DUSP (Dual specificity protein phosphatase) 抑制因子

Dual specificity phosphatases (DUSPs) are a group of enzymes that regulate cellular processes by dephosphorylating both tyrosine and serine/threonine residues on their substrate proteins. DUSPs play a critical role in controlling the activity of mitogen-activated protein kinases (MAPKs), which are key signaling molecules involved in cell proliferation, differentiation, and stress responses. By modulating MAPK activity, DUSPs can influence various cellular responses to extracellular signals. Their activity serves as a balancing mechanism in cellular signaling, ensuring that the activation of MAPK pathways is tightly regulated.

Research efforts in targeting Dual specificity phosphatases (DUSPs) for disruption or inhibition have gained interest, especially in the context of where MAPK signaling is aberrant. The development of these inhibitors is challenging due to the need for specificity and the complex nature of DUSP interactions within cellular signaling networks. Several compounds have been identified that show inhibitory activity against specific DUSPs, offering promising leads for development.