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ABCG2 Antibody (BXP-21) - Western Blotting - Image 15561
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 Antibody (BXP-21) - Western Blotting - Image 15561
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 Antibody (BXP-21) - Immunofluorescence - Image 145138
ABCG2 抗体 (BXP-21): sc-58222. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.
ABCG2 Antibody (BXP-21) - Western Blotting - Image 65897
ABCG2 抗体 (BXP-21): sc-58222. 非转染: sc-117752 (A) 和人 ABCG2 转染: sc-172393 (B) 293T 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.
ABCG2 抗体 (BXP-21): sc-58222. HL-60/MX-1 (A) 和 JAR (B) 全细胞裂解液中 ABCG2 表达的 Western 印迹分析.

ABCG2 抗体 (BXP-21): sc-58222

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寫評論提問

说明书
  • ABCG2 抗体 BXP-21 是小鼠单克隆 IgG2a, 在121篇文献中引用，提供 50 µg/0.5 ml
  • 免疫human物种的ABCG2的氨基酸271-396
  • 推荐用于 mouse, rat 和 human 来源的ABCG2 WB, IP, IF 和 IHC(P)检测; 与human MDR1, MRP1 and MRP2 gene products不交叉反应
  • 看 ABCG2 (B-1): sc-377176，可查看有标记的 ABCG2 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成ABCG2 抗体 (BXP-21)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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研究信息

関連項目

额外ABC抗体，包括ABCF1, ABCG2, ABCF2, ABCA6, ABCB9, ABCC13, ABCC11, ABCD3和ABCB5

ABCG2 抗体（BXP-21）是一种小鼠单克隆 IgG2a 抗体，可通过免疫印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学等方法检测小鼠、大鼠和人样本中的 ABCG2。抗 ABCG2 抗体 (BXP-21) 以非结合形式提供，可广泛应用于研究领域。ABCG2 所属的 ATP 结合盒（ABC）转运体家族在利用 ATP 水解产生的能量跨细胞膜转运各种分子的过程中发挥着至关重要的作用。ABCG2 也被称为胎盘特异性 ABC 转运体和乳腺癌抗性蛋白（BCRP1），其作用尤其重要，因为它参与产生对化疗药物（包括蒽环类和托泊替康）的抗药性。这种抗药性机制影响了癌症治疗中化疗的疗效。ABCG2是干细胞生物学中的关键角色，在各种干细胞群中广泛表达，并负责与干细胞特性相关的侧群（SP）表型。ABCG2 在胎盘、肝脏、肠道和干细胞中大量表达，突出了其在细胞解毒和调节干细胞分化中的保护作用。ABCG2 可进行翻译后修饰，如连接糖基化，并可在体内二聚化，从而影响功能和蛋白质相互作用。ABCG2 (BXP-21) 抗体是研究人员调查其在耐药性和干细胞生物学中作用的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ABCG2 抗体 (BXP-21) 参考文献:

  1. 通过流式细胞仪鉴定神经球细胞表型。  |  Hulspas, R. and Quesenberry, PJ. 2000. Cytometry. 40: 245-50. PMID: 10878568
  2. ABC转运体是干细胞的表型标记和功能调节器。  |  Bunting, KD. 2002. Stem Cells. 20: 11-20. PMID: 11796918
  3. 小鼠侧群干细胞的正常数量需要 Bcrp1 基因的表达，Bcrp1 基因的表达可使体内造血细胞对米托蒽醌产生相对保护作用。  |  Zhou, S., et al. 2002. Proc Natl Acad Sci U S A. 99: 12339-44. PMID: 12218177
  4. 多药耐药性与癌症：人类 ABC 转运体 ABCG2 的作用。  |  Ejendal, KF. and Hrycyna, CA. 2002. Curr Protein Pept Sci. 3: 503-11. PMID: 12369998
  5. 人类 ABCG2 多药转运体的药物转运, ATP 水解和核苷酸捕获特征。通过点突变改变底物特异性。  |  Ozvegy, C., et al. 2002. J Biol Chem. 277: 47980-90. PMID: 12374800
  6. ABCG2通过ATP依赖性转运产生对吲哚咔唑化合物的抗性。  |  Nakagawa, R., et al. 2002. Biochem Biophys Res Commun. 299: 669-75. PMID: 12459192
  7. 人类胃肠道癌细胞的特征。  |  Haraguchi, N., et al. 2006. Stem Cells. 24: 506-13. PMID: 16239320
  8. 小鼠多能造血干细胞的静止和活化亚群。  |  Spangrude, GJ. and Johnson, GR. 1990. Proc Natl Acad Sci U S A. 87: 7433-7. PMID: 1977160
  9. 丹参酮 I 是一种新型 EZH2 抑制剂，可通过上调 MMP9 和 ABCG2 限制正常和恶性造血。  |  Huang, Y., et al. 2021. Theranostics. 11: 6891-6904. PMID: 34093860
  10. ABCG2是一种抑制抗菌先天免疫的伊托酸转运蛋白，它通过减轻TFEB依赖性溶酶体生物发生来发挥作用。  |  Chen, C., et al. 2024. Cell Metab. 36: 498-510.e11. PMID: 38181789
  11. 表达ABCG2的克隆再填充内皮细胞有助于形成和维持血管。  |  Lin, Y., et al. 2024. Circulation. 150: 451-465. PMID: 38682338
  12. 染料外流研究表明，在多个物种中都存在表达低水平或检测不到水平 CD34 抗原的造血干细胞。  |  Goodell, MA., et al. 1997. Nat Med. 3: 1337-45. PMID: 9396603

订购信息

产品名称产品编号规格价格数量收藏夹

ABCG2 抗体 (BXP-21)

sc-58222
50 µg/0.5 ml
RMB2377.00

For this antibody, when we do Facs, is it intracellular?

Asked by: Iamjc819
Thank you for your question. The protein this antibody recognises is present in plasma membrane and mitochondria. The antibody's epitope region spans amino acids 271-396, which corresponds to a cytoplasmic, i.e. intracellular, domain.
Answered by: Tech Support Europe
Date published: 2022-03-29

Hi, I am looking for the concentration of the antibody sc-58222. Could you provide it please? Thank you

Asked by: Anonymous
Thank you for your question. Each vial of this antibody contains 500 µl culture supernatant containing IgG2a with < 0.1% sodium azide and 0.7% stabilizer protein. We do not provide a concentration as it is a supernatant antibody.
Answered by: Tech Service
Date published: 2020-02-19

Is this antibody cross-reactive with MDR1 or any other gene products?

Asked by: AbPolly
Thank you for your inquiry. This ABCG2 antibody is non cross-reactive with the human MDR1, MRP1 and MRP2 gene products. Please contact Technical Service for information and alignments with any other proteins.
Answered by: Technical Service
Date published: 2016-12-22
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Rated 4 out of 5 by from SIRTs inhibitors and sorafenibCambinol and EX-527 affect the expression of some ABC transporters during sorafenib treatment
Date published: 2021-02-26
Rated 5 out of 5 by from Reliable and robust productIt worked for inmunoblotting with a strong signal at a dilution 1:800 for mice and rat tissues(gut and liver). I strongly recommend the product
Date published: 2019-12-04
Rated 4 out of 5 by from Good features!I hope that this antibody is good for my ABCG2 variant expression!
Date published: 2019-05-27
Rated 5 out of 5 by from Comparative trialsWe know that ABCG2 can play a protective role by removing toxins from cells and play an important role in regulating stem cell differentiation. We use it to be widely expressed in a large number of stem cells, making it an important stem cell marker for comparative trials.
Date published: 2017-02-11
Rated 5 out of 5 by from Great monoclonal antibodyExcellent monoclonal antibody for detecting endogenous ABCG2 by Western blot and IF. Cited in over 30 publications! Highly recommended
Date published: 2016-12-19
Rated 3 out of 5 by from OK for Western blot analysisOK for Western blot analysis, suitable for immunofluorescence analysis
Date published: 2015-10-12
Rated 5 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human ABCG2 protein via Western Blot analysis. -SCBT QC
Date published: 2015-05-02
Rated 5 out of 5 by from Publishable immunostaining in paraformaldehydePublishable immunostaining in paraformaldehyde fixed rat brain tissue. -SCBT Publication Review
Date published: 2015-04-28
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ABCG2 抗体 (BXP-21) is rated 4.6 out of 5 by 14.
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