SH2D4A Activators are a class of chemical compounds that play a significant role in the regulation of intracellular signaling pathways. These activators are primarily known for their ability to modulate cellular responses by interacting with SH2D4A, a key protein involved in various cellular processes. SH2D4A, or Src homology 2 domain-containing 4A, is a cytoplasmic protein that contains SH2 (Src homology 2) domains, which are crucial for its interactions with other signaling molecules within the cell. SH2 domains are essential components in signal transduction, as they enable the binding of SH2D4A to specific phosphorylated tyrosine residues on target proteins. When SH2D4A Activators interact with SH2D4A, they initiate a cascade of events that influence cellular responses, but it's important to note that their precise mechanisms may vary depending on the specific activator compound.
These chemical compounds have garnered significant interest in the field of cellular biology due to their ability to fine-tune various cellular processes. By binding to SH2D4A, these activators can modulate the activation of downstream signaling pathways, which can ultimately affect cell growth, differentiation, and even immune responses. Researchers are actively studying the diverse range of SH2D4A Activators and their specific effects on cellular functions to gain a better understanding of how they can be leveraged for potential applications.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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L-Tyrosine | 60-18-4 | sc-473512 sc-473512A sc-473512B sc-473512C | 100 g 250 g 1 kg 5 kg | ¥575.00 ¥2358.00 ¥18469.00 ¥92118.00 | 1 | |
L-酪氨酸能与SH2D4A的SH2结构域结合,可能会增强其与含磷酸酪氨酸蛋白相互作用的能力,这可能会通过SH2D4A是关键适配分子的途径增加信号传导。 | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | ¥1828.00 ¥3565.00 ¥6307.00 ¥10030.00 ¥19100.00 | 7 | |
作为一种生物活性脂质,1-磷酸鞘磷脂可激活涉及 SH2D4A 等含 SH2 结构域蛋白的信号通路,从而可能增强其在信号转导方面的活性。 | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | ¥1726.00 ¥13809.00 ¥138080.00 | 82 | |
胰岛素受体活化会导致自身磷酸化,随后下游信号分子也会发生磷酸化。SH2D4A 可通过增加与这些磷酸化分子的相互作用而被激活,从而增强其信号作用。 | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | ¥1083.00 ¥3768.00 | 50 | |
LPA 可激活 G 蛋白偶联受体 (GPCR),从而激活涉及 SH2 结构域相互作用的下游信号级联,可能会增强 SH2D4A 的活性。 | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | ¥451.00 ¥1455.00 ¥2369.00 ¥5528.00 ¥10481.00 | 119 | |
PMA 是蛋白激酶 C (PKC) 的强效激活剂,可导致可能与 SH2D4A 的 SH2 结构域相互作用的蛋白质发生磷酸化,从而增强其活性。 | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | ¥338.00 ¥677.00 ¥1049.00 | 27 | |
H2O2 可作为一种信号分子影响各种酪氨酸激酶,可能会增加与 SH2D4A 相互作用的磷酸化蛋白池,从而增强其活性。 | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | ¥857.00 ¥2990.00 | 80 | |
异诺霉素能提高细胞内的钙含量,从而激活钙依赖性蛋白激酶,使 SH2D4A 结合的靶点磷酸化,增强其活性。 | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | ¥857.00 ¥1692.00 ¥8179.00 ¥15626.00 ¥23128.00 | 73 | |
佛司可林能增加细胞内的 cAMP,从而激活 PKA,随后使可能与 SH2D4A 相互作用的蛋白质发生磷酸化,从而增强其信号功能。 |