Date published: 2025-9-17

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Anticorps pICln (C-5): sc-393525

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Fiches techniques
  • L'Anticorps pICln (C-5) est un monoclonal de souris IgG2a κ, cité dans 4 publications, fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 159-186 au niveau d'une région interne de pICln d'origine human
  • recommandé pour la détection de pICln d'origine mouse, rat, human et par WB, IP, IF, IHC(P) et ELISA; également réactif avec d'autres espèces, dont et equine, canine, bovine, porcine and avian
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps pICln (C-5) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps pICln (C-5) (voir Informations pour la commande ci-dessous).

ACCÈS RAPIDE AUX LIENS

VOIR ÉGALEMENT...

The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps pICln (C-5)

sc-393525
200 µg/ml
RMB2377.00

pICln (C-5): m-IgG Fc BP-HRP Kit

sc-538237
200 µg Ab; 10 µg BP
RMB2662.00

pICln (C-5): m-IgGκ BP-HRP Kit

sc-535811
200 µg Ab; 40 µg BP
RMB2662.00

pICln (C-5): m-IgG2a BP-HRP Kit

sc-548243
200 µg Ab; 10 µg BP
RMB2662.00

pICln (C-5) peptide neutralisant

sc-393525 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-393525 P appropriate for?

Posée par: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Répondue par: Technical Support
Date de publication: 2017-02-24
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Rated 5 de 5 de par Produced excellent immunofluorescence nuclearProduced excellent immunofluorescence nuclear and cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date de publication: 2015-04-13
Rated 5 de 5 de par Satisfactory Western Blot data of pICln expressionSatisfactory Western Blot data of pICln expression in Hep G2, ECV304, HL-60 and HeLa whole cell lysates. -SCBT QC
Date de publication: 2014-07-01
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Anticorps pICln (C-5) est évalué 5.0 de 5 de 2.
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