The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COPS6), CSN7a (COPS7, COPS7a) or CSN7b (COPS7b) and CSN8 (COPS8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, IκBα and IRF-8, as well as the CSN-dependent phosphorylation of p53. c-Jun protects and promotes degradation by the Ubl system.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps CSN1 (D-4) | sc-365617 | 200 µg/ml | RMB2377.00 | |||
CSN1 (D-4): m-IgGκ BP-HRP Kit | sc-522294 | 200 µg Ab, 40 µg BP | RMB2662.00 |