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HM74, also known as PUMAG or Puma-g, is a member of the G protein coupled receptor (GPCR) superfamily. In humans, HM74 is encoded by two different genes (GPR109A and GPR109B) that produce proteins, namely HM74A and HM74 (or HM74B), which are 96% homologous. In mice and rats, only one gene encodes the HM74 protein (Gpr109a). HM74 is a G(i) protein-coupled receptor that mediates the metabolic effects of nicotinic acid. Localizing to the cell membrane, HM74 is highly expressed in adipocytes, immune cells and spleen. Like all members of the GPCR superfamily, HM74 contains seven transmembrane domains. HM74 lacks the N-linked glycosylation sites near the N-terminus that are present in other GPCR family members. Furthermore, HM74 shows a more diverged amino acid sequence homology from most family members, implying different ligand specificity.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps HM74 (A-11) | sc-373932 | 200 µg/ml | RMB2377.00 | |||
HM74 (A-11): m-IgG Fc BP-HRP Kit | sc-540408 | 200 µg Ab; 10 µg BP | RMB2662.00 | |||
HM74 (A-11): m-IgG1 BP-HRP Kit | sc-542100 | 200 µg Ab; 20 µg BP | RMB2662.00 | |||
HM74 (A-11) peptide neutralisant | sc-373932 P | 100 µg/0.5 ml | RMB511.00 |