Filaggrin 抑制因子

Common Filaggrin Inhibitors include, but are not limited to Cysteamine CAS 60-23-1, Cholecalciferol CAS 67-97-0, Nicotinamide CAS 98-92-0, Sodium Butyrate CAS 156-54-7 and L-Histidine CAS 71-00-1.

Filaggrin inhibitors are compounds that belong to a chemical class designed to target filaggrin, a key protein involved in the structure and function of the skin's outermost layer, the stratum corneum. Filaggrin plays a critical role in the formation of the skin barrier by aiding in the aggregation and organization of keratin filaments, which contribute to the skin's strength and integrity. This protein is synthesized in the upper layers of the epidermis and is subsequently broken down into smaller molecules that contribute to the skin's hydration and barrier function.

Filaggrin inhibitors are of interest in the realm of skin biology and dermatology as they offer a means to study the mechanisms behind the regulation of skin barrier function. By targeting filaggrin, these inhibitors allow researchers to investigate the role of this protein in maintaining proper skin hydration, protection against environmental factors, and prevention of moisture loss. Understanding the effects of filaggrin inhibition can shed light on strategies for managing skin conditions characterized by impaired barrier function, such as certain types of eczema. The study of filaggrin inhibitors contributes to the broader understanding of skin health and the intricate molecular processes that underlie the skin's protective properties.