The Cyclon protein, also known as C17orf89 in humans, is a relatively less-studied protein. It is encoded by the C17orf89 gene, located on chromosome 17.Known as a mitochondrial protein, Cyclon is involved in mitochondrial function and regulation. Mitochondria, known as the powerhouses of the cell, are responsible for producing most of the cell's supply of adenosine triphosphate (ATP), used as a source of chemical energy.The protein's name, "Cyclon," comes from "CYtochrome C OXidase Negative regulation." As this suggests, Cyclon is thought to play a role in the negative regulation of cytochrome c oxidase (COX), a key enzyme involved in the mitochondrial electron transport chain that produces ATP.
Preliminary studies suggest that Cyclon might be involved in mitochondrial respiration, specifically in the regulation of COX activity. Alterations in COX function and mitochondrial respiration have been linked to various diseases, including neurodegenerative disorders and cancer. Despite its significance, much about Cyclon's precise function and involvement in cellular processes and disease states remains to be elucidated. As such, it represents an interesting target for further research, particularly in the context of mitochondrial function and its impact on cellular energy metabolism.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | ¥733.00 ¥3599.00 ¥6487.00 ¥11259.00 | 28 | |
维甲酸能影响细胞分化和增殖,可能会影响参与细胞周期控制的基因(如 Cyclon)的表达。 | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | ¥857.00 ¥1692.00 ¥8179.00 ¥15626.00 ¥23128.00 | 73 | |
佛司可林能使细胞内的 cAMP 升高,从而激活蛋白激酶 A(PKA)并调节转录因子,诱导基因表达。 | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | ¥451.00 ¥1455.00 ¥2369.00 ¥5528.00 ¥10481.00 | 119 | |
PMA 可激活蛋白激酶 C (PKC),PKC 参与调节基因表达的各种信号通路,其中可能包括 Cyclon。 | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | ¥857.00 ¥2877.00 | 18 | |
羟基脲会导致 DNA 复制应激,从而激活检查点通路并影响细胞周期相关基因的表达。 | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | ¥338.00 ¥519.00 ¥925.00 ¥2459.00 | 19 | |
丁酸钠作为组蛋白去乙酰化酶抑制剂,可以改变染色质结构,使转录因子更容易进入基因,有可能上调 Cyclon 的表达。 | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | ¥643.00 ¥2053.00 ¥1038.00 | 21 | |
喜树碱通过抑制拓扑异构酶 I 干扰 DNA 复制,可能引发 DNA 损伤反应并影响 Cyclon 的表达。 | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | ¥361.00 ¥1918.00 ¥4344.00 | 63 | |
依托泊苷通过抑制拓扑异构酶 II 可诱导 DNA 损伤,并可能影响细胞周期调节基因的表达。 | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | ¥1907.00 ¥3373.00 | 66 | |
妥尼霉素会抑制N-连接的糖基化,诱发ER应激,从而通过未折叠蛋白反应导致基因表达发生变化。 | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | ¥1061.00 ¥3937.00 | 114 | |
Thapsigargin 可破坏钙平衡并诱导 ER 应激,这可能会影响与细胞周期控制有关的基因表达。 | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | ¥699.00 ¥2008.00 | 8 | |
β-雌二醇可通过雌激素受体信号通路调节基因表达,从而可能影响细胞周期相关基因的表达。 |