Date published: 2025-9-6

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C1q-C 抗体 (A-12): sc-365301

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说明书
  • C1q-C 抗体 A-12 是小鼠单克隆 IgG1 κ,C1q-C抗体, 在5篇文献中引用,规格为200 µg/ml
  • 免疫human物种的C1q-C的氨基酸101-155
  • C1q-C 抗体 (A-12) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 precursor and mature C1q-C
  • 抗C1q-C抗体(A-12)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取C1q-C (A-12): sc-365301免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 C1q-C 抗体 (A-12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与C1q-C 抗体 (A-12) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

C1q-C抗体(A-12)是一种IgG1κ小鼠单克隆C1q-C抗体(也称为C1q-C抗体),可通过WB、IP、IF、IHC(P)和ELISA检测人源C1q-C蛋白。 C1q-C抗体(A-12)有非偶联抗C1q-C抗体形式和多种偶联形式的抗C1q-C抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。 C1q是经典补体途径的亚组分,由9个亚基组成,介导经典补体激活,因此在免疫反应中起重要作用。 其中6个亚基是A和B链的二硫键连接的二聚体,而其中3个亚基,即C1q-A至C1q-C,是C链的二硫键连接的二聚体。 效应细胞上存在C1q受体,可以调节其活性,这可能是抗体依赖或非依赖的。 巨噬细胞是C1q的主要来源,而抗炎药物和细胞因子可以不同程度地调节mRNA和蛋白质的表达。 但是,它调节血小板与胶原蛋白和免疫复合物相互作用的能力表明C1q影响稳态以及其他免疫活动,并且可能影响免疫损伤引起的血栓并发症。 C1q-A、C1q-B和C1q-C的缺陷导致经典途径失活,导致一种罕见的遗传性疾病,其特征为狼疮样症状。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

C1q-C 抗体 (A-12) 参考文献:

  1. C1q:结构, 功能和受体。  |  Kishore, U. and Reid, KB. 2000. Immunopharmacology. 49: 159-70. PMID: 10904115
  2. C1q调节区多态性可下调小鼠c1q蛋白水平,并与狼疮肾炎有关。  |  Miura-Shimura, Y., et al. 2002. J Immunol. 169: 1334-9. PMID: 12133956
  3. 抗炎药物在体外调节人体腹腔巨噬细胞的 C1q 分泌。  |  Faust, D., et al. 2002. Biochem Pharmacol. 64: 457-62. PMID: 12147297
  4. 白细胞介素-1, 白细胞介素-6 和干扰素-γ 对常驻和受刺激的小鼠腹腔巨噬细胞中 C1q mRNA 表达和分泌的体外调节作用。  |  Faust, D. and Loos, M. 2002. Immunobiology. 206: 368-76. PMID: 12437068
  5. 成人周围神经中的补体因子:在能量代谢中的潜在作用。  |  Chrast, R., et al. 2004. Neurochem Int. 45: 353-9. PMID: 15145549
  6. 正常和患病滑膜中经典补体途径成分和调节蛋白的表达。  |  Gulati, P., et al. 1994. Rheumatol Int. 14: 13-9. PMID: 7939135
  7. 小鼠的 C1q 基因集中在第 4 号染色体上,基因组织结构保持不变。  |  Petry, F., et al. 1996. Immunogenetics. 43: 370-6. PMID: 8606057
  8. 补体成分 C1q 的血小板受体:对止血和血栓形成的影响。  |  Peerschke, EI. and Ghebrehiwet, B. 1998. Immunobiology. 199: 239-49. PMID: 9777409

订购信息

产品名称产品编号规格价格数量收藏夹

C1q-C 抗体 (A-12)

sc-365301
200 µg/ml
RMB2377.00

C1q-C (A-12): m-IgG Fc BP-HRP 套装

sc-527350
200 µg Ab; 10 µg BP
RMB2662.00

C1q-C (A-12): m-IgG1 BP-HRP 套装

sc-532723
200 µg Ab; 20 µg BP
RMB2662.00

C1q-C 抗体 (A-12) AC

sc-365301 AC
500 µg/ml, 25% agarose
RMB3129.00

C1q-C 抗体 (A-12) HRP

sc-365301 HRP
200 µg/ml
RMB2377.00

C1q-C 抗体 (A-12) FITC

sc-365301 FITC
200 µg/ml
RMB2482.00

C1q-C 抗体 (A-12) PE

sc-365301 PE
200 µg/ml
RMB2580.00

C1q-C 抗体 (A-12) Alexa Fluor® 488

sc-365301 AF488
200 µg/ml
RMB2685.00

C1q-C 抗体 (A-12) Alexa Fluor® 546

sc-365301 AF546
200 µg/ml
RMB2685.00

C1q-C 抗体 (A-12) Alexa Fluor® 594

sc-365301 AF594
200 µg/ml
RMB2685.00

C1q-C 抗体 (A-12) Alexa Fluor® 647

sc-365301 AF647
200 µg/ml
RMB2685.00

C1q-C 抗体 (A-12) Alexa Fluor® 680

sc-365301 AF680
200 µg/ml
RMB2685.00

C1q-C 抗体 (A-12) Alexa Fluor® 790

sc-365301 AF790
200 µg/ml
RMB2685.00

Have you tested this antibody with mouse samples for Western blotting? Do you still offer Positive Controls: C1q-C (h2): 293 Lysate: sc-128184 or even negative controls (C1q-C KO lysates)? Thanks!

Asked by: JerryLin
Thank you for your question. C1q-C Antibody (A-12): sc-365301 has been tested with but is not recommended for use with murine samples. We currently do not offer sc-128184.
Answered by: Tech Support Europe
Date published: 2020-08-14

Was tested whether this antibody also detects murine C1q? Best regards

Asked by: maabeln
Thank you for your question. We have not yet tested this antibody, C1q-C (A-12): sc-365301, for detection if C1q-C in mouse samples and so this species reactivity is not recommended at this time.
Answered by: Technical Support
Date published: 2017-11-02

I would like to receive a free 10 µg sample of C1q-C (A-12): sc-365301 for testing. How can that be arranged? Kind regards Ines

Asked by: InesRamos
Thank you for your question. For a limited time, we are offering a free 10 µg sample of this antibody. Please contact our Technical Service Department if you would like to test the antibody before placing your order. Please call our European Support office toll-free at 00800 4573 8000, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-10-31

I am using C1q-C (A-12): sc-365301 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: AbPolly
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2025, m_8, d_30, h_9CST
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Rated 5 out of 5 by from good antibodythis is a good antibody which can get clear and uniform band
Date published: 2017-09-04
Rated 5 out of 5 by from Performs well in WesternPerforms well in Western, good signal with human C1q-C transfected 293 whole cell lysate. -SCBT QC
Date published: 2015-05-18
Rated 5 out of 5 by from Produced excellent immunofluorescence cytoplasmicProduced excellent immunofluorescence cytoplasmic and nuclear staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-03-26
Rated 5 out of 5 by from Strong band in WB in human spleen tissue extractStrong band in WB in human spleen tissue extract. -SCBT QC
Date published: 2015-02-21
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C1q-C 抗体 (A-12) is rated 5.0 out of 5 by 4.
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