Sel-1L2 inhibitors belong to a specialized class of chemical compounds designed to selectively target and modulate the activity of the Sel-1L2 protein. The Sel-1L2 protein, a member of the Sel-1 family, plays a pivotal role in cellular processes related to protein quality control and degradation. This class of inhibitors is meticulously designed to interfere with the function of Sel-1L2, thereby influencing the intricate cellular pathways associated with protein homeostasis. By selectively inhibiting Sel-1L2, these compounds exert their effects on cellular mechanisms responsible for the recognition, sorting, and eventual disposal of misfolded or aberrant proteins within the cell.Sel-1L2 inhibitors is crafted to interact specifically with the active sites or binding pockets of the Sel-1L2 protein, disrupting its normal function. The goal is to modulate the intricate balance between protein synthesis and degradation, thereby influencing cellular proteostasis.
Researchers and developers are keenly interested in understanding the structural nuances of Sel-1L2 inhibitors to enhance their selectivity and efficacy. As these inhibitors undergo further studies, the intricate details of their interaction with Sel-1L2 at the molecular level become critical for elucidating their potential impact on cellular protein quality control pathways. The ongoing exploration of Sel-1L2 inhibitors contributes significantly to our understanding of cellular biology and opens avenues for targeted interventions in conditions associated with protein misfolding and degradation.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | ¥632.00 ¥2933.00 ¥11056.00 | 163 | |
MG-132 [Z-Leu- Leu-Leu-CHO]是一种蛋白酶体抑制剂,可能会影响ERAD途径,从而可能影响与Sel-1L2相关的蛋白质降解过程。 | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | ¥1489.00 ¥12004.00 | 115 | |
硼替佐米是一种蛋白酶体抑制剂,可通过改变ER中错误折叠蛋白的降解来影响Sel-1L2的功能。 | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | ¥1264.00 ¥2245.00 ¥3915.00 ¥7706.00 ¥15073.00 ¥64556.00 | 12 | |
Eeyarestatin I通过破坏p97/VCP的功能抑制ERAD,而p97/VCP的功能对于提取折叠错误的蛋白质至关重要,可能会影响Sel-1L2的作用。 | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | ¥1907.00 ¥3373.00 | 66 | |
Tunicamycin 可抑制 N-连接的糖基化,对 ER 造成压力,并可能影响 Sel-1L2 在蛋白质质量控制中的作用。 | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | ¥1489.00 ¥5968.00 ¥11338.00 ¥69102.00 | 25 | |
Kifunensine 是一种甘露糖苷酶抑制剂,可干扰 ER 相关糖蛋白的降解,从而可能影响 Sel-1L2 介导的途径。 | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | ¥767.00 | 2 | |
氯喹以影响溶酶体功能而闻名,可间接影响与 Sel-1L2 相关的细胞降解途径。 | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | ¥1862.00 ¥6487.00 | 60 | |
Clasto-Lactacystin β-内酯特异性地靶向蛋白酶体,可能会影响 Sel-1L2- 相关的降解过程。 | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | ¥1015.00 ¥3678.00 | 13 | |
Radicicol 与 Hsp90 结合,可能会影响其客户蛋白,包括那些参与与 Sel-1L2 有关的 ERAD 途径的蛋白。 | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | ¥745.00 ¥1726.00 | 16 | |
17-AAG 是一种 Hsp90 抑制剂,可能会影响涉及 Sel-1L2 的通路中蛋白质的加工和降解。 | ||||||
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | ¥2719.00 | ||
关那苯(Guanabenz)已被证明能调节ER应激反应,可能会影响蛋白质质量控制中与Sel-1L2相关的途径。 |