NTCP (h2): 293T Lysate: sc-373067

NTCP (h2): 293T Lysate, derived from the HEK 293T cell line, is crucial for studying the Sodium Taurocholate Co-Transporting Polypeptide (NTCP), a key protein in bile acid transport and liver function. The HEK 293T cells, an enhanced version of the original HEK 293 cells, are engineered to express the SV40 large T antigen, which significantly boosts their capacity for high-efficiency protein production, making them ideal for generating lysates rich in NTCP. Researchers use NTCP (h2): 293T Lysate to investigate the mechanisms by which NTCP mediates the uptake of bile acids from the bloodstream into hepatocytes. NTCP functions as a sodium-dependent bile acid transporter, playing a pivotal role in the enterohepatic circulation of bile acids. Studies focus on how NTCP interacts with bile acids and its regulation by various factors, employing techniques such as Western blotting, immunoprecipitation, and transport assays. By analyzing NTCP's activity and regulation, scientists can explain the fundamental processes of bile acid homeostasis and liver function. This research is crucial for understanding the molecular dynamics of bile acid transport and the role of NTCP in maintaining liver health, strictly within the context of basic scientific inquiry.