Date published: 2025-9-8

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BAFF-R 抗体 (F-3): sc-365610

5.0(3)
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说明书
  • BAFF-R抗体(F-3)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 免疫human物种的BAFF-R的氨基酸22-184
  • 推荐用于 mouse, rat 和 human 来源的BAFF-R WB, IP, IF 和 ELISA检测
  • 2a BP-HRP">m-IgG2a BP-HRP是BAFF-R Antibody (F-3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与BAFF-R Antibody (F-3) 打包提供(请参阅下面的订购信息)。

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    関連項目

    TNF细胞因子家族成员TALL-1(也被称为BAFF、zTNF4、THANK和BLYS)是一种II型膜蛋白,与其他肿瘤坏死因子(TNF)细胞因子家族成员具有相似的特性。TALL-1具有与三种受体TACI、BCMA和BAFF-R结合的能力,但与其他TNF受体不同的是,BAFF-R仅特异性地结合TALL-1配体。编码人类BAFF-R的基因位于染色体22q13.1-q13.31区域,在脾脏和淋巴结中的表达水平较高,而在外周血白细胞和胸腺中的表达水平则较低。BAFF-R的表达对于将过渡性B细胞选择进入成熟B细胞池至关重要。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    BAFF-R 抗体 (F-3) 参考文献:

    1. 属于 TNF 家族的 B 细胞激活因子(BAFF)-R 是促进循环 T 细胞和 B 细胞受 BAFF 成本刺激的主要 BAFF 受体。  |  Ng, LG., et al. 2004. J Immunol. 173: 807-17. PMID: 15240667
    2. 常见变异性免疫缺陷患者的人类 BAFF 受体 TNFRSF13C(BAFF-R)的突变分析。  |  Losi, CG., et al. 2005. J Clin Immunol. 25: 496-502. PMID: 16160919
    3. 基于人横纹肌肉瘤细胞中 BAFF 受体外域-肿瘤坏死因子相关凋亡诱导配体(TRAIL)受体-2 内域融合受体表达的新型 B 细胞活化因子(BAFF)生物测定。  |  McClements, M., et al. 2008. J Immunol Methods. 337: 63-70. PMID: 18625509
    4. 肿瘤坏死因子受体家族成员 BAFF 受体在非造血来源恶性细胞中的异常表达。  |  Kohno, T., et al. 2008. Genes Cells. 13: 1061-73. PMID: 18775026
    5. 终末期肾病对 B 淋巴细胞亚群、IL-7、BAFF 和 BAFF 受体表达的影响。  |  Pahl, MV., et al. 2010. Nephrol Dial Transplant. 25: 205-12. PMID: 19684120
    6. BAFF 受体信号传导有助于未成熟 B 细胞在强直性 BCR 信号传导后分化为过渡性 B 细胞。  |  Rowland, SL., et al. 2010. J Immunol. 185: 4570-81. PMID: 20861359
    7. 双功能 BAFF 受体适配体抑制配体诱导的增殖,并向 NHL 细胞递送 siRNA。  |  Zhou, J., et al. 2013. Nucleic Acids Res. 41: 4266-83. PMID: 23470998
    8. BAFF 受体 mAb 治疗可改善高脂血症载脂蛋白E(-/-)小鼠动脉粥样硬化的发生和发展。  |  Kyaw, T., et al. 2013. PLoS One. 8: e60430. PMID: 23560095
    9. 删除 BAFF 受体 TACI 可预防系统性红斑狼疮,但不会大量减少 B 细胞数量。  |  Figgett, WA., et al. 2015. J Autoimmun. 61: 9-16. PMID: 26027434
    10. 天然折叠重组蛋白的新型 BAFF 受体抗体能在体内消除耐药性人类 B 细胞恶性肿瘤。  |  Qin, H., et al. 2018. Clin Cancer Res. 24: 1114-1123. PMID: 29180606

    订购信息

    产品名称产品编号规格价格数量收藏夹

    BAFF-R 抗体 (F-3)

    sc-365610
    200 µg/ml
    RMB2377.00

    BAFF-R (F-3): m-IgG2a BP-HRP 套装

    sc-546045
    200 µg Ab; 10 µg BP
    RMB2662.00

    Are there any issues with using sc-365610: BAFF-R (F-3) mouse monoclonal primary antibody on mouse samples?

    Asked by: jerojero
    Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-365610 conjugates.
    Answered by: Technical Support
    Date published: 2017-03-07
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    Rated 5 out of 5 by from positive Western blot data of BAFF_RThe primary antibody was used to examined the expression of BAFF-R in splenocytes of mice. The Western blot data was excellent (even with the dilution of 1: 500).
    Date published: 2017-02-13
    Rated 5 out of 5 by from Produced positive Western Blot data of BAFFProduced positive Western Blot data of BAFF-R expression in non-transfected and human BAFF-R transfected 293 whole cell lysates. -SCBT QC
    Date published: 2015-04-02
    Rated 5 out of 5 by from Produced positive Western Blot data of BAFFProduced positive Western Blot data of BAFF-R expression in IB4, BJAB and Raji whole cell lysates. -SCBT QC
    Date published: 2014-11-16
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    BAFF-R 抗体 (F-3) is rated 5.0 out of 5 by 3.
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