Anticorps eIF6 (A-12): sc-390441

The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. Eukaryotic initiation factors (eIFs) are utilized in a sequence of reactions that lead to 80S ribosomal assembly and, ultimately, translation. eIF6 (eukaryotic translation initiation factor 6) is also known as CAB, B2GCN homolog, p27(BBP) or B4 integrin interactor and is a 245 amino acid protein that is localized to the cytoplasm, as well as to the nucleolus within the nucleus. The eIF6 N-terminal and C-terminal subdomains are thought to contain important nucleolar localization sequences. eIF6 may be a regulator of ribosomal function and creation. eIF6 functions to bind and translocate the 60S ribosomal subunit from the nucleus to the cytoplasm, effectively preventing the 60S subunit from associating with the 40S subunit and inhibiting formation of the 80S initiation complex. The regulation of the formation of the 80S ribosomes also regulates transcription. Once translocated to the cytoplasm, the eIF6-60S ribosomal subunit complex is subject to phosphorylation via the RACK1/PKC pathway, an event that results in the dissociation of eIF6 from the 60S subunit. Upregulation of eIF6 is strongly associated with a variety of of cancers, such as ovarian cancer, suggesting that eIF6 may be involved in carcinogenesis.

L'anticorps eIF6 préféré est l'Anticorps eIF6 (A-2): sc-390432.