4-oxo-1,4-dihydroquinoline-2-carboxylic acid (CAS 13593-94-7)

건강 상태 :

Solid

용해도 :

Soluble in water (~0.9%) at 100° C, hot alcohol, 0.1 N NaOH (4 mg/mL), DMSO (5 mg/mL), and 1.0 M NaOH (50 mg/mL-clear, pale yellow solution). Insoluble in ether.

저장 :

Store at room temperature

녹는점 :

249-250° C

비등점 :

~358.4° C at 760 mmHg (Predicted)

밀도 :

~1.4 g/cm³ (Predicted)

굴절률 :

n²⁰_D 1.64 (Predicted)

IC50 :

Glutamate receptor ionotropic, AMPA: IC₅₀ = 101 µM (rat); Glutamate NMDA receptor: IC₅₀ = 13.8 µM (rat); GPR35: EC₅₀50 = 152 µM (human)

Ki 데이타 :

Glutamate (NMDA) receptor subunit zeta 1: K_i= 5.4 µM (rat); Vesicular glutamate transporter 3: K_i= 1.3 mM (rat)

pK 값 :

pK_a: 3.49 (Predicted), pK_b: 0.36 (Predicted)

WGK 독일 :

3

RTECS :

VB2080000

PubChem CID :

Merck 색인 :

14: 5327

MDL 번호 :

MFCD00006753

EC 번호 :

207-751-5

Beilstein 기재 :

147451

SMILES :

C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O