Date published: 2025-9-6

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CaMKKα 抗体 (6): sc-136280

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说明书
  • CaMKK alpha 抗体 6 是小鼠单克隆 IgG2a, 在1篇文献中引用,提供 50 µg/0.5 ml
  • 免疫rat物种的CaMKKα的氨基酸341-504
  • 推荐用于 mouse, rat, human 和 canine 来源的CaMKKα WB, IP 和 IF检测; 不建议用于IP
  • 目前,我们还没有完成CaMKKα 抗体 (6)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Ca2+/钙调蛋白依赖性蛋白激酶(CaM激酶)构成一个结构上相关的丝氨酸/苏氨酸激酶亚家族,包括CaMKI、CaMKII和CaMKIV。CaMKII是一种普遍表达的丝氨酸/苏氨酸蛋白激酶,可被Ca2+和钙调蛋白(CaM)激活,并参与细胞周期和转录的调控。存在四种CaMKII同工酶,分别称为α、β、γ和δ,它们可能在同一组织类型中共同表达,也可能不共同表达。CaMKIV可被Ca2+和CaM刺激,但也需要CaMK的磷酸化才能完全激活。用抗CD3单克隆抗体刺激T细胞受体CD3信号复合体可导致CaMKIV活性增加10-40倍。另一种激酶CaMKK通过特异性磷酸化位于177位的调节性苏氨酸残基来激活CaMKI。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CaMKKα 抗体 (6) 参考文献:

  1. Ca2+/钙调蛋白依赖性蛋白激酶α调节骨骼肌葡萄糖摄取,不受AMP激活蛋白激酶和Akt激活的影响。  |  Witczak, CA., et al. 2007. Diabetes. 56: 1403-9. PMID: 17287469
  2. CAMKK1在调节间充质干细胞分泌物中的新作用。  |  Dong, F., et al. 2017. Stem Cells Transl Med. 6: 1759-1766. PMID: 28688176
  3. 通过电子药效团和分子筛选方法发现有效的Camkk1激酶抑制剂。  |  Prajisha, J., et al. 2022. J Biomol Struct Dyn. 40: 2740-2756. PMID: 33155526
  4. CAMKK1中的多态性rs7214723:一种与心血管疾病相关的新的遗传变异。  |  Beghi, S., et al. 2021. Biosci Rep. 41: PMID: 34165505
  5. CAMKK1基因多态性rs7214723与肺癌患者预后的关系。  |  Zhang, H., et al. 2021. Front Oncol. 11: 757484. PMID: 34868969
  6. 壳聚糖低聚糖诱导的纤维母细胞外泌体TFAP2C通过miR-132-5p/CAMKK1轴促进外周轴突再生。  |  Zhao, Y., et al. 2023. Bioact Mater. 26: 249-263. PMID: 36936807
  7. 14-3-3蛋白通过其最后两个C端螺旋结构阻断激酶活性位点,从而抑制CaMKK1。  |  Petrvalska, O., et al. 2023. Protein Sci. 32: e4805. PMID: 37817008
  8. 钙/钙调蛋白依赖性蛋白激酶1和2(CaMKK1/2)的小分子抑制剂和配体导向降解剂的鉴定。  |  Chen, Y., et al. 2023. J Med Chem. 66: 15750-15760. PMID: 38009718
  9. Ca2+/钙调蛋白依赖性蛋白激酶α在大鼠中枢神经系统的分布:免疫组织化学研究。  |  Nakamura, Y., et al. 1996. Neurosci Lett. 204: 61-4. PMID: 8929978
  10. Ca2+/钙调蛋白依赖性蛋白激酶激酶α底物特异性研究。  |  Okuno, S., et al. 1997. J Biochem. 122: 337-43. PMID: 9378711

订购信息

产品名称产品编号规格价格数量收藏夹

CaMKKα 抗体 (6)

sc-136280
50 µg/0.5 ml
RMB2377.00

I am interested to buy an anti-CAMKK1 but before I have a question. I know that this protein in human is about 55 kDa and I saw in the picture here on the website that it seems bigger (about 68). Why?

Asked by: zvofi
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

What is the recommended fixation method for immunofluorescence staining with CaMKKα (6): sc-136280 monoclonal antibody?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Good for WB in rat brain tissue extractGood for WB in rat brain tissue extract. -SCBT QC
Date published: 2014-07-18
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CaMKKα 抗体 (6) is rated 4.0 out of 5 by 1.
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