PRB1-3 inhibitors are a class of chemical compounds designed to target and inhibit the function of PRB1-3, which refers to members of the PRB (Proline-Rich Protein B) family, specifically PRB1, PRB2, and PRB3. These proteins are primarily found in salivary glands, where they play key roles in the secretion and function of saliva. PRB1-3 proteins belong to the proline-rich protein family, which is involved in various biological processes such as the maintenance of oral health, lubrication, and the formation of the protective film in the oral cavity. These proteins are known to interact with other salivary components and help modulate the mineral balance in the oral cavity, contributing to tooth enamel maintenance and protection against environmental factors. Inhibition of PRB1-3 allows researchers to study the molecular mechanisms underlying these functions, providing a better understanding of how these proteins contribute to oral physiology.
In research settings, PRB1-3 inhibitors are used to investigate the regulatory roles of these proteins in oral and salivary gland function. By blocking the activity of PRB1-3 proteins, scientists can explore how these inhibitors affect processes such as saliva composition, mineral homeostasis, and the protective functions that saliva provides. This inhibition allows for the analysis of how PRB1-3 proteins contribute to the overall maintenance of the oral environment, including their potential role in interactions with other salivary proteins and enzymes. Additionally, PRB1-3 inhibitors provide insight into the downstream effects on oral health, offering valuable data on how disruptions in salivary protein function can lead to imbalances in oral hygiene and physiology. Through these studies, the use of PRB1-3 inhibitors enhances our understanding of the complex molecular systems that regulate the function of saliva and its crucial role in maintaining oral health and integrity.
产品名称 | CAS # | 产品编号 | 数量 | 价格 | 应用 | 排名 |
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Benzamidine | 618-39-3 | sc-233933 | 10 g | ¥3227.00 | 1 | |
苯甲脒是PRB1所属的蛋白酶家族成员,是丝氨酸蛋白酶(如胰蛋白酶)的竞争性抑制剂。它与PRB1的活性位点结合,阻止底物进入,从而抑制其蛋白酶活性。 | ||||||
Phenylmethylsulfonyl Fluoride | 329-98-6 | sc-3597 sc-3597A | 1 g 100 g | ¥564.00 ¥7706.00 | 92 | |
PMSF 通过磺化 PRB1 活性位点丝氨酸羟基对丝氨酸蛋白酶产生不可逆的抑制作用,而丝氨酸羟基对其蛋白水解活性至关重要。 | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | ¥1241.00 ¥4513.00 ¥18220.00 | 51 | |
Aprotinin 是一种小型蛋白质,它作为一种竞争性抑制剂,与包括 PRB1 在内的丝氨酸蛋白酶的活性位点紧密结合,抑制其酶活性。 | ||||||
Chymostatin | 9076-44-2 | sc-202541 sc-202541A sc-202541B sc-202541C sc-202541D | 5 mg 10 mg 25 mg 50 mg 100 mg | ¥1726.00 ¥2877.00 ¥10611.00 ¥13121.00 ¥25101.00 | 3 | |
Chymostatin 是糜蛋白酶样丝氨酸蛋白酶的竞争性抑制剂。它通过与 PRB1 的活性位点结合来抑制 PRB1,阻止底物裂解。 | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | ¥564.00 ¥1354.00 ¥4738.00 ¥9409.00 ¥20714.00 ¥55237.00 | 33 | |
AEBSF 是一种不可逆的丝氨酸蛋白酶抑制剂,能与 PRB1 活性位点的丝氨酸残基发生反应,从而抑制其蛋白酶活性。 | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | ¥3103.00 ¥10470.00 ¥17408.00 | 14 | |
E-64是半胱氨酸蛋白酶的强效抑制剂;然而,它可以通过与PRB1活性位点半胱氨酸(如果存在)反应,或通过修饰附近的氨基酸影响活性位点构象来抑制PRB1。 | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | ¥1128.00 | ||
甲磺酸加贝酯是一种合成蛋白酶抑制剂,它通过与活性位点丝氨酸结合来抑制丝氨酸蛋白酶(如 PRB1),从而阻止底物进入。 | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | ¥903.00 ¥3385.00 | 4 | |
甲磺酸萘莫司他是一种广谱丝氨酸蛋白酶抑制剂,能与 PRB1 结合,并通过阻断活性位点抑制其活性。 |