Anticorps 52 kDa Ro/SSA (E-11): sc-48430

Ro autoantigens are of clinical significance because antibodies directed against them are found in most patients with primary Sjogren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency. Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera antibodies detect not only the main protein, but also a smaller Ro/SSA protein. The genes which encode the smaller and larger proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.

L'anticorps 52 kDa Ro/SSA préféré est l'Anticorps 52 kDa Ro/SSA (D-12): sc-25351.