Date published: 2026-11-7

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α-Actin Antibody (alpha-SM1) - Western Blotting - Image 360929
α-Actin 抗体 (α-SM1): sc-130617. A-10 (A) 和 L6 (B) 全细胞裂解液中 α-Actin 表达的 Western 印迹分析.
α-Actin 抗体 (α-SM1): sc-130617. A-10 (A) 和 L6 (B) 全细胞裂解液中 α-Actin 表达的 Western 印迹分析.

α-Actin 抗体 (alpha-SM1): sc-130617

4.4(5)
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说明书
  • α-Actin抗体(alpha-SM1)是小鼠单克隆IgG2a κ, 在69篇文献中引用，规格为200 µg/ml
  • 针对human起源的smooth muscle α-Actin的N-terminal十肽
  • 推荐用于 mouse, rat 和 human 来源的smooth muscle α-Actin WB, IP, IF, IHC(P) 和 ELISA检测; 不会与 actin from fibroblasts (β-and γ-cytoplasmic), myocardium (α-myocardial), and striated muscle (α-sarcomeric)产生交联反应
  • 另提供琼脂糖偶联抗体，可用于IP实验
  • 看 α-Actin (1A4): sc-32251，可查看有标记的 α-Actin 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2a BP-HRP">m-IgG2a BP-HRP是α-Actin Antibody (alpha-SM1) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与α-Actin Antibody (alpha-SM1) 打包提供（请参阅下面的订购信息）。
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関連項目

附加Actin抗体，包括α-Actin, β-Actin, γ-Actin, Muscle Actin和Smooth Muscle Actin

所有真核细胞都会表达肌动蛋白，这种蛋白通常占细胞总蛋白的50%。肌动蛋白丝能够形成稳定和不稳定的结构，并且是微绒毛和肌肉细胞收缩装置的关键组成部分。较低等的真核生物（如酵母）只有一个肌动蛋白基因，而较高等的真核生物则具有由一个基因家族编码的多种异构体。哺乳动物组织中至少存在六种肌动蛋白，它们分为三类。α-肌动蛋白的表达仅限于各种类型的肌肉组织，而β-肌动蛋白和γ-肌动蛋白则是其他组织中肌动蛋白丝的主要成分。小GTP酶家族的成员调节肌动蛋白细胞骨架的组织结构。其中，Rho控制肌动蛋白应力纤维和粘着斑的组装，Rac调节肌动蛋白丝在质膜上的积聚，而Cdc42则刺激丝状伪足的形成。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

含汞：所有HRP偶联物（包括组合装）均含有硫柳汞，这是一种汞化合物。请勿丢弃在垃圾中。应按照当地、州和联邦法规，将其作为危险化学品废弃物进行处置。

下载硫柳汞安全数据表（SDS）

α-Actin 抗体 (alpha-SM1) 参考文献:

  1. 正常和衰竭的人心脏中α-肌动蛋白同工型的分布：形态学、形态计量学和生物化学研究。  |  Suurmeijer, AJ., et al. 2003. J Pathol. 199: 387-97. PMID: 12579541
  2. 平滑肌α-肌动蛋白是Notch/CSL的直接靶标。  |  Noseda, M., et al. 2006. Circ Res. 98: 1468-70. PMID: 16741155
  3. 平滑肌α-肌动蛋白（ACTA2）突变导致胸主动脉瘤和夹层。  |  Guo, DC., et al. 2007. Nat Genet. 39: 1488-93. PMID: 17994018
  4. 在负荷引发的心脏肥大过程中，血管平滑肌α-肌动蛋白基因被重新激活。  |  Black, FM., et al. 1991. J Clin Invest. 88: 1581-8. PMID: 1834699
  5. α-肌动蛋白蛋白和基因转录物在胚胎小鼠肌肉中共定位。  |  Lyons, GE., et al. 1991. Development. 111: 451-4. PMID: 1893870
  6. 骨骼肌α-肌动蛋白基因（ACTA1）的突变和多态性。  |  Laing, NG., et al. 2009. Hum Mutat. 30: 1267-77. PMID: 19562689
  7. 肌球蛋白相关骨骼肌α-肌动蛋白（ACTA1）突变Asp286Gly可阻止肌球蛋白的正常强结合，引发肌肉无力。  |  Ochala, J., et al. 2012. PLoS One. 7: e45923. PMID: 23029319
  8. 经LPS处理的妊娠小鼠子宫自然杀伤细胞中的α-肌动蛋白下调和穿孔素丢失  |  Zavan, B., et al. 2015. Physiol Res. 64: 427-32. PMID: 26066976
  9. TGF-β1和WNT-11通过Rho激酶-肌动蛋白-MRTF-A信号传导合作信号驱动平滑肌中sm-α-肌动蛋白的表达  |  Kumawat, K., et al. 2016. Am J Physiol Lung Cell Mol Physiol. 311: L529-37. PMID: 27422998
  10. 一种共同因子调节骨骼和心脏α-肌动蛋白基因在肌肉中的转录。  |  Muscat, GE., et al. 1988. Mol Cell Biol. 8: 4120-33. PMID: 3185543

订购信息

产品名称产品编号规格价格数量收藏夹

α-Actin 抗体 (alpha-SM1)

sc-130617
200 µg/ml
CNY2422.00

α-Actin (alpha-SM1): m-IgG2a BP-HRP 套装

sc-546020
200 µg Ab; 10 µg BP
CNY2715.00

α-Actin 抗体 (alpha-SM1) AC

sc-130617 AC
500 µg/ml, 25% agarose
CNY3189.00

I look for ZAP-70 antibodies for flowcytometry, detector PE, reactivity human, for 100 samples, this test for academic research

Asked by: Mallasi
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Service
Date published: 2022-03-28

Can this α-Actin Antibody (alpha-SM1)：sc-130617 be used to stain α-smooth muscle actin in vascular endothelial cell？

Asked by: ny1164
Thank you for your question. We have tested this antibody in vascular endothelial cells so we can not confirm reactivity in this cell type.
Answered by: Technical Support
Date published: 2019-01-25

Can α-Actin (alpha-SM1): sc-130617 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: TinTin
Thank you for your question. Yes, α-Actin (alpha-SM1): sc-130617 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-15
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Rated 4 out of 5 by jhan from Activation of Adiponectin Receptor Regulates ProprWe used the anti-SMA antibody to determine expression of smooth muscle actin in the atortic root cross section by immunofluorescent staining, and obtained a good results. We presented the results as Figure 6D in our published paper.
Date published: 2017-08-17
Rated 5 out of 5 by Cweed from Great reactivityA great performing antibody in blotting and staining procedures. It gives off a clear and specific signal and has great reactivity. This antibody has been used to publish more than 25 times.
Date published: 2017-02-07
Rated 5 out of 5 by Xinhua_Zhang from It worked well in WBIt worked well in WB, IHC, IF.
Date published: 2015-10-13
Rated 4 out of 5 by MC from Western blot data with human aortic SMCsWestern blot data with human aortic SMCs. -SCBT QC
Date published: 2013-05-01
Rated 4 out of 5 by JT from Decent bands in Western with rat pulmonaryDecent bands in Western with rat pulmonary fibroblasts. -SCBT QC
Date published: 2010-03-26
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α-Actin抗体 (alpha-SM1) is rated 4.4 out of 5 by 5.
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