Date published: 2025-9-8

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NCDN 抑制因子

NCDN inhibitors belong to a fascinating chemical class that has garnered significant attention and scientific interest in recent years. These inhibitors are compounds specifically designed and synthesized to target a protein called NCDN, which plays a vital role in various cellular processes. The acronym NCDN stands for neuronal calcium-binding protein and dendritic spine maturation factor, indicating its involvement in neuronal development and synaptic plasticity. NCDN inhibitors possess a unique molecular structure that allows them to interact with the active site of the NCDN protein. By binding to this active site, the inhibitors effectively hinder the normal function of NCDN and disrupt the associated signaling pathways and molecular cascades in which NCDN is involved. This interference at the molecular level offers researchers a valuable tool for investigating the intricate mechanisms underlying cellular processes regulated by NCDN.

The discovery and characterization of NCDN inhibitors have provided scientists with a means to explore the physiological consequences of inhibiting NCDN activity. Through comprehensive studies and meticulous experiments, researchers aim to unravel the precise molecular and physiological effects induced by NCDN inhibition. These investigations help elucidate the role of NCDN in various cellular contexts and shed light on its significance in neuronal development, synaptic plasticity, and other cellular processes. The chemical class of NCDN inhibitors represents a remarkable advancement in our understanding of cellular biology. Their specific and targeted action on NCDN provides scientists with an opportunity to explore the intricate interactions between this protein and other molecular components within cells. By deciphering the underlying molecular mechanisms associated with NCDN inhibition, researchers can gain valuable insights into fundamental cellular processes and pathways. Moreover, the availability of NCDN inhibitors opens up new avenues for experimental studies in scientific research. Researchers can utilize these inhibitors to manipulate NCDN activity and observe the resulting effects on cellular function and behavior. This knowledge can contribute to a deeper understanding of the fundamental principles governing cellular processes and pave the way for further discoveries in the field of molecular biology.

関連項目

Items 1 to 10 of 14 total

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产品名称CAS #产品编号数量价格应用排名

Donepezil

120014-06-4sc-279006
10 mg
¥824.00
3
(1)

乙酰胆碱酯酶抑制剂用于治疗阿尔茨海默病,通过抑制乙酰胆碱的分解来增强神经传递。

MLN 4924

905579-51-3sc-484814
1 mg
¥3159.00
1
(0)

MLN4924 是一种强效的选择性 NAE 抑制剂,具有抗癌活性。它能阻断 NEDD8 的活化,破坏 Cullin-RING E3 连接酶的功能,从而稳定其底物蛋白,诱导癌细胞的细胞周期停滞和凋亡。

MLN7243

1450833-55-2sc-507338
5 mg
¥3836.00
(0)

TAK-243是第二代NAE抑制剂,是MLN492的改进版,具有更强的效力和选择性,有望克服MLN4924的某些局限性。

Memantine hydrochloride

41100-52-1sc-203628
50 mg
¥767.00
4
(2)

NMDA 受体拮抗剂,用于治疗阿尔茨海默氏症,调节谷氨酸信号传导,减少兴奋毒性。

(S)-Rivastigmine

123441-03-2sc-472567
500 mg
¥3385.00
(0)

乙酰胆碱酯酶抑制剂,用于治疗阿尔茨海默氏症,改善胆碱能传导。

Galanthamine

357-70-0sc-218556
10 mg
¥3610.00
(0)

乙酰胆碱酯酶抑制剂,还能调节烟碱受体,增强阿尔茨海默氏症患者的认知功能。

GSK 923295

1088965-37-0sc-490136
5 mg
¥3272.00
(0)

GSK923295是一种选择性NAE抑制剂,在多种癌症模型中表现出抗肿瘤活性。它抑制NEDD8激活酶,导致Cullin-RING E3连接酶底物的积累,并诱导细胞周期停滞和细胞凋亡。

Levodopa

59-92-7sc-205372
sc-205372A
5 g
25 g
¥598.00
¥1895.00
9
(1)

用于治疗帕金森病的多巴胺前体,可补充大脑中的多巴胺水平。

S(−)-Carbidopa

28860-95-9sc-200749
sc-200749A
25 mg
100 mg
¥1061.00
¥3046.00
5
(0)

通过阻止 L-DOPA 在脑外转化为多巴胺来增强其功效。

Riluzole

1744-22-5sc-201081
sc-201081A
sc-201081B
sc-201081C
20 mg
100 mg
1 g
25 g
¥226.00
¥2132.00
¥2358.00
¥3509.00
1
(1)

调节谷氨酸信号传导,可减缓 ALS(肌萎缩性脊髓侧索硬化症)的病情发展。