Date published: 2025-9-6

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Insulin (CAS 11061-68-0)

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说明书

查看产品引用文献(82)

备用名:
Recombinant Human Insulin; rh-Insulin
应用:
Insulin是在E.coli中产生的分子
CAS号码:
11061-68-0
分子量:
5807
分子式:
C257H383N65O77S6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

快捷链接

胰岛素是一种肽类激素,在新陈代谢中起着至关重要的作用,主要是通过促进细胞摄取葡萄糖。在科学研究中,胰岛素对细胞摄取葡萄糖的作用机制及其更广泛的新陈代谢效应被广泛研究。具体来说,胰岛素与细胞表面的胰岛素受体结合,引发一连串细胞内信号转导事件。这一信号途径包括激活胰岛素受体底物(IRS)和磷脂酰肌醇 3-激酶(PI3K),导致葡萄糖转运体 4 型(GLUT4)囊泡转位到细胞膜上,从而促进葡萄糖摄取。除了传统的新陈代谢作用外,胰岛素还影响细胞的生长和分化,这也是一个活跃的研究领域。研究表明,胰岛素能激活多种信号通路,包括影响基因表达和细胞周期进程的 Ras-丝裂原活化蛋白激酶(MAPK)通路。胰岛素在新陈代谢和细胞调节中的这种双重作用为研究新陈代谢和有丝分裂信号的整合提供了一个宝贵的模型。


Insulin (CAS 11061-68-0) 参考文献

  1. A new approach to characterization of insulin derived from different species using 1H-NMR coupled with multivariate analysis.  |  Ohno, A., et al. 2012. Chem Pharm Bull (Tokyo). 60: 320-4. PMID: 22382411
  2. A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel.  |  Sun, Y., et al. 2019. Anal Chim Acta. 1089: 152-164. PMID: 31627812
  3. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells.  |  Gu, L., et al. 2019. Int J Biol Sci. 15: 2815-2829. PMID: 31853220
  4. Excipient-free pulmonary insulin dry powder: Pharmacokinetic and pharmacodynamics profiles in rats.  |  Quarta, E., et al. 2020. J Control Release. 323: 412-420. PMID: 32325175
  5. Injectable Silk Fibroin-Based Hydrogel for Sustained Insulin Delivery in Diabetic Rats.  |  Maity, B., et al. 2020. ACS Appl Bio Mater. 3: 3544-3552. PMID: 35025224
  6. Special Thai Oolong Tea: Chemical Profile and In Vitro Antidiabetic Activities.  |  Rujanapun, N., et al. 2022. Front Pharmacol. 13: 797032. PMID: 35321328
  7. Comparative microelectrode array data of the functional development of hPsc-derived and rat neuronal networks.  |  Kapucu, FE., et al. 2022. Sci Data. 9: 120. PMID: 35354837
  8. An SPR-based method for Hill coefficient measurements: the case of insulin-degrading enzyme.  |  Distefano, A., et al. 2022. Anal Bioanal Chem. 414: 4793-4802. PMID: 35577931
  9. Formation of subvisible particles in commercial insulin formulations.  |  Silva-Jr, H., et al. 2022. Colloids Surf B Biointerfaces. 216: 112566. PMID: 35623256
  10. Increased disulfide peptide sequence coverage via "cleavage ON/OFF" switch during nanoelectrospray  |  Gongyu Li, et al. 2014. RSC Advances. 4.103: 59650-59654.

订购信息

产品名称产品编号规格价格数量收藏夹

Insulin, 100 mg

sc-29062
100 mg
$153.00

Insulin, 1 g

sc-29062A
1 g
$1224.00

Insulin, 10 g

sc-29062B
10 g
$12239.00