Date published: 2025-9-7

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AIP2 抗体 (G-9): sc-166240

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说明书
  • AIP2抗体(G-9)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对氨基酸1-300的抗原,在AIP2的N-terminus处映射,human来源
  • 推荐用于 human 来源的AIP2 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是AIP2 Antibody (G-9) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与AIP2 Antibody (G-9) 打包提供(请参阅下面的订购信息)。

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    関連項目

    萎缩蛋白相互作用蛋白(AIP)在多聚谷氨酸序列附近与萎缩蛋白-1结合。WW结构域由35-40个氨基酸组成,其特征是四个高度保守的芳香族残基,其中两个是色氨酸。所有五个AIP都含有多个WW结构域,可分为两个不同的类别。AIP1和AIP3(WWP3)是MAGUK样多结构域蛋白,含有鸟苷酸激酶样区域、两个WW结构域和多个PDZ结构域。AIP2(WWP2)、AIP4(itchy)和AIP5(WWP1)具有高度同源性,每个都具有四个WW结构域和一个泛素连接酶特有的HECT结构域。这些相互作用蛋白与分离的亨廷顿蛋白相互作用蛋白相似,表明负责类似疾病的两个蛋白质家族之间存在功能的共性。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    AIP2 抗体 (G-9) 参考文献:

    1. WWP2 是一种很有前途的新型肿瘤基因。  |  Zhang, R., et al. 2019. Pathol Oncol Res. 25: 443-446. PMID: 30415470
    2. E3泛素连接酶WWP2对PARP1泛素化和降解的选择性靶向调节异丙肾上腺素诱导的心脏重塑。  |  Zhang, N., et al. 2020. Cell Death Differ. 27: 2605-2619. PMID: 32139900
    3. E3 连接酶 TRIM26 和 WWP2 的竞争性结合控制着胶质母细胞瘤中的 SOX2。  |  Mahlokozera, T., et al. 2021. Nat Commun. 12: 6321. PMID: 34732716
    4. 缺氧诱导的间充质干细胞通过调节WWP2/Notch1轴抑制角膜成纤维细胞增殖  |  Yang, C., et al. 2022. Regen Med. 17: 375-388. PMID: 35545948
    5. E3泛素连接酶WWP2在心脏纤维化过程中调控促纤维化单核细胞的浸润和活性。  |  Chen, H., et al. 2022. Nat Commun. 13: 7375. PMID: 36450710
    6. lncRNA BREA2通过破坏WWP2介导的Notch1泛素化来促进转移。  |  Zhang, Z., et al. 2023. Proc Natl Acad Sci U S A. 120: e2206694120. PMID: 36795754
    7. 通过调节 DDX3X 的泛素化和降解,下调 WWP2 会加重 2 型糖尿病诱导的血管内皮损伤。  |  You, S., et al. 2023. Cardiovasc Diabetol. 22: 107. PMID: 37149668
    8. BAF155 通过抑制 WWP2- 介导的 PARP1 泛素化促进心脏肥大和纤维化。  |  Zhang, N., et al. 2023. Cell Discov. 9: 46. PMID: 37156792
    9. E3 泛素连接酶 WWP2 作为治疗人类多种疾病的一个有前景的靶点。  |  You, S., et al. 2024. Mol Aspects Med. 96: 101257. PMID: 38430667
    10. WWP2调控肾脏纤维化和坏死性肌成纤维细胞的代谢重编程  |  Chen, H., et al. 2024. J Am Soc Nephrol. 35: 696-718. PMID: 38502123

    订购信息

    产品名称产品编号规格价格数量收藏夹

    AIP2 抗体 (G-9)

    sc-166240
    200 µg/ml
    RMB2377.00

    AIP2 (G-9): m-IgG Fc BP-HRP 套装

    sc-537459
    200 µg Ab; 10 µg BP
    RMB2662.00

    AIP2 (G-9): m-IgGκ BP-HRP 套装

    sc-534733
    200 µg Ab; 40 µg BP
    RMB2662.00

    What is the recommended starting dilution for Western blot for sc-166240: AIP2 (G-9) monoclonal antibody?

    Asked by: jerojero
    The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
    Answered by: Technical Support
    Date published: 2017-03-22
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    Rated 5 out of 5 by from Satisfactory Western Blot data of AIP2 expressionSatisfactory Western Blot data of AIP2 expression in non-transfected and human AIP2 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2015-02-28
    Rated 5 out of 5 by from Produced positive Western Blot data of AIP2Produced positive Western Blot data of AIP2 expression in K-562 and Jurkat whole cell lysates. -SCBT QC
    Date published: 2013-01-21
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    AIP2抗体 (G-9) is rated 5.0 out of 5 by 2.
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