Date published: 2025-9-8

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Bmi-1 抗体 (F-9): sc-390443

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说明书
  • Bmi-1 抗体 F-9 是小鼠单克隆 IgG1 κ,Bmi-1抗体, 在27篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Bmi-1的氨基酸228-326
  • Bmi-1 抗体 (F-9) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Bmi-1
  • 抗Bmi-1抗体(F-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-390443 X, 200 µg/0.1 ml)
  • 关于如何获取Bmi-1 (F-9): sc-390443免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Bmi-1 Antibody (F-9) for WB applications. 的首选辅助检测试剂,这些试剂现与Bmi-1 Antibody (F-9) 打包提供(请参阅下面的订购信息)。

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関連項目

Bmi-1抗体(F-9)是一种IgG1 κ小鼠单克隆Bmi-1抗体(也称为BMI1抗体、PCGF4抗体或RNF51抗体),可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Bmi-1蛋白。Bmi-1抗体(F-9)既有非偶联的抗Bmi-1抗体形式,也有多种偶联形式的抗Bmi-1抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。在黑腹果蝇中,Polycomb(Pc-g)基因家族编码染色质蛋白,这些蛋白是胚胎发育过程中同源位点抑制所必需的。Mel-18和Bmi-1是果蝇Pc-g组蛋白的哺乳动物同源物,在发育过程中有相似的表达,并参与基因表达的调控、轴骨发育、造血细胞增殖和存活的控制。Mel-18通过RING-finger模序直接与DNA结合,并优先与各种基因(包括Bcl-2、c-Myc和Hox)上的并列增强子元件结合。Mel-18是c-Myc/Cdc25信号级联中的即早反应基因,具有肿瘤抑制活性,并通过阻止S期进入负调控细胞周期进程。另外,Bmi-1已被确定为一个强效的癌基因,因为它有助于转录激活涉及早期淋巴发育的基因。Bmi-1表达的病毒激活对应于其他原癌基因(包括c-Myc和Pim)的基因特异性激活增强,随后导致淋巴瘤的发生。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bmi-1 抗体 (F-9) 参考文献:

  1. bmi-1 和 mel-18 基因产物定义了一个参与细胞增殖和肿瘤发生的 DNA 结合蛋白新家族。  |  Goebl, MG. 1991. Cell. 66: 623. PMID: 1823128
  2. 哺乳动物 bmi-1 原癌基因与果蝇调控基因 Psc 和 Su(z)2 之间的序列相似性。  |  van Lohuizen, M., et al. 1991. Nature. 353: 353-5. PMID: 1922340
  3. 具有锌指结构的新型 DNA 结合蛋白在各种肿瘤细胞中的表达。  |  Tagawa, M., et al. 1990. J Biol Chem. 265: 20021-6. PMID: 2246278
  4. BMI-1 可调节 DNA 末端切除和同源重组修复。  |  Fitieh, A., et al. 2022. Cell Rep. 38: 110536. PMID: 35320715
  5. BMI-1通过不同机制促进不同亚型乳腺癌的增殖和转移。  |  Liu, JY., et al. 2023. Cancer Sci. 114: 449-462. PMID: 36285479
  6. 治疗性抑制Bmi-1可消除腺样囊性癌中的耐药性癌干细胞。  |  Sahara, S., et al. 2023. Oral Oncol. 142: 106437. PMID: 37267716
  7. Bmi-1通过RKIP促进人类视网膜母细胞瘤细胞的增殖、迁移和侵袭,并抑制细胞凋亡。  |  Li, Q., et al. 2024. Sci Rep. 14: 14544. PMID: 38914697
  8. 克隆人类 Mel-18 基因并绘制其染色体图谱,该基因编码一种具有新 'RING-finger '图案的 DNA 结合蛋白。  |  Ishida, A., et al. 1993. Gene. 129: 249-55. PMID: 8325509
  9. mel-18是一种与Polycomb活化基团相关的哺乳动物基因,编码一种具有肿瘤抑制活性的转录负调控因子。  |  Kanno, M., et al. 1995. EMBO J. 14: 5672-8. PMID: 8521824
  10. mel-18(一种与多聚核糖体群相关的脊椎动物基因)在轴骨架的前胸规格化过程中发挥作用。  |  Akasaka, T., et al. 1996. Development. 122: 1513-22. PMID: 8625838
  11. 鉴定作为哺乳动物多聚酶复合体组成成分的 Bmi1 相互作用蛋白。  |  Alkema, MJ., et al. 1997. Genes Dev. 11: 226-40. PMID: 9009205
  12. 哺乳动物的多聚核糖组基因被归类为一种由 B 细胞受体交联诱导的新型早期反应基因。  |  Hasegawa, M., et al. 1998. Mol Immunol. 35: 559-63. PMID: 9809583

订购信息

产品名称产品编号规格价格数量收藏夹

Bmi-1 抗体 (F-9)

sc-390443
200 µg/ml
RMB2377.00

Bmi-1 (F-9): m-IgG Fc BP-HRP 套装

sc-527632
200 µg Ab; 10 µg BP
RMB2662.00

Bmi-1 (F-9): m-IgG1 BP-HRP 套装

sc-533005
200 µg Ab; 20 µg BP
RMB2662.00

Bmi-1 抗体 (F-9) X

sc-390443 X
200 µg/0.1 ml
RMB2377.00

Bmi-1 抗体 (F-9) AC

sc-390443 AC
500 µg/ml, 25% agarose
RMB3129.00

Bmi-1 抗体 (F-9) HRP

sc-390443 HRP
200 µg/ml
RMB2377.00

Bmi-1 抗体 (F-9) FITC

sc-390443 FITC
200 µg/ml
RMB2482.00

Bmi-1 抗体 (F-9) PE

sc-390443 PE
200 µg/ml
RMB2580.00

Bmi-1 抗体 (F-9) Alexa Fluor® 488

sc-390443 AF488
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9) Alexa Fluor® 546

sc-390443 AF546
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9) Alexa Fluor® 594

sc-390443 AF594
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9) Alexa Fluor® 647

sc-390443 AF647
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9) Alexa Fluor® 680

sc-390443 AF680
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9) Alexa Fluor® 790

sc-390443 AF790
200 µg/ml
RMB2685.00

Bmi-1 抗体 (F-9): sc-390443可以做人肝癌组织IHC(P)吗?

Asked by: XIE YI
感谢您的提问。 Bmi-1 抗体 (F-9): sc-390443 是不推荐做石蜡包埋的切片的IHC的,冰冻组织切片的可以,请知悉。若您有其他的问题,可通过亚洲技术支持电话(+86) 021-60936350、邮箱[email protected]、或选择网页上Live Chat中的“中文支持”,联系我们的技术支持部门。 Thank you for your inquiry. Bmi-1 Antibody (F-9): sc-390443 is not recommended to be used with paraffin-embedded tissue sections in IHC, IHC with frozen tissue sections is ok. For more questions, our Asian Technical Service team is available at (+86) 021-60936350 or [email protected] or by live chat on our website.
Answered by: Technical Support 15
Date published: 2017-08-21

Can Bmi-1 (F-9): sc-390443 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Bmi-1 (F-9): sc-390443 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from ottimo funzionamentoAnticorpo molto buono! funziona bene o.n per WB su lisati di cellule tumorali
Date published: 2022-11-07
Rated 5 out of 5 by from great antibodyused this in a Western blotting experiment with an erythroblast cell line, very robust and specific signal, could be multiplexed with other antibodies in imaging system
Date published: 2022-03-02
Rated 5 out of 5 by from DOX-inducible Bmi1 expression in transgenic miceBmi-1 protein expression in the dorsal tongue epithelium of -/+ DOX Kr mice
Date published: 2021-02-04
Rated 4 out of 5 by from Good western blot signal.Used in whole cell extract to detect Bmi1 by western blot. Good and clean signal.
Date published: 2020-03-09
Rated 4 out of 5 by from Great productI get a trial package from company. I used this antibodies for WB in dilution 1:1000 in cell line. It works good.
Date published: 2018-06-10
Rated 5 out of 5 by from Works wellWe received in this antibody in the Hinck lab, and it works well. I've used the antibody for WB and IF. I also used the conjugated 594 and saw good IF results.
Date published: 2018-05-09
Rated 4 out of 5 by from Good antibodiesI used this antibodies (dilution 1:1000) in detection BMI1 in cell lines and tissue sample. It works good.
Date published: 2018-04-29
Rated 4 out of 5 by from nice bandthe antibody was tested on rat tissue sample and gave a nice band in western blot
Date published: 2017-12-13
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Bmi-1 抗体 (F-9) is rated 4.7 out of 5 by 15.
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