号通路,促进肝细胞癌的发生和索拉非尼耐药性的产生。  |  Hu, B., et al. 2020. Clin Transl Med. 10: e233. PMID: 33377659
  8. 新型HDAC/CD13双重抑制剂的设计、合成和生物学评估,用于癌症治疗。  |  Jia, G., et al. 2023. Eur J Med Chem. 260: 115752. PMID: 37647727
  9. ANPEP/CD13 表达作为食管腺癌淋巴血管浸润和存活的标志物。  |  Goltsov, AA., et al. 2024. Ann Thorac Surg. 118: 241-251. PMID: 37806335
  10. 他泽莫司可降低HEPG-2和乙型肝炎病毒转染的HEPG-2中的β-catenin和CD13蛋白表达,并降低细胞活力。  |  Amin, MN., et al. 2023. Clin Epigenetics. 15: 180. PMID: 37941056

订购信息

产品名称产品编号规格价格数量收藏夹

CD13 抗体 (H-8)

sc-166105
200 µg/ml
RMB2377.00

CD13 (H-8): m-IgG Fc BP-HRP 套装

sc-528907
200 µg Ab; 10 µg BP
RMB2662.00

CD13 (H-8): m-IgGκ BP-HRP 套装

sc-521509
200 µg Ab, 40 µg BP
RMB2662.00

CD13 (H-8): m-IgG2a BP-HRP 套装

sc-547205
200 µg Ab; 10 µg BP
RMB2662.00

CD13 抗体 (H-8) AC

sc-166105 AC
500 µg/ml, 25% agarose
RMB3129.00

CD13 抗体 (H-8) HRP

sc-166105 HRP
200 µg/ml
RMB2377.00

CD13 抗体 (H-8) FITC

sc-166105 FITC
200 µg/ml
RMB2482.00

CD13 抗体 (H-8) PE

sc-166105 PE
200 µg/ml
RMB2580.00

CD13 抗体 (H-8) Alexa Fluor® 488

sc-166105 AF488
200 µg/ml
RMB2685.00

CD13 抗体 (H-8) Alexa Fluor® 546

sc-166105 AF546
200 µg/ml
RMB2685.00

CD13 抗体 (H-8) Alexa Fluor® 594

sc-166105 AF594
200 µg/ml
RMB2685.00

CD13 抗体 (H-8) Alexa Fluor® 647

sc-166105 AF647
200 µg/ml
RMB2685.00

CD13 抗体 (H-8) Alexa Fluor® 680

sc-166105 AF680
200 µg/ml
RMB2685.00

CD13 抗体 (H-8) Alexa Fluor® 790

sc-166105 AF790
200 µg/ml
RMB2685.00

Can CD13 (H-8): sc-166105 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, CD13 (H-8): sc-166105 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-25
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Rated 4 out of 5 by from Good productWorked well with western blotting at 1:500 dilution.
Date published: 2017-10-10
Rated 5 out of 5 by from good featuresuse in NB4 cells ,the trips is very abvious,thank you for your free sample
Date published: 2017-09-06
Rated 4 out of 5 by from Not expected for IHC-PI could see wide stromal cell signal(like vimentin), but not the expected macrophage signal.
Date published: 2017-04-06
Rated 4 out of 5 by from Strong band seen in WB using CCDStrong band seen in WB using CCD-1064Sk whole cell lysate. -SCBT QC
Date published: 2015-05-22
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-01-11
Rated 5 out of 5 by from Excellent immunoperoxidase apical membraneExcellent immunoperoxidase apical membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human prostate tissue. -SCBT QC
Date published: 2015-01-07
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CD13 抗体 (H-8) is rated 4.3 out of 5 by 6.
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