Date published: 2026-11-7

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Bax 抗体 (6D150): sc-70408

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说明书
  • Bax抗体(6D150)是小鼠单克隆IgG1 κ, 在31篇文献中引用,规格为200 µg/ml
  • 针对human、小鼠和大鼠Bax蛋白共有的N-terminal残基12-24的抗原性
  • 推荐用于 mouse, rat 和 human 来源的Bax WB, IP, IF 和 IHC(P)检测
  • 看 Bax (B-9): sc-7480,可查看有标记的 Bax 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Bax Antibody (6D150) for WB and IHC(P) applications. 的首选辅助检测试剂,这些试剂现与Bax Antibody (6D150) 打包提供(请参阅下面的订购信息)。
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Bax抗体(6D150)是一种小鼠单克隆IgG1抗体,可通过应用诸如蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和免疫组织化学等方法检测小鼠、大鼠和人类样本中的Bax。Bax是一种关键的促凋亡蛋白,在细胞凋亡(或程序性细胞死亡)的调节中发挥着至关重要的作用,而细胞凋亡对于维持细胞内环境平衡和消除受损或多余细胞至关重要。Bax与其抗凋亡对应物Bcl-2之间的平衡对于决定细胞命运至关重要;Bax促进细胞凋亡,而Bcl-2则抑制细胞凋亡,从而影响各种生理过程和对压力的反应。Bax主要定位于线粒体外膜,在那里Bax促进细胞色素c和其他促凋亡因子从线粒体释放到细胞质中,从而触发凋亡级联反应。Bax和Bcl-2之间的相互作用尤为重要,因为Bax可以与Bcl-2形成异二聚体,从而有效抵消其保护作用,并促进细胞死亡以响应凋亡信号。了解Bax的动态及其相互作用对于阐明细胞凋亡机制以及开发针对癌症等细胞死亡失调疾病的疗法至关重要。Anti-Bax抗体(6D150)为研究人员在各种生物学背景下研究这些关键通路提供了可靠的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

含汞:所有HRP偶联物(包括组合装)均含有硫柳汞,这是一种汞化合物。请勿丢弃在垃圾中。应按照当地、州和联邦法规,将其作为危险化学品废弃物进行处置。

下载硫柳汞安全数据表(SDS)

Bax 抗体 (6D150) 参考文献:

  1. Bax 易位到线粒体后,线粒体膜电位迅速丧失。  |  Smaili, SS., et al. 2001. Cell Death Differ. 8: 909-20. PMID: 11526446
  2. Bax 和 Bak 可独立促进线粒体释放细胞色素 C。  |  Degenhardt, K., et al. 2002. J Biol Chem. 277: 14127-34. PMID: 11836241
  3. Bax诱导的拟南芥细胞死亡是通过依赖和不依赖活性氧的过程介导的。  |  Baek, D., et al. 2004. Plant Mol Biol. 56: 15-27. PMID: 15604726
  4. Bax通过尾锚依赖性和非依赖性机制靶向线粒体。  |  Valentijn, AJ., et al. 2008. Cell Death Differ. 15: 1243-54. PMID: 18437166
  5. 利用阳离子脂质体治疗人类恶性黑色素瘤的Bax mRNA疗法  |  Okumura, K., et al. 2008. J Gene Med. 10: 910-7. PMID: 18563851
  6. Bax 可激活嗜内脂蛋白 B1 的寡聚化和脂膜囊泡化。  |  Rostovtseva, TK., et al. 2009. J Biol Chem. 284: 34390-9. PMID: 19805544
  7. 人VAMP3抑制或负向调节酵母菌中Bax诱导的细胞凋亡。  |  Akintade, DD. and Chaudhuri, B. 2021. Biomedicines. 9: PMID: 33478086
  8. 裂殖酵母中 Bax 和 Bak 诱导的细胞死亡。  |  Jürgensmeier, JM., et al. 1997. Mol Biol Cell. 8: 325-39. PMID: 9190211
  9. 小鼠胸腺中的 Bax 是一种可溶性单体蛋白,在去污剂诱导下呈现不同的构象。  |  Hsu, YT. and Youle, RJ. 1998. J Biol Chem. 273: 10777-83. PMID: 9553144
  10. bax(而非 bcl-2)影响人类胰腺癌的预后。  |  Friess, H., et al. 1998. Gut. 43: 414-21. PMID: 9863489

订购信息

产品名称产品编号规格价格数量收藏夹

Bax 抗体 (6D150)

sc-70408
200 µg/ml
CNY2422.00

Bax (6D150): m-IgG Fc BP-HRP 套装

sc-539274
200 µg Ab; 10 µg BP
CNY2715.00

Bax (6D150): m-IgG1 BP-HRP 套装

sc-541372
200 µg Ab; 20 µg BP
CNY2715.00

Can Bax (6D150): sc-70408 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Dr Ninau Qelp
Thank you for your question. Yes, Bax (6D150): sc-70408 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by kuanlab from GoodGreat antibody for WB, works in mouse RAW 264.7 cells
Date published: 2025-03-18
Rated 3 out of 5 by LauraBo from anti Bax sc-70408It is a little aspecific . I used it in western blotting on cell lysates with a dilution 1:500 and 1:250
Date published: 2017-06-07
Rated 5 out of 5 by FL from Published western blot data using primaryPublished western blot data using primary cortical neuronal cells.
Date published: 2015-08-06
Rated 4 out of 5 by LM from Good specificity and signal strength in mouseGood specificity and signal strength in mouse Bax transfected 293T and HuT 78 whole cell lysates.. -SCBT QC
Date published: 2015-05-15
Rated 5 out of 5 by HC from Published data on human T98 U87 cells usingPublished data on human T98 U87 cells using this antibody for Western blot analysis -SCBT Publication Review
Date published: 2015-03-02
Rated 5 out of 5 by ET from WB Published with this antibody using onWB Published with this antibody using on rat lung epithelial cells (LECs) -SCBT Publication Review
Date published: 2015-03-01
Rated 5 out of 5 by JM from Nice publishable data on Western blot onNice publishable data on Western blot on rat H9c2 cell lines. -SCBT Publication Review
Date published: 2015-02-11
Rated 5 out of 5 by LR from Great antibody for WBGreat antibody for WB, works in human lung cancer H441 cells. -SCBT Publication Review
Date published: 2015-02-05
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Bax抗体 (6D150) is rated 4.7 out of 5 by 9.
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